UniProtKB - P39196 (LPLT_ECOLI)
Protein
Lysophospholipid transporter LplT
Gene
lplT
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.1 Publication
GO - Molecular functioni
- lysophospholipid:sodium symporter activity Source: InterPro
GO - Biological processi
- glycerophospholipid metabolic process Source: EcoCyc
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12455-MONOMER MetaCyc:EG12455-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.42.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipid transporter LplT |
Gene namesi | Name:lplT Synonyms:ygeD Ordered Locus Names:b2835, JW2803 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 52 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 90 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 144 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 166 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 226 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 256 | PeriplasmicSequence analysis | 9 | |
Transmembranei | 257 – 277 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 278 – 280 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 304 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 343 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 365 – 366 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 367 – 387 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 388 – 397 | CytoplasmicSequence analysis | 10 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169338 | 1 – 397 | Lysophospholipid transporter LplTAdd BLAST | 397 |
Proteomic databases
jPOSTi | P39196 |
PaxDbi | P39196 |
PRIDEi | P39196 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263140, 265 interactors |
STRINGi | 511145.b2835 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_047399_0_0_6 |
InParanoidi | P39196 |
PhylomeDBi | P39196 |
Family and domain databases
HAMAPi | MF_01585, MFS_LplT, 1 hit |
InterProi | View protein in InterPro IPR023727, LysoPLipid__transptr_LplT IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
i Sequence
Sequence statusi: Complete.
P39196-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESVHTNTS LWSKGMKAVI VAQFLSAFGD NALLFATLAL LKAQFYPEWS
60 70 80 90 100
QPILQMVFVG AYILFAPFVG QVADSFAKGR VMMFANGLKL LGAASICFGI
110 120 130 140 150
NPFLGYTLVG VGAAAYSPAK YGILGELTTG SKLVKANGLM EASTIAAILL
160 170 180 190 200
GSVAGGVLAD WHVLVALAAC ALAYGGAVVA NIYIPKLAAA RPGQSWNLIN
210 220 230 240 250
MTRSFLNACT SLWRNGETRF SLVGTSLFWG AGVTLRFLLV LWVPVALGIT
260 270 280 290 300
DNATPTYLNA MVAIGIVVGA GAAAKLVTLE TVSRCMPAGI LIGVVVLIFS
310 320 330 340 350
LQHELLPAYA LLMLIGVMGG FFVVPLNALL QERGKKSVGA GNAIAVQNLG
360 370 380 390
ENSAMLLMLG IYSLAVMIGI PVVPIGIGFG ALFALAITAL WIWQRRH
Sequence cautioni
The sequence L14681 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29581 Genomic DNA Translation: AAB40482.1 U00096 Genomic DNA Translation: AAC75874.1 AP009048 Genomic DNA Translation: BAE76904.1 L14681 Unassigned DNA No translation available. |
PIRi | D65066 |
RefSeqi | NP_417312.1, NC_000913.3 WP_000004616.1, NZ_STEB01000034.1 |
Genome annotation databases
EnsemblBacteriai | AAC75874; AAC75874; b2835 BAE76904; BAE76904; BAE76904 |
GeneIDi | 947317 |
KEGGi | ecj:JW2803 eco:b2835 |
PATRICi | fig|1411691.4.peg.3899 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29581 Genomic DNA Translation: AAB40482.1 U00096 Genomic DNA Translation: AAC75874.1 AP009048 Genomic DNA Translation: BAE76904.1 L14681 Unassigned DNA No translation available. |
PIRi | D65066 |
RefSeqi | NP_417312.1, NC_000913.3 WP_000004616.1, NZ_STEB01000034.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263140, 265 interactors |
STRINGi | 511145.b2835 |
Protein family/group databases
TCDBi | 2.A.1.42.1, the major facilitator superfamily (mfs) |
Proteomic databases
jPOSTi | P39196 |
PaxDbi | P39196 |
PRIDEi | P39196 |
Genome annotation databases
EnsemblBacteriai | AAC75874; AAC75874; b2835 BAE76904; BAE76904; BAE76904 |
GeneIDi | 947317 |
KEGGi | ecj:JW2803 eco:b2835 |
PATRICi | fig|1411691.4.peg.3899 |
Organism-specific databases
EchoBASEi | EB2349 |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_047399_0_0_6 |
InParanoidi | P39196 |
PhylomeDBi | P39196 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12455-MONOMER MetaCyc:EG12455-MONOMER |
Miscellaneous databases
PROi | PR:P39196 |
Family and domain databases
HAMAPi | MF_01585, MFS_LplT, 1 hit |
InterProi | View protein in InterPro IPR023727, LysoPLipid__transptr_LplT IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LPLT_ECOLI | |
Accessioni | P39196Primary (citable) accession number: P39196 Secondary accession number(s): Q2MA02, Q46934 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families