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UniProtKB - P39071 (DHBA_BACSU)
Protein
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Gene
dhbA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:1.3.1.28
: bacillibactin biosynthesis Pathwayi
This protein is involved in the pathway bacillibactin biosynthesis, which is part of Siderophore biosynthesis.View all proteins of this organism that are known to be involved in the pathway bacillibactin biosynthesis and in Siderophore biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 144 | SubstrateBy similarity | 1 | |
Active sitei | 157 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 36 | NADBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity Source: UniProtKB-EC
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
GO - Biological processi
- cellular response to iron ion Source: CollecTF
- fatty acid elongation Source: GO_Central
- siderophore biosynthetic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Stress response |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | BSUB:BSU32000-MONOMER |
UniPathwayi | UPA00013 |
Names & Taxonomyi
Protein namesi | Recommended name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (EC:1.3.1.28)Alternative name(s): Cold shock protein CSI14 |
Gene namesi | Name:dhbA Synonyms:entA Ordered Locus Names:BSU32000 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054601 | 1 – 261 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenaseAdd BLAST | 261 |
Proteomic databases
jPOSTi | P39071 |
PaxDbi | P39071 |
PRIDEi | P39071 |
Expressioni
Inductioni
In response to low temperature.
Interactioni
Protein-protein interaction databases
IntActi | P39071, 1 interactor |
MINTi | P39071 |
STRINGi | 224308.BSU32000 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
InParanoidi | P39071 |
OMAi | VGTLGKQ |
PhylomeDBi | P39071 |
Family and domain databases
CDDi | cd05331, DH-DHB-DH_SDR_c, 1 hit |
InterProi | View protein in InterPro IPR003560, DHB_DH IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR01397, DHBDHDRGNASE PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR04316, dhbA_paeA, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
P39071-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAKGIEGKI AFITGAAQGI GEAVARTLAS QGAHIAAVDY NPEKLEKVVS
60 70 80 90 100
SLKAEGRHAE AFPADVRDSA AIDEITARIE REMGPIDILV NVAGVLRPGL
110 120 130 140 150
IHSLSDEEWE ATFSVNSTGV FNASRSVSKY MMDRRSGSIV TVGSNAAGVP
160 170 180 190 200
RTSMAAYASS KAAAVMFTKC LGLELAEYNI RCNIVSPGST ETDMQWSLWA
210 220 230 240 250
DENGAEQVIK GSLETFKTGI PLKKLAKPSD IADAVLFLVS GQAGHITMHN
260
LCVDGGATLG V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | G → A in AAC44630 (PubMed:8921902).Curated | 1 | |
Sequence conflicti | 146 | A → D in AAA16899 (PubMed:8224884).Curated | 1 | |
Sequence conflicti | 146 | A → P in AAC44630 (PubMed:8921902).Curated | 1 | |
Sequence conflicti | 231 – 234 | IADA → MRC in AAA16899 (PubMed:8224884).Curated | 4 | |
Sequence conflicti | 247 – 256 | TMHNLCVDGG → RCIFMRRC in AAA16899 (PubMed:8224884).Curated | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26444 Genomic DNA Translation: AAC44630.1 AL009126 Genomic DNA Translation: CAB15190.2 L08644 Genomic DNA Translation: AAA16899.2 |
PIRi | A69615 |
RefSeqi | NP_391080.2, NC_000964.3 WP_003244476.1, NZ_JNCM01000033.1 |
Genome annotation databases
EnsemblBacteriai | CAB15190; CAB15190; BSU_32000 |
GeneIDi | 936579 |
KEGGi | bsu:BSU32000 |
PATRICi | fig|224308.179.peg.3466 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26444 Genomic DNA Translation: AAC44630.1 AL009126 Genomic DNA Translation: CAB15190.2 L08644 Genomic DNA Translation: AAA16899.2 |
PIRi | A69615 |
RefSeqi | NP_391080.2, NC_000964.3 WP_003244476.1, NZ_JNCM01000033.1 |
3D structure databases
SMRi | P39071 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P39071, 1 interactor |
MINTi | P39071 |
STRINGi | 224308.BSU32000 |
Proteomic databases
jPOSTi | P39071 |
PaxDbi | P39071 |
PRIDEi | P39071 |
Genome annotation databases
EnsemblBacteriai | CAB15190; CAB15190; BSU_32000 |
GeneIDi | 936579 |
KEGGi | bsu:BSU32000 |
PATRICi | fig|224308.179.peg.3466 |
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
InParanoidi | P39071 |
OMAi | VGTLGKQ |
PhylomeDBi | P39071 |
Enzyme and pathway databases
UniPathwayi | UPA00013 |
BioCyci | BSUB:BSU32000-MONOMER |
Family and domain databases
CDDi | cd05331, DH-DHB-DH_SDR_c, 1 hit |
InterProi | View protein in InterPro IPR003560, DHB_DH IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR01397, DHBDHDRGNASE PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR04316, dhbA_paeA, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHBA_BACSU | |
Accessioni | P39071Primary (citable) accession number: P39071 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 7, 2009 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families