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Protein

Collagen alpha-1(XVIII) chain

Gene

Col18a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.By similarity
Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.By similarity
Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168). Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087). Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity).By similarity2 Publications

Caution

Non-collagenous domain 1 seems to be the predominant tissue form from which endostatin is cleaved. However, the proteolytic cleavage site to generate non-collagenous domain 1 is not known. Soluble recombinant non-collagenous domain 1 amenable to biochemical studies has been used instead; its molecular wight corresponds to probable non-collagenous domain 1 immunoblot bands seen in tissue extracts.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1591Zinc; alternate1
Metal bindingi1593Zinc1
Metal bindingi1595Zinc; alternate1
Metal bindingi1601Zinc1
Metal bindingi1666Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000157 Laminin interactions
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XVIII) chain
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col18a1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88451 Col18a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1591H → A: No effect on zinc binding. 1 Publication1
Mutagenesisi1593H → A: Reduces zinc binding by 60%. Abolishes zinc binding; when associated with A-1595. 1 Publication1
Mutagenesisi1595D → A: No effect on zinc binding. Abolishes zinc binding; when associated with A-1593. 1 Publication1
Mutagenesisi1666D → A: Abolishes zinc binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000441862? – 1774Non-collagenous domain 1Curated
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000579527 – 1774Collagen alpha-1(XVIII) chainAdd BLAST1748
ChainiPRO_00000057961591 – 1774EndostatinAdd BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi370 ↔ 433PROSITE-ProRule annotation
Disulfide bondi380 ↔ 426PROSITE-ProRule annotation
Disulfide bondi417 ↔ 455PROSITE-ProRule annotation
Disulfide bondi444 ↔ 479PROSITE-ProRule annotation
Disulfide bondi448 ↔ 468PROSITE-ProRule annotation
Glycosylationi585N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei730PhosphothreonineBy similarity1
Glycosylationi947N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1623 ↔ 1763PROSITE-ProRule annotation1 Publication
Disulfide bondi1725 ↔ 1755PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated.
Undergoes proteolytic processing by cathepsin-L and elastase-like proteases to generate both non-collagenous domain 1 trimers and endostatin monomers. In tissue extracts (brain, skeletal muscle, heart, kidney, testis and liver) predominantly bands of approximately 38 kDa are detected; recombinant non-collagenous domain 1 shows similar mobility. In vitro, several proteolytic cleavage sites in the non-collagenous domain 1 hinge region generating different endostatin-like peptides are reported.By similarity1 Publication2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39061

PeptideAtlas

More...
PeptideAtlasi
P39061

PRoteomics IDEntifications database

More...
PRIDEi
P39061

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39061

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P39061

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P39061

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, kidney, lung, skeletal muscle and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001435 Expressed in 322 organ(s), highest expression level in aorta

CleanEx database of gene expression profiles

More...
CleanExi
MM_COL18A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P39061 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P39061 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Non-collagenous domain 1 forms homotrimers. Endostatin is monomeric (PubMed:9687493). Recombinant non-collagenous domain 1 has stronger affinity to NID1, HSPG2 and laminin-1:NID1 complex and lower affinity to FBLN1 and FBLN2 than endostatin (PubMed:10966814). Endostatin interacts with KDR/VEGFR2 (PubMed:12029087). Endostatin interacts with the ITGA5:ITGB1 complex (PubMed:11158588).4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198812, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2996 Collagen type XVIII trimer

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11774
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P39061

