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UniProtKB - P39277 (YJEH_ECOLI)

Entry version 155 (10 Feb 2021)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

L-methionine/branched-chain amino acid exporter YjeH

Gene

yjeH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the efflux of L-methionine. Can also export L-leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Efflux is inhibited by carbonyl cyanide m-chlorophenylhydrazone (CCCP).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:B4141-MONOMER
MetaCyc:B4141-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.13.1, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-methionine/branched-chain amino acid exporter YjeHCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yjeH
Ordered Locus Names:b4141, JW4101
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15PeriplasmicCuratedAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 41CytoplasmicCurated5
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 89PeriplasmicCuratedAdd BLAST27
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 113CytoplasmicCurated3
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 147PeriplasmicCuratedAdd BLAST13
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 182CytoplasmicCuratedAdd BLAST14
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 219PeriplasmicCuratedAdd BLAST16
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 257CytoplasmicCuratedAdd BLAST17
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 317PeriplasmicCuratedAdd BLAST39
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 341CytoplasmicCurated3
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 378PeriplasmicCuratedAdd BLAST16
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 418Cytoplasmic1 PublicationAdd BLAST19

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion increases the susceptibility to DL-ethionine, DL-norleucine and DL-norvaline. Deletion also results in intracellular accumulation and a reduced rate of export of methionine in the presence of extracellular Met-Met dipeptides.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24T → Y: Strong decrease in methionine efflux. 1 Publication1
Mutagenesisi25G → F: Strong decrease in methionine efflux. 1 Publication1
Mutagenesisi195W → A: Strong decrease in methionine efflux. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001697381 – 418L-methionine/branched-chain amino acid exporter YjeHAdd BLAST418

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39277

PRoteomics IDEntifications database

More...PRIDEi		P39277

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in the presence of intracellular L-methionine, L-leucine or L-isoleucine.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262197, 12 interactors
852948, 1 interactor

Database of interacting proteins

More...DIPi		DIP-12573N

Protein interaction database and analysis system

More...IntActi		P39277, 4 interactors

STRING: functional protein association networks

More...STRINGi		511145.b4141

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid efflux (AAE) (TC 2.A.3.13) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0531, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_18_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39277

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39277

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002293, AA/rel_permease1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13520, AA_permease_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39277-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLKQELGL AQGIGLLSTS LLGTGVFAVP ALAALVAGNN SLWAWPVLII 
        60         70         80         90        100
LVFPIAIVFA ILGRHYPSAG GVAHFVGMAF GSRLERVTGW LFLSVIPVGL 
       110        120        130        140        150
PAALQIAAGF GQAMFGWHSW QLLLAELGTL ALVWYIGTRG ASSSANLQTV 
       160        170        180        190        200
IAGLIVALIV AIWWAGDIKP ANIPFPAPGN IELTGLFAAL SVMFWCFVGL 
       210        220        230        240        250
EAFAHLASEF KNPERDFPRA LMIGLLLAGL VYWGCTVVVL HFDAYGEKMA 
       260        270        280        290        300
AAASLPKIVV QLFGVGALWI ACVIGYLACF ASLNIYIQSF ARLVWSQAQH 
       310        320        330        340        350
NPDHYLARLS SRHIPNNALN AVLGCCVVST LVIHALEINL DALIIYANGI 
       360        370        380        390        400
FIMIYLLCML AGCKLLQGRY RLLAVVGGLL CVLLLAMVGW KSLYALIMLA 
       410 
GLWLLLPKRK TPENGITT
Length:418
Mass (Da):44,778
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9244E8281BC54AC3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97040.1
U00096 Genomic DNA Translation: AAC77101.1
AP009048 Genomic DNA Translation: BAE78143.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56369

NCBI Reference Sequences

More...RefSeqi		NP_418565.1, NC_000913.3
WP_000015837.1, NZ_STEB01000014.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77101; AAC77101; b4141
BAE78143; BAE78143; BAE78143

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57730035
948656

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4101
eco:b4141

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2559

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97040.1
U00096 Genomic DNA Translation: AAC77101.1
AP009048 Genomic DNA Translation: BAE78143.1
PIRiS56369
RefSeqiNP_418565.1, NC_000913.3
WP_000015837.1, NZ_STEB01000014.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262197, 12 interactors
852948, 1 interactor
DIPiDIP-12573N
IntActiP39277, 4 interactors
STRINGi511145.b4141

Protein family/group databases

TCDBi2.A.3.13.1, the amino acid-polyamine-organocation (apc) family

Proteomic databases

PaxDbiP39277
PRIDEiP39277

Genome annotation databases

EnsemblBacteriaiAAC77101; AAC77101; b4141
BAE78143; BAE78143; BAE78143
GeneIDi57730035
948656
KEGGiecj:JW4101
eco:b4141
PATRICifig|1411691.4.peg.2559

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2363

Phylogenomic databases

eggNOGiCOG0531, Bacteria
HOGENOMiCLU_007946_18_0_6
InParanoidiP39277
PhylomeDBiP39277

Enzyme and pathway databases

BioCyciEcoCyc:B4141-MONOMER
MetaCyc:B4141-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P39277

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYJEH_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39277
Secondary accession number(s): Q2M6G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 10, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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