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Protein

T-complex protein 1 subunit delta

Gene

CCT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

Miscellaneous

Present with 5530 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29540-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:CCT4
Synonyms:ANC2, TCP4
Ordered Locus Names:YDL143W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL143W
SGDiS000002302 CCT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283451 – 528T-complex protein 1 subunit deltaAdd BLAST528

Proteomic databases

MaxQBiP39078
PaxDbiP39078
PRIDEiP39078

PTM databases

iPTMnetiP39078

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31918, 354 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-6753N
IntActiP39078, 50 interactors
MINTiP39078
STRINGi4932.YDL143W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80D/L/d/l1-528[»]
4V8RX-ray3.80AD/Ad/BD/Bd1-528[»]
4V94X-ray3.80D/L/d/l1-528[»]
5GW4electron microscopy4.70D/d1-528[»]
5GW5electron microscopy4.60D/d1-528[»]
ProteinModelPortaliP39078
SMRiP39078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
InParanoidiP39078
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG092C1WYZ

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P39078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKVPSNAT FKNKEKPQEV RKANIIAARS VADAIRTSLG PKGMDKMIKT
60 70 80 90 100
SRGEIIISND GHTILKQMAI LHPVARMLVE VSAAQDSEAG DGTTSVVILT
110 120 130 140 150
GALLGAAERL LNKGIHPTII ADSFQSAAKR SVDILLEMCH KVSLSDREQL
160 170 180 190 200
VRAASTSLSS KIVSQYSSFL APLAVDSVLK ISDENSKNVD LNDIRLVKKV
210 220 230 240 250
GGTIDDTEMI DGVVLTQTAI KSAGGPTRKE KAKIGLIQFQ ISPPKPDTEN
260 270 280 290 300
NIIVNDYRQM DKILKEERAY LLNICKKIKK AKCNVLLIQK SILRDAVNDL
310 320 330 340 350
ALHFLSKLNI MVVKDIEREE IEFLSKGLGC KPIADIELFT EDRLGSADLV
360 370 380 390 400
EEIDSDGSKI VRVTGIRNNN ARPTVSVVIR GANNMIIDET ERSLHDALCV
410 420 430 440 450
IRCLVKERGL IAGGGAPEIE ISRRLSKEAR SMEGVQAFIW QEFASALEVI
460 470 480 490 500
PTTLAENAGL NSIKVVTELR SKHENGELND GISVRRSGTT NTYEEHILQP
510 520
VLVSTSAITL ASECVKSILR IDDIAFSR
Length:528
Mass (Da):57,604
Last modified:November 1, 1997 - v2
Checksum:iF01146D76F4E850C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254V → A in CAA83912 (PubMed:7916461).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33504 Genomic DNA Translation: CAA83912.1
Z74191 Genomic DNA Translation: CAA98716.1
BK006938 Genomic DNA Translation: DAA11715.1
PIRiS67690
RefSeqiNP_010138.1, NM_001180203.1

Genome annotation databases

EnsemblFungiiYDL143W; YDL143W; YDL143W
GeneIDi851412
KEGGisce:YDL143W

Similar proteinsi

Entry informationi

Entry nameiTCPD_YEAST
AccessioniPrimary (citable) accession number: P39078
Secondary accession number(s): D6VRK5, Q07561
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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