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UniProtKB - P39196 (LPLT_ECOLI)

Entry version 133 (02 Jun 2021)
Sequence version 2 (01 Nov 1997)
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Protein

Lysophospholipid transporter LplT

Gene

lplT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • glycerophospholipid metabolic process Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12455-MONOMER
MetaCyc:EG12455-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.42.1, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophospholipid transporter LplT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lplT
Synonyms:ygeD
Ordered Locus Names:b2835, JW2803
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17PeriplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 52CytoplasmicSequence analysisAdd BLAST14
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 90PeriplasmicSequence analysisAdd BLAST17
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 144CytoplasmicSequence analysisAdd BLAST33
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166PeriplasmicSequence analysis1
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 226CytoplasmicSequence analysisAdd BLAST39
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 256PeriplasmicSequence analysis9
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 280CytoplasmicSequence analysis3
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 304PeriplasmicSequence analysis3
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 343CytoplasmicSequence analysisAdd BLAST18
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 366PeriplasmicSequence analysis2
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 397CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001693381 – 397Lysophospholipid transporter LplTAdd BLAST397

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P39196

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39196

PRoteomics IDEntifications database

More...PRIDEi		P39196

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263140, 265 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0477, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047399_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39196

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39196

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_01585, MFS_LplT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023727, LysoPLipid__transptr_LplT
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39196-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESVHTNTS LWSKGMKAVI VAQFLSAFGD NALLFATLAL LKAQFYPEWS 
        60         70         80         90        100
QPILQMVFVG AYILFAPFVG QVADSFAKGR VMMFANGLKL LGAASICFGI 
       110        120        130        140        150
NPFLGYTLVG VGAAAYSPAK YGILGELTTG SKLVKANGLM EASTIAAILL 
       160        170        180        190        200
GSVAGGVLAD WHVLVALAAC ALAYGGAVVA NIYIPKLAAA RPGQSWNLIN 
       210        220        230        240        250
MTRSFLNACT SLWRNGETRF SLVGTSLFWG AGVTLRFLLV LWVPVALGIT 
       260        270        280        290        300
DNATPTYLNA MVAIGIVVGA GAAAKLVTLE TVSRCMPAGI LIGVVVLIFS 
       310        320        330        340        350
LQHELLPAYA LLMLIGVMGG FFVVPLNALL QERGKKSVGA GNAIAVQNLG 
       360        370        380        390 
ENSAMLLMLG IYSLAVMIGI PVVPIGIGFG ALFALAITAL WIWQRRH
Length:397
Mass (Da):41,656
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BB3B0DEA7FF534C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence L14681 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U29581 Genomic DNA Translation: AAB40482.1
U00096 Genomic DNA Translation: AAC75874.1
AP009048 Genomic DNA Translation: BAE76904.1
L14681 Unassigned DNA No translation available.

Protein sequence database of the Protein Information Resource

More...PIRi		D65066

NCBI Reference Sequences

More...RefSeqi		NP_417312.1, NC_000913.3
WP_000004616.1, NZ_STEB01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75874; AAC75874; b2835
BAE76904; BAE76904; BAE76904

Database of genes from NCBI RefSeq genomes

More...GeneIDi		61754171
947317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2803
eco:b2835

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3899

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA Translation: AAB40482.1
U00096 Genomic DNA Translation: AAC75874.1
AP009048 Genomic DNA Translation: BAE76904.1
L14681 Unassigned DNA No translation available.
PIRiD65066
RefSeqiNP_417312.1, NC_000913.3
WP_000004616.1, NZ_STEB01000034.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4263140, 265 interactors
STRINGi511145.b2835

Protein family/group databases

TCDBi2.A.1.42.1, the major facilitator superfamily (mfs)

Proteomic databases

jPOSTiP39196
PaxDbiP39196
PRIDEiP39196

Genome annotation databases

EnsemblBacteriaiAAC75874; AAC75874; b2835
BAE76904; BAE76904; BAE76904
GeneIDi61754171
947317
KEGGiecj:JW2803
eco:b2835
PATRICifig|1411691.4.peg.3899

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2349

Phylogenomic databases

eggNOGiCOG0477, Bacteria
HOGENOMiCLU_047399_0_0_6
InParanoidiP39196
PhylomeDBiP39196

Enzyme and pathway databases

BioCyciEcoCyc:EG12455-MONOMER
MetaCyc:EG12455-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P39196

Family and domain databases

HAMAPiMF_01585, MFS_LplT, 1 hit
InterProiView protein in InterPro
IPR023727, LysoPLipid__transptr_LplT
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPLT_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39196
Secondary accession number(s): Q2MA02, Q46934
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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