UniProtKB - P39076 (TCPB_YEAST)
Protein
T-complex protein 1 subunit beta
Gene
CCT2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: SGD
GO - Biological processi
- protein folding Source: SGD
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-390471, Association of TriC/CCT with target proteins during biosynthesis R-SCE-6798695, Neutrophil degranulation R-SCE-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit betaShort name: TCP-1-beta Alternative name(s): CCT-beta |
Gene namesi | Name:CCT2 Synonyms:BIN3, TCP2 Ordered Locus Names:YIL142W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001404, CCT2 |
VEuPathDBi | FungiDB:YIL142W |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- chaperonin-containing T-complex Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000128320 | 2 – 527 | T-complex protein 1 subunit betaAdd BLAST | 526 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | P39076 |
PaxDbi | P39076 |
PRIDEi | P39076 |
PTM databases
iPTMneti | P39076 |
Interactioni
Subunit structurei
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (By similarity).
Interacts with PLP2; this interaction leads to inhibition of CCT complex mediated actin folding (PubMed:17429077).
By similarity1 PublicationGO - Molecular functioni
- unfolded protein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34850, 269 interactors |
ComplexPortali | CPX-2156, Chaperonin-containing T-complex |
DIPi | DIP-4451N |
IntActi | P39076, 51 interactors |
MINTi | P39076 |
STRINGi | 4932.YIL142W |
Miscellaneous databases
RNActi | P39076, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P39076 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0363, Eukaryota |
GeneTreei | ENSGT00550000074930 |
HOGENOMi | CLU_008891_6_2_1 |
InParanoidi | P39076 |
OMAi | HQPQRIE |
Family and domain databases
CDDi | cd03336, TCP1_beta, 1 hit |
Gene3Di | 1.10.560.10, 2 hits 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012716, Chap_CCT_beta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF23, PTHR11353:SF23, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02341, chap_CCT_beta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P39076-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVQIFGDQV TEERAENARL SAFVGAIAVG DLVKSTLGPK GMDKLLQSAS
60 70 80 90 100
SNTCMVTNDG ATILKSIPLD NPAAKVLVNI SKVQDDEVGD GTTSVTVLSA
110 120 130 140 150
ELLREAEKLI DQSKIHPQTI IEGYRLASAA ALDALTKAAV DNSHDKTMFR
160 170 180 190 200
EDLIHIAKTT LSSKILSQDK DHFAELATNA ILRLKGSTNL EHIQIIKILG
210 220 230 240 250
GKLSDSFLDE GFILAKKFGN NQPKRIENAK ILIANTTLDT DKVKIFGTKF
260 270 280 290 300
KVDSTAKLAQ LEKAEREKMK NKIAKISKFG INTFINRQLI YDYPEQLFTD
310 320 330 340 350
LGINSIEHAD FEGVERLALV TGGEVVSTFD EPSKCKLGEC DVIEEIMLGE
360 370 380 390 400
QPFLKFSGCK AGEACTIVLR GATDQTLDEA ERSLHDALSV LSQTTKETRT
410 420 430 440 450
VLGGGCAEMV MSKAVDTEAQ NIDGKKSLAV EAFARALRQL PTILADNAGF
460 470 480 490 500
DSSELVSKLR SSIYNGISTS GLDLNNGTIA DMRQLGIVES YKLKRAVVSS
510 520
ASEAAEVLLR VDNIIRARPR TANRQHM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77675 Genomic DNA Translation: CAA54745.1 U16761 Genomic DNA Translation: AAA53433.1 Z38059 Genomic DNA Translation: CAA86136.1 AY723831 Genomic DNA Translation: AAU09748.1 U49845 Genomic DNA Translation: AAA98665.1 BK006942 Genomic DNA Translation: DAA08411.1 |
PIRi | S48232 |
RefSeqi | NP_012124.1, NM_001179490.1 |
Genome annotation databases
EnsemblFungii | YIL142W_mRNA; YIL142W; YIL142W |
GeneIDi | 854664 |
KEGGi | sce:YIL142W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77675 Genomic DNA Translation: CAA54745.1 U16761 Genomic DNA Translation: AAA53433.1 Z38059 Genomic DNA Translation: CAA86136.1 AY723831 Genomic DNA Translation: AAU09748.1 U49845 Genomic DNA Translation: AAA98665.1 BK006942 Genomic DNA Translation: DAA08411.1 |
PIRi | S48232 |
RefSeqi | NP_012124.1, NM_001179490.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V81 | X-ray | 3.80 | B/J/b/j | 1-527 | [»] | |
4V8R | X-ray | 3.80 | AB/Ab/BB/Bb | 1-527 | [»] | |
4V94 | X-ray | 3.80 | B/J/b/j | 1-527 | [»] | |
5GW4 | electron microscopy | 4.70 | B/b | 1-527 | [»] | |
5GW5 | electron microscopy | 4.60 | B/b | 1-527 | [»] | |
6KRD | electron microscopy | 4.38 | B/b | 1-527 | [»] | |
6KRE | electron microscopy | 4.45 | B/b | 1-527 | [»] | |
6KS6 | electron microscopy | 2.99 | B/b | 1-527 | [»] | |
6KS7 | electron microscopy | 4.62 | B/b | 1-527 | [»] | |
6KS8 | electron microscopy | 4.69 | B/b | 1-527 | [»] | |
SMRi | P39076 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34850, 269 interactors |
ComplexPortali | CPX-2156, Chaperonin-containing T-complex |
DIPi | DIP-4451N |
IntActi | P39076, 51 interactors |
MINTi | P39076 |
STRINGi | 4932.YIL142W |
PTM databases
iPTMneti | P39076 |
Proteomic databases
MaxQBi | P39076 |
PaxDbi | P39076 |
PRIDEi | P39076 |
Genome annotation databases
EnsemblFungii | YIL142W_mRNA; YIL142W; YIL142W |
GeneIDi | 854664 |
KEGGi | sce:YIL142W |
Organism-specific databases
SGDi | S000001404, CCT2 |
VEuPathDBi | FungiDB:YIL142W |
Phylogenomic databases
eggNOGi | KOG0363, Eukaryota |
GeneTreei | ENSGT00550000074930 |
HOGENOMi | CLU_008891_6_2_1 |
InParanoidi | P39076 |
OMAi | HQPQRIE |
Enzyme and pathway databases
Reactomei | R-SCE-390471, Association of TriC/CCT with target proteins during biosynthesis R-SCE-6798695, Neutrophil degranulation R-SCE-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Miscellaneous databases
PROi | PR:P39076 |
RNActi | P39076, protein |
Family and domain databases
CDDi | cd03336, TCP1_beta, 1 hit |
Gene3Di | 1.10.560.10, 2 hits 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012716, Chap_CCT_beta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF23, PTHR11353:SF23, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02341, chap_CCT_beta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPB_YEAST | |
Accessioni | P39076Primary (citable) accession number: P39076 Secondary accession number(s): D6VVE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families