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Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31392-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6798695 Neutrophil degranulation
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:CCT2
Synonyms:BIN3, TCP2
Ordered Locus Names:YIL142W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

SGDiS000001404 CCT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001283202 – 527T-complex protein 1 subunit betaAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP39076
PaxDbiP39076
PRIDEiP39076

PTM databases

iPTMnetiP39076

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34850, 258 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-4451N
IntActiP39076, 51 interactors
MINTiP39076
STRINGi4932.YIL142W

Structurei

3D structure databases

ProteinModelPortaliP39076
SMRiP39076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
InParanoidiP39076
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG092C1WYZ

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39076-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQIFGDQV TEERAENARL SAFVGAIAVG DLVKSTLGPK GMDKLLQSAS
60 70 80 90 100
SNTCMVTNDG ATILKSIPLD NPAAKVLVNI SKVQDDEVGD GTTSVTVLSA
110 120 130 140 150
ELLREAEKLI DQSKIHPQTI IEGYRLASAA ALDALTKAAV DNSHDKTMFR
160 170 180 190 200
EDLIHIAKTT LSSKILSQDK DHFAELATNA ILRLKGSTNL EHIQIIKILG
210 220 230 240 250
GKLSDSFLDE GFILAKKFGN NQPKRIENAK ILIANTTLDT DKVKIFGTKF
260 270 280 290 300
KVDSTAKLAQ LEKAEREKMK NKIAKISKFG INTFINRQLI YDYPEQLFTD
310 320 330 340 350
LGINSIEHAD FEGVERLALV TGGEVVSTFD EPSKCKLGEC DVIEEIMLGE
360 370 380 390 400
QPFLKFSGCK AGEACTIVLR GATDQTLDEA ERSLHDALSV LSQTTKETRT
410 420 430 440 450
VLGGGCAEMV MSKAVDTEAQ NIDGKKSLAV EAFARALRQL PTILADNAGF
460 470 480 490 500
DSSELVSKLR SSIYNGISTS GLDLNNGTIA DMRQLGIVES YKLKRAVVSS
510 520
ASEAAEVLLR VDNIIRARPR TANRQHM
Length:527
Mass (Da):57,203
Last modified:February 1, 1995 - v1
Checksum:iC5DB2BC3660EC7E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77675 Genomic DNA Translation: CAA54745.1
U16761 Genomic DNA Translation: AAA53433.1
Z38059 Genomic DNA Translation: CAA86136.1
AY723831 Genomic DNA Translation: AAU09748.1
U49845 Genomic DNA Translation: AAA98665.1
BK006942 Genomic DNA Translation: DAA08411.1
PIRiS48232
RefSeqiNP_012124.1, NM_001179490.1

Genome annotation databases

EnsemblFungiiYIL142W; YIL142W; YIL142W
GeneIDi854664
KEGGisce:YIL142W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77675 Genomic DNA Translation: CAA54745.1
U16761 Genomic DNA Translation: AAA53433.1
Z38059 Genomic DNA Translation: CAA86136.1
AY723831 Genomic DNA Translation: AAU09748.1
U49845 Genomic DNA Translation: AAA98665.1
BK006942 Genomic DNA Translation: DAA08411.1
PIRiS48232
RefSeqiNP_012124.1, NM_001179490.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80B/J/b/j1-527[»]
4V8RX-ray3.80AB/Ab/BB/Bb1-527[»]
4V94X-ray3.80B/J/b/j1-527[»]
5GW4electron microscopy4.70B/b1-527[»]
5GW5electron microscopy4.60B/b1-527[»]
ProteinModelPortaliP39076
SMRiP39076
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34850, 258 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-4451N
IntActiP39076, 51 interactors
MINTiP39076
STRINGi4932.YIL142W

PTM databases

iPTMnetiP39076

Proteomic databases

MaxQBiP39076
PaxDbiP39076
PRIDEiP39076

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL142W; YIL142W; YIL142W
GeneIDi854664
KEGGisce:YIL142W

Organism-specific databases

SGDiS000001404 CCT2

Phylogenomic databases

GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
InParanoidiP39076
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG092C1WYZ

Enzyme and pathway databases

BioCyciYEAST:G3O-31392-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6798695 Neutrophil degranulation
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:P39076

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPB_YEAST
AccessioniPrimary (citable) accession number: P39076
Secondary accession number(s): D6VVE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
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Main funding by: National Institutes of Health

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