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P39061

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P39061

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini365 – 482FZPROSITE-ProRule annotationAdd BLAST118
Domaini522 – 704Laminin G-likeAdd BLAST183
Domaini823 – 878Collagen-like 1Add BLAST56
Domaini953 – 1007Collagen-like 2Add BLAST55
Domaini1008 – 1041Collagen-like 3Add BLAST34
Domaini1066 – 1117Collagen-like 4Add BLAST52
Domaini1118 – 1147Collagen-like 5Add BLAST30
Domaini1162 – 1202Collagen-like 6Add BLAST41
Domaini1216 – 1264Collagen-like 7Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 785Nonhelical region 1 (NC1)Add BLAST759
Regioni786 – 812Triple-helical region 1 (COL1)Add BLAST27
Regioni813 – 822Nonhelical region 2 (NC2)10
Regioni823 – 896Triple-helical region 2 (COL2)Add BLAST74
Regioni897 – 920Nonhelical region 3 (NC3)Add BLAST24
Regioni921 – 1042Triple-helical region 3 (COL3)Add BLAST122
Regioni1043 – 1065Nonhelical region 4 (NC4)Add BLAST23
Regioni1066 – 1148Triple-helical region 4 (COL4)Add BLAST83
Regioni1149 – 1162Nonhelical region 5 (NC5)Add BLAST14
Regioni1163 – 1204Triple-helical region 5 (COL5)Add BLAST42
Regioni1205 – 1217Nonhelical region 6 (NC6)Add BLAST13
Regioni1218 – 1290Triple-helical region 6 (COL6)Add BLAST73
Regioni1291 – 1300Nonhelical region 7 (NC7)10
Regioni1301 – 1333Triple-helical region 7 (COL7)Add BLAST33
Regioni1334 – 1345Nonhelical region 8 (NC8)Add BLAST12
Regioni1346 – 1369Triple-helical region 8 (COL8)Add BLAST24
Regioni1370 – 1376Nonhelical region 9 (NC9)7
Regioni1377 – 1428Triple-helical region 9 (COL9)Add BLAST52
Regioni1429 – 1441Nonhelical region 10 (NC10)Add BLAST13
Regioni1442 – 1459Triple-helical region 10 (COL10)Add BLAST18
Regioni1460 – 1774Nonhelical region 11 (NC11)Add BLAST315
Regioni1474 – 1519Non-collagenous domain 1 association domain1 PublicationAdd BLAST46
Regioni1520 – 1590Non-collagenous domain 1 hinge region1 PublicationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1351 – 1353Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multiplexin collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158212

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053241

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P39061

KEGG Orthology (KO)

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KOi
K06823

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQWTRFA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P39061

TreeFam database of animal gene trees

More...
TreeFami
TF315821

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07455 CRD_Collagen_XVIII, 1 hit
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039075 COL18A1
IPR008160 Collagen
IPR035523 Collagen_XVIII_Fz
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR010363 DUF959_COL18_N
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR45362 PTHR45362, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 5 hits
PF06121 DUF959, 1 hit
PF06482 Endostatin, 1 hit
PF01392 Fz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063 FRI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF63501 SSF63501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P39061-3) [UniParc]FASTAAdd to basket
Also known as: NC1-764

