Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-mannonate oxidoreductase

Gene

uxuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-mannonate + NAD+ = D-fructuronate + NADH.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 36NADBy similarityAdd BLAST12

GO - Molecular functioni

  • coenzyme binding Source: InterPro
  • fructuronate reductase activity Source: CACAO

GO - Biological processi

  • D-glucuronate catabolic process Source: EcoCyc
  • mannitol metabolic process Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:MANNONOXIDOREDUCT-MONOMER
MetaCyc:MANNONOXIDOREDUCT-MONOMER
UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
D-mannonate oxidoreductase (EC:1.1.1.57)
Alternative name(s):
Fructuronate reductase
Gene namesi
Name:uxuB
Ordered Locus Names:b4323, JW4286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20248 uxuB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707471 – 486D-mannonate oxidoreductaseAdd BLAST486

Proteomic databases

EPDiP39160
PaxDbiP39160
PRIDEiP39160

Interactioni

Protein-protein interaction databases

BioGridi4260999, 6 interactors
DIPiDIP-11109N
IntActiP39160, 3 interactors
STRINGi316407.85677066

Structurei

3D structure databases

ProteinModelPortaliP39160
SMRiP39160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DEI Bacteria
COG0246 LUCA
HOGENOMiHOG000202982
InParanoidiP39160
KOiK00040
OMAiWGICEIN
PhylomeDBiP39160

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR000669 Mannitol_DH
IPR013118 Mannitol_DH_C
IPR023027 Mannitol_DH_CS
IPR013131 Mannitol_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01232 Mannitol_dh, 1 hit
PF08125 Mannitol_dh_C, 1 hit
PRINTSiPR00084 MTLDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00974 MANNITOL_DHGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P39160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIVDSNLP VARPSWDHSR LESRIVHLGC GAFHRAHQAL YTHHLLESTD
60 70 80 90 100
SDWGICEVNL MPGNDRVLIE NLKKQQLLYT VAEKGAESTE LKIIGSMKEA
110 120 130 140 150
LHPEIDGCEG ILNAMARPQT AIVSLTVTEK GYCADAASGQ LDLNNPLIKH
160 170 180 190 200
DLENPTAPKS AIGYIVEALR LRREKGLKAF TVMSCDNVRE NGHVAKVAVL
210 220 230 240 250
GLAQARDPQL AAWIEENVTF PCTMVDRIVP AATPETLQEI ADQLGVYDPC
260 270 280 290 300
AIACEPFRQW VIEDNFVNGR PDWDKVGAQF VADVVPFEMM KLRMLNGSHS
310 320 330 340 350
FLAYLGYLGG YETIADTVTN PAYRKAAFAL MMQEQAPTLS MPEGTDLNAY
360 370 380 390 400
ATLLIERFSN PSLRHRTWQI AMDGSQKLPQ RLLDPVRLHL QNGGSWRHLA
410 420 430 440 450
LGVAGWMRYT QGVDEQGNAI DVVDPMLAEF QKINAQYQGA DRVKALLGLS
460 470 480
GIFADDLPQN ADFVGAVTAA YQQLCERGAR ECVAAL
Length:486
Mass (Da):53,580
Last modified:February 1, 1995 - v1
Checksum:i7835638682AF7B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13329 Genomic DNA Translation: BAA02591.1
U14003 Genomic DNA Translation: AAA97219.1
U00096 Genomic DNA Translation: AAC77279.1
AP009048 Genomic DNA Translation: BAE78316.1
PIRiS56548
RefSeqiNP_418743.1, NC_000913.3
WP_000208205.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77279; AAC77279; b4323
BAE78316; BAE78316; BAE78316
GeneIDi946795
KEGGiecj:JW4286
eco:b4323
PATRICifig|1411691.4.peg.2369

Similar proteinsi

Entry informationi

Entry nameiUXUB_ECOLI
AccessioniPrimary (citable) accession number: P39160
Secondary accession number(s): Q2M5Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health