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Protein

V-type proton ATPase subunit F

Gene

VMA7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Miscellaneous

Present with 4050 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • vacuolar acidification Source: SGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30746-MONOMER
ReactomeiR-SCE-1222556 ROS, RNS production in phagocytes
R-SCE-77387 Insulin receptor recycling
R-SCE-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:VMA7
Ordered Locus Names:YGR020C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR020C
SGDiS000003252 VMA7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448121 – 118V-type proton ATPase subunit FAdd BLAST118

Proteomic databases

MaxQBiP39111
PaxDbiP39111
PRIDEiP39111
TopDownProteomicsiP39111

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33262, 60 interactors
ComplexPortaliCPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant
CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
DIPiDIP-2077N
IntActiP39111, 26 interactors
MINTiP39111
STRINGi4932.YGR020C

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi7 – 13Combined sources7
Helixi14 – 22Combined sources9
Turni23 – 26Combined sources4
Turni30 – 32Combined sources3
Beta strandi37 – 40Combined sources4
Turni42 – 44Combined sources3
Helixi47 – 59Combined sources13
Beta strandi62 – 69Combined sources8
Helixi71 – 76Combined sources6
Helixi78 – 82Combined sources5
Beta strandi86 – 93Combined sources8
Helixi108 – 115Combined sources8

3D structure databases

ProteinModelPortaliP39111
SMRiP39111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013208
HOGENOMiHOG000056545
InParanoidiP39111
KOiK02151
OMAiQNVAEMI
OrthoDBiEOG092C5L7Q

Family and domain databases

Gene3Di3.40.50.10580, 1 hit
InterProiView protein in InterPro
IPR008218 ATPase_V1-cplx_f_g_su
IPR005772 ATPase_V1-cplx_fsu_euk
IPR036906 ATPase_V1_fsu_sf
PfamiView protein in Pfam
PF01990 ATP-synt_F, 1 hit
PIRSFiPIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMiSSF159468 SSF159468, 1 hit
TIGRFAMsiTIGR01101 V_ATP_synt_F, 1 hit

Sequencei

Sequence statusi: Complete.

P39111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKRTLIAV IADEDTTTGL LLAGIGQITP ETQEKNFFVY QEGKTTKEEI
60 70 80 90 100
TDKFNHFTEE RDDIAILLIN QHIAENIRAR VDSFTNAFPA ILEIPSKDHP
110
YDPEKDSVLK RVRKLFGE
Length:118
Mass (Da):13,461
Last modified:February 1, 1995 - v1
Checksum:iD21EC0980EB99DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10073 Genomic DNA Translation: AAA50753.1
U12786 Genomic DNA Translation: AAA53208.1
Z72805 Genomic DNA Translation: CAA97003.1
BK006941 Genomic DNA Translation: DAA08116.1
PIRiA55118
RefSeqiNP_011534.1, NM_001181149.1

Genome annotation databases

EnsemblFungiiYGR020C; YGR020C; YGR020C
GeneIDi852903
KEGGisce:YGR020C

Similar proteinsi

Entry informationi

Entry nameiVATF_YEAST
AccessioniPrimary (citable) accession number: P39111
Secondary accession number(s): D6VUF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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