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPDPSRRLC LLLLLLLSCR LVPASADGNS LSPLNPLVWL WPPKTSDSLE
60 70 80 90 100
GPVSKPQNSS PVQSTENPTT HVVPQDGLTE QQTTPASSEL PPEEEEEEDQ
110 120 130 140 150
KAGQGGSPAT PAVPIPLVAP AASPDMKEEN VAGVGAKILN VAQGIRSFVQ
160 170 180 190 200
LWDEDSTIGH SAGTEVPDSS IPTVLPSPAE LSSAPQGSKT TLWLSSAIPS
210 220 230 240 250
SPDAQTTEAG TLAVPTQLPP FQSNLQAPLG RPSAPPDFPG RAFLSSSTDQ
260 270 280 290 300
GSSWGNQEPP RQPQHLEGKG FLPMTARSSQ QHRHSDVHSD IHGHVPLLPL
310 320 330 340 350
VTGPLVTASL SVHGLLSVPS SDPSGQLSQV AALPGFPGTW VSHVAPSSGT
360 370 380 390 400
GLSNDSALAG NGSLTSTSRC LPLPPTLTLC SRLGIGHFWL PNHLHHTDSV
410 420 430 440 450
EVEATVQAWG RFLHTNCHPF LAWFFCLLLA PSCGPGPPPP LPPCRQFCEA
460 470 480 490 500
LEDECWNYLA GDRLPVVCAS LPSQEDGYCV FIGPAAENVA EEVGLLQLLG
510 520 530 540 550
DPLPEKISQI DDPHVGPAYI FGPDSNSGQV AQYHFPKLFF RDFSLLFHVR
560 570 580 590 600
PATEAAGVLF AITDAAQVVV SLGVKLSEVR DGQQNISLLY TEPGASQTQT
610 620 630 640 650
GASFRLPAFV GQWTHFALSV DGGSVALYVD CEEFQRVPFA RASQGLELER
660 670 680 690 700
GAGLFVGQAG TADPDKFQGM ISELKVRKTP RVSPVHCLDE EDDDEDRASG
710 720 730 740 750
DFGSGFEESS KSHKEDTSLL PGLPQPPPVT SPPLAGGSTT EDPRTEETEE
760 770 780 790 800
DAAVDSIGAE TLPGTGSSGA WDEAIQNPGR GLIKGGMKGQ KGEPGAQGPP
810 820 830 840 850
GPAGPQGPAG PVVQSPNSQP VPGAQGPPGP QGPPGKDGTP GRDGEPGDPG
860 870 880 890 900
EDGRPGDTGP QGFPGTPGDV GPKGEKGDPG IGPRGPPGPP GPPGPSFRQD
910 920 930 940 950
KLTFIDMEGS GFSGDIESLR GPRGFPGPPG PPGVPGLPGE PGRFGINGSY
960 970 980 990 1000
APGPAGLPGV PGKEGPPGFP GPPGPPGPPG KEGPPGVAGQ KGSVGDVGIP
1010 1020 1030 1040 1050
GPKGSKGDLG PIGMPGKSGL AGSPGPVGPP GPPGPPGPPG PGFAAGFDDM
1060 1070 1080 1090 1100
EGSGIPLWTT ARSSDGLQGP PGSPGLKGDP GVAGLPGAKG EVGADGAQGI
1110 1120 1130 1140 1150
PGPPGREGAA GSPGPKGEKG MPGEKGNPGK DGVGRPGLPG PPGPPGPVIY
1160 1170 1180 1190 1200
VSSEDKAIVS TPGPEGKPGY AGFPGPAGPK GDLGSKGEQG LPGPKGEKGE
1210 1220 1230 1240 1250
PGTIFSPDGR ALGHPQKGAK GEPGFRGPPG PYGRPGHKGE IGFPGRPGRP
1260 1270 1280 1290 1300
GTNGLKGEKG EPGDASLGFS MRGLPGPPGP PGPPGPPGMP IYDSNAFVES
1310 1320 1330 1340 1350
GRPGLPGQQG VQGPSGPKGD KGEVGPPGPP GQFPIDLFHL EAEMKGDKGD
1360 1370 1380 1390 1400
RGDAGQKGER GEPGAPGGGF FSSSVPGPPG PPGYPGIPGP KGESIRGPPG
1410 1420 1430 1440 1450
PPGPQGPPGI GYEGRQGPPG PPGPPGPPSF PGPHRQTVSV PGPPGPPGPP
1460 1470 1480 1490 1500
GPPGAMGASA GQVRIWATYQ TMLDKIREVP EGWLIFVAER EELYVRVRNG
1510 1520 1530 1540 1550
FRKVLLEART ALPRGTGNEV AALQPPLVQL HEGSPYTRRE YSYSTARPWR
1560 1570 1580 1590 1600
ADDILANPPR LPDRQPYPGV PHHHSSYVHL PPARPTLSLA HTHQDFQPVL
1610 1620 1630 1640 1650
HLVALNTPLS GGMRGIRGAD FQCFQQARAV GLSGTFRAFL SSRLQDLYSI
1660 1670 1680 1690 1700
VRRADRGSVP IVNLKDEVLS PSWDSLFSGS QGQLQPGARI FSFDGRDVLR
1710 1720 1730 1740 1750
HPAWPQKSVW HGSDPSGRRL MESYCETWRT ETTGATGQAS SLLSGRLLEQ
1760 1770
KAASCHNSYI VLCIENSFMT SFSK
Note: Produced by alternative promoter usage.
Length:1,774
Mass (Da):182,172
Last modified:May 1, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA79BADD1E34407
GO
Isoform 2 (identifier: P39061-1) [UniParc]FASTAAdd to basket
Also known as: Long, NC1-517

