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UniProtKB - P39276 (DTPC_ECOLI)

Entry version 153 (07 Apr 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Dipeptide and tripeptide permease C

Gene

dtpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine.4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.07 mM for Ala-Lys1 Publication
  2. KM=0.51 mM for Lys-Ala1 Publication

    pH dependencei

    Optimum pH is around 6.5.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processPeptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		EcoCyc:YJDL-MONOMER
    MetaCyc:YJDL-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.6.3.43, 2026

    Protein family/group databases

    Transport Classification Database

    More...    TCDBi    		2.A.17.1.5, the proton-dependent oligopeptide transporter (pot/ptr) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dipeptide and tripeptide permease CCurated
    Alternative name(s):
    Dipeptide/tripeptide:H(+) symporter DtpCCurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:dtpC1 Publication
    Synonyms:yjdL
    Ordered Locus Names:b4130, JW4091
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
    Topological domaini34 – 46PeriplasmicSequence analysisAdd BLAST13
    Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
    Topological domaini68 – 70CytoplasmicSequence analysis3
    Transmembranei71 – 93HelicalSequence analysisAdd BLAST23
    Topological domaini94 – 102PeriplasmicSequence analysis9
    Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
    Topological domaini126 – 140CytoplasmicSequence analysisAdd BLAST15
    Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
    Topological domaini162 – 164PeriplasmicSequence analysis3
    Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
    Topological domaini186 – 208CytoplasmicSequence analysisAdd BLAST23
    Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
    Topological domaini230 – 234PeriplasmicSequence analysis5
    Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
    Topological domaini256 – 262CytoplasmicSequence analysis7
    Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
    Topological domaini284 – 307PeriplasmicSequence analysisAdd BLAST24
    Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
    Topological domaini329 – 340CytoplasmicSequence analysisAdd BLAST12
    Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
    Topological domaini362 – 375PeriplasmicSequence analysisAdd BLAST14
    Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
    Topological domaini397 – 406CytoplasmicSequence analysis10
    Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
    Topological domaini428 – 446PeriplasmicSequence analysisAdd BLAST19
    Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
    Topological domaini468 – 485Cytoplasmic1 PublicationAdd BLAST18

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20E → A: Lack of activity. 1 Publication1
    Mutagenesisi20E → D: Decrease in activity. 1 Publication1
    Mutagenesisi20E → Q: Decrease in activity. Abolishes the pH dependency. 1 Publication1
    Mutagenesisi388E → A: Lack of activity. 1 Publication1
    Mutagenesisi388E → D: Decrease in activity. 1 Publication1
    Mutagenesisi388E → Q: Decrease in activity. Does not bind Ala-Lys dipeptide. 2 Publications1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643301 – 485Dipeptide and tripeptide permease CAdd BLAST485

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P39276

    PRoteomics IDEntifications database

    More...    PRIDEi    		P39276

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		4261129, 143 interactors

    STRING: functional protein association networks

    More...    STRINGi    		511145.b4130

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		COG3104, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_004790_0_0_6

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P39276

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P39276

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd17346, MFS_DtpA_like, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR005279, Dipep/tripep_permease
    IPR020846, MFS_dom
    IPR036259, MFS_trans_sf
    IPR000109, POT_fam
    IPR018456, PTR2_symporter_CS

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11654, PTHR11654, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00854, PTR2, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF103473, SSF103473, 2 hits

