UniProtKB - P39076 (TCPB_YEAST)

BLAST

>sp|P39076|TCPB_YEAST T-complex protein 1 subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CCT2 PE=1 SV=1
MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDG
ATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTI
IEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNA
ILRLKGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDT
DKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTD
LGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCK
AGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQ
NIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIA
DMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM

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History
Entry version 166 (07 Nov 2018)
Sequence version 1 (01 Feb 1995)
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Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
unfolded protein binding
Source: SGD
Inferred from direct assayⁱ
- 16762366

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding
Source: SGD
Inferred from direct assayⁱ
- 16762366

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31392-MONOMER
Reactomeⁱ	R-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis R-SCE-6798695 Neutrophil degranulation R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-complex protein 1 subunit beta Short name: TCP-1-beta Alternative name(s): CCT-beta
Gene namesⁱ	Name:CCT2 Synonyms:BIN3, TCP2 Ordered Locus Names:YIL142W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000001404 CCT2

SGDⁱ

S000001404 CCT2

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000128320	2 – 527	T-complex protein 1 subunit betaAdd BLAST		526

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P39076
PaxDbⁱ	P39076
PRIDEⁱ	P39076

PTM databases

iPTMnetⁱ	P39076

iPTMnetⁱ

P39076

Interactionⁱ

Subunit structureⁱ

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functionⁱ

unfolded protein binding
Source: SGD
Inferred from direct assayⁱ
- 16762366

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	34850, 258 interactors
ComplexPortalⁱ	CPX-2156 Chaperonin-containing T-complex
Database of interacting proteins More...DIPⁱ	DIP-4451N
IntActⁱ	P39076, 51 interactors
Molecular INTeraction database More...MINTⁱ	P39076
STRINGⁱ	4932.YIL142W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P39076
SMRⁱ	P39076
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074930
HOGENOMⁱ	HOG000226736
InParanoidⁱ	P39076
KEGG Orthology (KO) More...KOⁱ	K09494
OMAⁱ	PGVHQPQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1WYZ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03336 TCP1_beta, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012716 Chap_CCT_beta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
PANTHERⁱ	PTHR11353:SF23 PTHR11353:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02341 chap_CCT_beta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P39076-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVQIFGDQV TEERAENARL SAFVGAIAVG DLVKSTLGPK GMDKLLQSAS 
        60         70         80         90        100
SNTCMVTNDG ATILKSIPLD NPAAKVLVNI SKVQDDEVGD GTTSVTVLSA 
       110        120        130        140        150
ELLREAEKLI DQSKIHPQTI IEGYRLASAA ALDALTKAAV DNSHDKTMFR 
       160        170        180        190        200
EDLIHIAKTT LSSKILSQDK DHFAELATNA ILRLKGSTNL EHIQIIKILG 
       210        220        230        240        250
GKLSDSFLDE GFILAKKFGN NQPKRIENAK ILIANTTLDT DKVKIFGTKF 
       260        270        280        290        300
KVDSTAKLAQ LEKAEREKMK NKIAKISKFG INTFINRQLI YDYPEQLFTD 
       310        320        330        340        350
LGINSIEHAD FEGVERLALV TGGEVVSTFD EPSKCKLGEC DVIEEIMLGE 
       360        370        380        390        400
QPFLKFSGCK AGEACTIVLR GATDQTLDEA ERSLHDALSV LSQTTKETRT 
       410        420        430        440        450
VLGGGCAEMV MSKAVDTEAQ NIDGKKSLAV EAFARALRQL PTILADNAGF 
       460        470        480        490        500
DSSELVSKLR SSIYNGISTS GLDLNNGTIA DMRQLGIVES YKLKRAVVSS 
       510        520 
ASEAAEVLLR VDNIIRARPR TANRQHM

Length:527

Mass (Da):57,203

Last modified:February 1, 1995 - v1

Checksum:ⁱC5DB2BC3660EC7E6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77675 Genomic DNA Translation: CAA54745.1 U16761 Genomic DNA Translation: AAA53433.1 Z38059 Genomic DNA Translation: CAA86136.1 AY723831 Genomic DNA Translation: AAU09748.1 U49845 Genomic DNA Translation: AAA98665.1 BK006942 Genomic DNA Translation: DAA08411.1
PIRⁱ	S48232
NCBI Reference Sequences More...RefSeqⁱ	NP_012124.1, NM_001179490.1