The sequence of this isoform differs from the canonical sequence as follows:
     240-486: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:1,527
Mass (Da):155,950
Checksum:iE7AF043EC82D0326
GO
Isoform 3 (identifier: P39061-2) [UniParc]FASTAAdd to basket
Also known as: Short, NC1-301

The sequence of this isoform differs from the canonical sequence as follows:
     1-459: Missing.
     460-486: AGDRLPVVCASLPSQEDGYCVFIGPAA → MAPRWHLLDVLTSLVLLLVARVSWAEP

Note: Produced by alternative promoter usage.
Show »
Length:1,315
Mass (Da):134,204
Checksum:iB8215602ACE7AD1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPX1E9QPX1_MOUSE
Collagen alpha-1(XVIII) chain
Col18a1
1,774Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z556D3Z556_MOUSE
Collagen alpha-1(XVIII) chain
Col18a1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6N8A0A1W2P6N8_MOUSE
Collagen alpha-1(XVIII) chain
Col18a1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1046G → V in AAH66080 (PubMed:15489334).Curated1
Sequence conflicti1147P → L in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1194P → F in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1211A → R in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1347D → V in BAC27554 (PubMed:16141072).Curated1
Sequence conflicti1404P → R in AAA20657 (PubMed:8188673).Curated1
Sequence conflicti1404P → R in AAC52901 (PubMed:8838808).Curated1
Sequence conflicti1404P → R in AAC52902 (PubMed:8838808).Curated1
Sequence conflicti1404P → R in AAC52903 (PubMed:8838808).Curated1
Sequence conflicti1404P → R in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1513P → L in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1523L → F in AAA19787 (PubMed:8183893).Curated1
Sequence conflicti1684L → V in AAA19787 (PubMed:8183893).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0011571 – 459Missing in isoform 3. 5 PublicationsAdd BLAST459
Alternative sequenceiVSP_008303240 – 486Missing in isoform 2. CuratedAdd BLAST247
Alternative sequenceiVSP_001158460 – 486AGDRL…IGPAA → MAPRWHLLDVLTSLVLLLVA RVSWAEP in isoform 3. 5 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03714 mRNA Translation: AAA20657.1
U03715
, U34606, U34608, U34609, U34610, U34611, U34612, U34613, U03716, U03718 Genomic DNA Translation: AAC52901.1
U03715
, U34607, U34608, U34609, U34610, U34611, U34612, U34613, U03716, U03718 Genomic DNA Translation: AAC52902.1
U03715
, U03716, U03718, U34607, U34608, U34609, U34610, U34611, U34612, U34613 Genomic DNA Translation: AAC52903.1
AC055777 Genomic DNA No translation available.
AC159334 Genomic DNA No translation available.
BC064817 mRNA Translation: AAH64817.1
BC066080 mRNA Translation: AAH66080.1
L16898 mRNA Translation: AAA37434.1
AK031798 mRNA Translation: BAC27554.1
AK014292 mRNA Translation: BAB29249.1
U11636 mRNA Translation: AAC52178.1
U11637 mRNA Translation: AAC52179.1
L22545 mRNA Translation: AAA19787.1
D17546 mRNA Translation: BAA04483.1
AF257775 mRNA Translation: AAF69009.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23953.1 [P39061-2]
CCDS48604.1 [P39061-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56101
B56101

NCBI Reference Sequences

More...
RefSeqi
NP_001103461.1, NM_001109991.1 [P39061-1]
NP_034059.2, NM_009929.3 [P39061-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.4352