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00924, yjdL_sub1_fam, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50850, MFS, 1 hit
    PS01022, PTR2_1, 1 hit
    PS01023, PTR2_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P39276-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKTPSQPRAI YYIVAIQIWE YFSFYGMRAL LILYLTHQLG FDDNHAISLF 
            60         70         80         90        100
    SAYASLVYVT PILGGWLADR LLGNRTAVIA GALLMTLGHV VLGIDTNSTF 
           110        120        130        140        150
    SLYLALAIII CGYGLFKSNI SCLLGELYDE NDHRRDGGFS LLYAAGNIGS 
           160        170        180        190        200
    IAAPIACGLA AQWYGWHVGF ALAGGGMFIG LLIFLSGHRH FQSTRSMDKK 
           210        220        230        240        250
    ALTSVKFALP VWSWLVVMLC LAPVFFTLLL ENDWSGYLLA IVCLIAAQII 
           260        270        280        290        300
    ARMMIKFPEH RRALWQIVLL MFVGTLFWVL AQQGGSTISL FIDRFVNRQA 
           310        320        330        340        350
    FNIEVPTALF QSVNAIAVML AGVVLAWLAS PESRGNSTLR VWLKFAFGLL 
           360        370        380        390        400
    LMACGFMLLA FDARHAAADG QASMGVMISG LALMGFAELF IDPVAIAQIT 
           410        420        430        440        450
    RLKMSGVLTG IYMLATGAVA NWLAGVVAQQ TTESQISGMA IAAYQRFFSQ 
           460        470        480 
    MGEWTLACVA IIVVLAFATR FLFSTPTNMI QESND
    Length:485
    Mass (Da):53,055
    Last modified:February 1, 1995 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACBE0B947DE0CB61
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U14003 Genomic DNA Translation: AAA97030.1
    U00096 Genomic DNA Translation: AAC77091.1
    AP009048 Genomic DNA Translation: BAE78133.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		S56359

    NCBI Reference Sequences

    More...    RefSeqi    		NP_418554.1, NC_000913.3
    WP_000856829.1, NZ_SSZK01000018.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...    EnsemblBacteriai    		AAC77091; AAC77091; b4130
    BAE78133; BAE78133; BAE78133

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		57730024
    948644

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		ecj:JW4091
    eco:b4130

    Pathosystems Resource Integration Center (PATRIC)

    More...    PATRICi    		fig|511145.12.peg.4262

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U14003 Genomic DNA Translation: AAA97030.1
    U00096 Genomic DNA Translation: AAC77091.1
    AP009048 Genomic DNA Translation: BAE78133.1
    PIRiS56359
    RefSeqiNP_418554.1, NC_000913.3
    WP_000856829.1, NZ_SSZK01000018.1

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi4261129, 143 interactors
    STRINGi511145.b4130

    Protein family/group databases

    TCDBi2.A.17.1.5, the proton-dependent oligopeptide transporter (pot/ptr) family

    Proteomic databases

    PaxDbiP39276
    PRIDEiP39276

    Genome annotation databases

    EnsemblBacteriaiAAC77091; AAC77091; b4130
    BAE78133; BAE78133; BAE78133
    GeneIDi57730024
    948644
    KEGGiecj:JW4091
    eco:b4130
    PATRICifig|511145.12.peg.4262

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...    EchoBASEi    		EB2362

    Phylogenomic databases

    eggNOGiCOG3104, Bacteria
    HOGENOMiCLU_004790_0_0_6
    InParanoidiP39276
    PhylomeDBiP39276

    Enzyme and pathway databases

    BioCyciEcoCyc:YJDL-MONOMER
    MetaCyc:YJDL-MONOMER
    BRENDAi3.6.3.43, 2026

    Miscellaneous databases

    Protein Ontology

    More...    PROi    		PR:P39276

    Family and domain databases

    CDDicd17346, MFS_DtpA_like, 1 hit
    InterProiView protein in InterPro
    IPR005279, Dipep/tripep_permease
    IPR020846, MFS_dom
    IPR036259, MFS_trans_sf
    IPR000109, POT_fam
    IPR018456, PTR2_symporter_CS
    PANTHERiPTHR11654, PTHR11654, 1 hit
    PfamiView protein in Pfam
    PF00854, PTR2, 1 hit
    SUPFAMiSSF103473, SSF103473, 2 hits
    TIGRFAMsiTIGR00924, yjdL_sub1_fam, 1 hit
    PROSITEiView protein in PROSITE
    PS50850, MFS, 1 hit
    PS01022, PTR2_1, 1 hit
    PS01023, PTR2_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTPC_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39276
    Secondary accession number(s): Q2M6H3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: April 7, 2021
    This is version 153 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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