We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P39315 (QOR2_ECOLI)
Protein
Quinone oxidoreductase 2
Gene
qorB
Organism
Escherichia coli (strain K12)
Status
Functioni
Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
1 PublicationCatalytic activityi
Kineticsi
- KM=65.6 µM for methyl-1,4-benzoquinone (MBQ)1 Publication
- KM=18 µM for NADPH1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | NADP1 Publication | 1 | |
Binding sitei | 171 | NADP1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 6 – 11 | NADP1 Publication | 6 | |
Nucleotide bindingi | 73 – 75 | NADP1 Publication | 3 | |
Nucleotide bindingi | 138 – 143 | NADP1 Publication | 6 |
GO - Molecular functioni
- NADH dehydrogenase (quinone) activity Source: RHEA
- NADPH dehydrogenase (quinone) activity Source: RHEA
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | EcoCyc:G7868-MONOMER |
BRENDAi | 1.6.5.2, 2026 |
SABIO-RKi | P39315 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:qorB Synonyms:qor2, ytfG Ordered Locus Names:b4211, JW4169 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 139 | W → A or I: 3-fold increase in the Km for methyl-1,4-benzoquinone. 1 Publication | 1 | |
Mutagenesisi | 139 | W → F: Almost no change in the Km for methyl-1,4-benzoquinone. 1 Publication | 1 | |
Mutagenesisi | 140 | Y → A or I: Almost complete loss of catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 140 | Y → F: No change. 1 Publication | 1 | |
Mutagenesisi | 143 | N → A or L: 6-fold increase in the Km for methyl-1,4-benzoquinone. No change in affinity for NADPH. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169825 | 1 – 286 | Quinone oxidoreductase 2Add BLAST | 286 |
Proteomic databases
jPOSTi | P39315 |
PaxDbi | P39315 |
PRIDEi | P39315 |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4263443, 14 interactors |
DIPi | DIP-12935N |
IntActi | P39315, 4 interactors |
STRINGi | 511145.b4211 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P39315 |
SMRi | P39315 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P39315 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NmrA-type oxidoreductase family.Curated
Phylogenomic databases
eggNOGi | COG0702, Bacteria |
HOGENOMi | CLU_007383_10_4_6 |
InParanoidi | P39315 |
OMAi | NGWYHEN |
PhylomeDBi | P39315 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR008030, NmrA-like |
Pfami | View protein in Pfam PF05368, NmrA, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
P39315-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIAITGATGQ LGHYVIESLM KTVPASQIVA IVRNPAKAQA LAAQGITVRQ
60 70 80 90 100
ADYGDEAALT SALQGVEKLL LISSSEVGQR APQHRNVINA AKAAGVKFIA
110 120 130 140 150
YTSLLHADTS PLGLADEHIE TEKMLADSGI VYTLLRNGWY SENYLASAPA
160 170 180 190 200
ALEHGVFIGA AGDGKIASAT RADYAAAAAR VISEAGHEGK VYELAGDSAW
210 220 230 240 250
TLTQLAAELT KQSGKQVTYQ NLSEADFAAA LKSVGLPDGL ADMLADSDVG
260 270 280
ASKGGLFDDS KTLSKLIGHP TTTLAESVSH LFNVNN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97107.1 U00096 Genomic DNA Translation: AAC77168.1 AP009048 Genomic DNA Translation: BAE78212.1 |
PIRi | S56436 |
RefSeqi | NP_418632.1, NC_000913.3 WP_000560561.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77168; AAC77168; b4211 BAE78212; BAE78212; BAE78212 |
GeneIDi | 948731 |
KEGGi | ecj:JW4169 eco:b4211 |
PATRICi | fig|1411691.4.peg.2490 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97107.1 U00096 Genomic DNA Translation: AAC77168.1 AP009048 Genomic DNA Translation: BAE78212.1 |
PIRi | S56436 |
RefSeqi | NP_418632.1, NC_000913.3 WP_000560561.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZCU | X-ray | 1.80 | A | 1-286 | [»] | |
2ZCV | X-ray | 2.30 | A | 1-286 | [»] | |
AlphaFoldDBi | P39315 | |||||
SMRi | P39315 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263443, 14 interactors |
DIPi | DIP-12935N |
IntActi | P39315, 4 interactors |
STRINGi | 511145.b4211 |
Proteomic databases
jPOSTi | P39315 |
PaxDbi | P39315 |
PRIDEi | P39315 |
Protocols and materials databases
DNASUi | 948731 |
Genome annotation databases
EnsemblBacteriai | AAC77168; AAC77168; b4211 BAE78212; BAE78212; BAE78212 |
GeneIDi | 948731 |
KEGGi | ecj:JW4169 eco:b4211 |
PATRICi | fig|1411691.4.peg.2490 |
Organism-specific databases
EchoBASEi | EB2400 |
Phylogenomic databases
eggNOGi | COG0702, Bacteria |
HOGENOMi | CLU_007383_10_4_6 |
InParanoidi | P39315 |
OMAi | NGWYHEN |
PhylomeDBi | P39315 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7868-MONOMER |
BRENDAi | 1.6.5.2, 2026 |
SABIO-RKi | P39315 |
Miscellaneous databases
EvolutionaryTracei | P39315 |
PROi | PR:P39315 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR008030, NmrA-like |
Pfami | View protein in Pfam PF05368, NmrA, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QOR2_ECOLI | |
Accessioni | P39315Primary (citable) accession number: P39315 Secondary accession number(s): Q2M694 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families