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000081654; ENSMUSP00000080358; ENSMUSG00000001435 [P39061-2]
ENSMUST00000105409; ENSMUSP00000101049; ENSMUSG00000001435 [P39061-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12822

UCSC genome browser

More...
UCSCi
uc007fvg.1 mouse [P39061-1]
uc007fvh.2 mouse [P39061-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03714 mRNA Translation: AAA20657.1
U03715
, U34606, U34608, U34609, U34610, U34611, U34612, U34613, U03716, U03718 Genomic DNA Translation: AAC52901.1
U03715
, U34607, U34608, U34609, U34610, U34611, U34612, U34613, U03716, U03718 Genomic DNA Translation: AAC52902.1
U03715
, U03716, U03718, U34607, U34608, U34609, U34610, U34611, U34612, U34613 Genomic DNA Translation: AAC52903.1
AC055777 Genomic DNA No translation available.
AC159334 Genomic DNA No translation available.
BC064817 mRNA Translation: AAH64817.1
BC066080 mRNA Translation: AAH66080.1
L16898 mRNA Translation: AAA37434.1
AK031798 mRNA Translation: BAC27554.1
AK014292 mRNA Translation: BAB29249.1
U11636 mRNA Translation: AAC52178.1
U11637 mRNA Translation: AAC52179.1
L22545 mRNA Translation: AAA19787.1
D17546 mRNA Translation: BAA04483.1
AF257775 mRNA Translation: AAF69009.1
CCDSiCCDS23953.1 [P39061-2]
CCDS48604.1 [P39061-1]
PIRiA56101
B56101
RefSeqiNP_001103461.1, NM_001109991.1 [P39061-1]
NP_034059.2, NM_009929.3 [P39061-2]
UniGeneiMm.4352

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DY0X-ray2.20A1587-1774[»]
1DY1X-ray2.20A1587-1774[»]
1KOEX-ray1.50A1597-1768[»]
ProteinModelPortaliP39061
SMRiP39061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198812, 1 interactor
ComplexPortaliCPX-2996 Collagen type XVIII trimer
STRINGi10090.ENSMUSP00000101049

PTM databases

iPTMnetiP39061
PhosphoSitePlusiP39061

Proteomic databases

PaxDbiP39061
PeptideAtlasiP39061
PRIDEiP39061

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081654; ENSMUSP00000080358; ENSMUSG00000001435 [P39061-2]
ENSMUST00000105409; ENSMUSP00000101049; ENSMUSG00000001435 [P39061-1]
GeneIDi12822
KEGGimmu:12822
UCSCiuc007fvg.1 mouse [P39061-1]
uc007fvh.2 mouse [P39061-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80781
MGIiMGI:88451 Col18a1

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
GeneTreeiENSGT00940000158212
HOVERGENiHBG053241
InParanoidiP39061
KOiK06823
OMAiGQWTRFA
PhylomeDBiP39061
TreeFamiTF315821

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000157 Laminin interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Col18a1 mouse
EvolutionaryTraceiP39061
PMAP-CutDBiP39061

Protein Ontology

More...
PROi
PR:P39061

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001435 Expressed in 322 organ(s), highest expression level in aorta
CleanExiMM_COL18A1
ExpressionAtlasiP39061 baseline and differential
GenevisibleiP39061 MM

Family and domain databases

CDDicd07455 CRD_Collagen_XVIII, 1 hit
cd00247 Endostatin-like, 1 hit
Gene3Di1.10.2000.10, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039075 COL18A1
IPR008160 Collagen
IPR035523 Collagen_XVIII_Fz
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR010363 DUF959_COL18_N
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001791 Laminin_G
PANTHERiPTHR45362 PTHR45362, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF06121 DUF959, 1 hit
PF06482 Endostatin, 1 hit
PF01392 Fz, 1 hit
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOIA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39061
Secondary accession number(s): Q60672
, Q61434, Q61437, Q62001, Q62002, Q6NZK9, Q6P1Y4, Q8CCZ8, Q9CRT2, Q9JK63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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