Genome annotation databases

EnsemblFungiⁱ	YIL142W; YIL142W; YIL142W
GeneIDⁱ	854664
KEGGⁱ	sce:YIL142W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P39076	T-complex protein 1 subunit beta		YEAS1		527	UniRef100_P39076
CCT2p Subunit beta of the cytosolic chaperonin Cct ring complex		Saccharomyces sp. 'boulardii'		527
YIL142Wp-like protein		YEAS6		527
Cct2p		YEASZ		527

Protein	Similar proteins		Species	Score	Length	Source
P39076	T-complex protein 1 subunit beta		YEAS1		527	UniRef90_P39076
CCT2p Subunit beta of the cytosolic chaperonin Cct ring complex		Saccharomyces sp. 'boulardii'		527
YIL142Wp-like protein		YEAS6		527
Cct2p		YEASZ		527
CCT2-like protein		SACEU		527
+16

Protein	Similar proteins		Species	Score	Length	Source
P39076	Probable T-complex protein 1 subunit beta		SCHPO		527	UniRef50_P39076
T-complex protein 1 subunit beta		YEAS1		527
CCT2p Subunit beta of the cytosolic chaperonin Cct ring complex		Saccharomyces sp. 'boulardii'		527
YIL142Wp-like protein		YEAS6		527
Cct2p		YEASZ		527
+411

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77675 Genomic DNA Translation: CAA54745.1 U16761 Genomic DNA Translation: AAA53433.1 Z38059 Genomic DNA Translation: CAA86136.1 AY723831 Genomic DNA Translation: AAU09748.1 U49845 Genomic DNA Translation: AAA98665.1 BK006942 Genomic DNA Translation: DAA08411.1
PIRⁱ	S48232
RefSeqⁱ	NP_012124.1, NM_001179490.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4V81	X-ray	3.80	B/J/b/j	1-527	[»]
	4V8R	X-ray	3.80	AB/Ab/BB/Bb	1-527	[»]
	4V94	X-ray	3.80	B/J/b/j	1-527	[»]
	5GW4	electron microscopy	4.70	B/b	1-527	[»]
	5GW5	electron microscopy	4.60	B/b	1-527	[»]
ProteinModelPortalⁱ	P39076
SMRⁱ	P39076
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	34850, 258 interactors
ComplexPortalⁱ	CPX-2156 Chaperonin-containing T-complex
DIPⁱ	DIP-4451N
IntActⁱ	P39076, 51 interactors
MINTⁱ	P39076
STRINGⁱ	4932.YIL142W

PTM databases

iPTMnetⁱ	P39076

iPTMnetⁱ

P39076

Proteomic databases

MaxQBⁱ	P39076
PaxDbⁱ	P39076
PRIDEⁱ	P39076

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YIL142W; YIL142W; YIL142W
GeneIDⁱ	854664
KEGGⁱ	sce:YIL142W

Organism-specific databases

SGDⁱ	S000001404 CCT2

Phylogenomic databases

GeneTreeⁱ	ENSGT00550000074930
HOGENOMⁱ	HOG000226736
InParanoidⁱ	P39076
KOⁱ	K09494
OMAⁱ	PGVHQPQ
OrthoDBⁱ	EOG092C1WYZ

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31392-MONOMER
Reactomeⁱ	R-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis R-SCE-6798695 Neutrophil degranulation R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P39076

PROⁱ

PR:P39076

Family and domain databases

CDDⁱ	cd03336 TCP1_beta, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012716 Chap_CCT_beta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
PANTHERⁱ	PTHR11353:SF23 PTHR11353:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02341 chap_CCT_beta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCPB_YEAST
Accessionⁱ	P39076Primary (citable) accession number: P39076 Secondary accession number(s): D6VVE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - P39076 (TCPB_YEAST)

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T-complex protein 1 subunit beta

CCT2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