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Protein

Multidrug-efflux transporter 1 regulator

Gene

bmrR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 27H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU24020-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug-efflux transporter 1 regulator
Gene namesi
Name:bmrR
Synonyms:bmr1R
Ordered Locus Names:BSU24020
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981091 – 278Multidrug-efflux transporter 1 regulatorAdd BLAST278

Proteomic databases

PaxDbiP39075
PRIDEiP39075

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

DIPiDIP-59692N
STRINGi224308.Bsubs1_010100013176

Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP39075
SMRiP39075
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39075

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 75HTH merR-typePROSITE-ProRule annotationAdd BLAST71

Phylogenomic databases

eggNOGiCOG0789 LUCA
COG4978 LUCA
HOGENOMiHOG000050346
KOiK19575
OMAiVEMKIRI
PhylomeDBiP39075

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR029442 GyrI-like
IPR000551 MerR-type_HTH_dom
IPR011256 Reg_factor_effector_dom_sf
PfamiView protein in Pfam
PF06445 GyrI-like, 1 hit
PF13411 MerR_1, 1 hit
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF55136 SSF55136, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39075-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKESYYSIGE VSKLANVSIK ALRYYDKIDL FKPAYVDPDT SYRYYTDSQL
60 70 80 90 100
IHLDLIKSLK YIGTPLEEMK KAQDLEMEEL FAFYTEQERQ IREKLDFLSA
110 120 130 140 150
LEQTISLVKK RMKRQMEYPA LGEVFVLDEE EIRIIQTEAE GIGPENVLNA
160 170 180 190 200
SYSKLKKFIE SADGFTNNSY GATFSFQPYT SIDEMTYRHI FTPVLTNKQI
210 220 230 240 250
SSITPDMEIT TIPKGRYACI AYNFSPEHYF LNLQKLIKYI ADRQLTVVSD
260 270
VYELIIPIHY SPKKQEEYRV EMKIRIAE
Length:278
Mass (Da):32,582
Last modified:October 24, 2003 - v3
Checksum:i184AEF0274991E73
GO

Sequence cautioni

The sequence BAA23495 differs from that shown. Reason: Frameshift at positions 74 and 120.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25604 Genomic DNA Translation: AAB81540.2
D84432 Genomic DNA Translation: BAA23495.1 Sequence problems.
AL009126 Genomic DNA Translation: CAB14333.2
PIRiE69595
RefSeqiNP_390282.2, NC_000964.3
WP_003230325.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14333; CAB14333; BSU24020
GeneIDi938676
KEGGibsu:BSU24020
PATRICifig|224308.179.peg.2616

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25604 Genomic DNA Translation: AAB81540.2
D84432 Genomic DNA Translation: BAA23495.1 Sequence problems.
AL009126 Genomic DNA Translation: CAB14333.2
PIRiE69595
RefSeqiNP_390282.2, NC_000964.3
WP_003230325.1, NZ_JNCM01000036.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOWX-ray2.70A121-278[»]
1EXIX-ray3.12A1-278[»]
1EXJX-ray3.00A1-278[»]
1R8EX-ray2.40A1-278[»]
2BOWX-ray2.80A121-278[»]
3D6YX-ray2.70A1-278[»]
3D6ZX-ray2.60A1-278[»]
3D70X-ray2.80A2-278[»]
3D71X-ray2.80A1-276[»]
3IAOX-ray2.80A1-278[»]
3Q1MX-ray3.20A1-276[»]
3Q2YX-ray2.95A1-276[»]
3Q3DX-ray2.79A1-276[»]
3Q5PX-ray2.94A1-276[»]
3Q5RX-ray3.05A1-276[»]
3Q5SX-ray3.10A1-276[»]
ProteinModelPortaliP39075
SMRiP39075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59692N
STRINGi224308.Bsubs1_010100013176

Proteomic databases

PaxDbiP39075
PRIDEiP39075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14333; CAB14333; BSU24020
GeneIDi938676
KEGGibsu:BSU24020
PATRICifig|224308.179.peg.2616

Phylogenomic databases

eggNOGiCOG0789 LUCA
COG4978 LUCA
HOGENOMiHOG000050346
KOiK19575
OMAiVEMKIRI
PhylomeDBiP39075

Enzyme and pathway databases

BioCyciBSUB:BSU24020-MONOMER

Miscellaneous databases

EvolutionaryTraceiP39075

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR029442 GyrI-like
IPR000551 MerR-type_HTH_dom
IPR011256 Reg_factor_effector_dom_sf
PfamiView protein in Pfam
PF06445 GyrI-like, 1 hit
PF13411 MerR_1, 1 hit
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF55136 SSF55136, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMRR_BACSU
AccessioniPrimary (citable) accession number: P39075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 24, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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Main funding by: National Institutes of Health

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