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Protein

Collagen alpha-1(XV) chain

Gene

COL15A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.1 Publication
Restin potently inhibits angiogenesis.By similarity

Caution

The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Cell adhesion, Differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8948216 Collagen chain trimerization

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P39059

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XV) chain
Cleaved into the following 4 chains:
Alternative name(s):
Endostatin-XV
Related to endostatin
Restin-I
Alternative name(s):
Restin-II
Alternative name(s):
Restin-III
Alternative name(s):
Restin-IV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL15A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204291.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2192 COL15A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120325 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P39059

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1306

Open Targets

More...
OpenTargetsi
ENSG00000204291

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26708

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68839886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000578828 – 1388Collagen alpha-1(XV) chainAdd BLAST1361
ChainiPRO_00000057891198 – 1386RestinAdd BLAST189
ChainiPRO_00004230141207 – 1386Restin-2Add BLAST180
ChainiPRO_00004230151213 – 1386Restin-3Add BLAST174
ChainiPRO_00004230161221 – 1386Restin-4Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi265O-linked (GalNAc...) threonine1 Publication1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1046N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1237 ↔ 13771 Publication
Disulfide bondi1339 ↔ 13691 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39059

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39059

PeptideAtlas

More...
PeptideAtlasi
P39059

PRoteomics IDEntifications database

More...
PRIDEi
P39059

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55310

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
727

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P39059

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P39059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204291 Expressed in 196 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_COL15A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P39059 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P39059 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017913
HPA017915

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimer; disulfide-linked.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107702, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1756 Collagen type XV trimer

Protein interaction database and analysis system

More...
IntActi
P39059, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364140

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P39059

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P39059

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 249Laminin G-likeAdd BLAST184
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati358 – 4081Add BLAST51
Repeati409 – 4592Add BLAST51
Repeati460 – 5093Add BLAST50
Repeati510 – 5554Add BLAST46
Domaini619 – 680Collagen-like 1Add BLAST62
Domaini681 – 731Collagen-like 2Add BLAST51
Domaini823 – 865Collagen-like 3Add BLAST43
Domaini879 – 927Collagen-like 4Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 555Nonhelical region 1 (NC1)Add BLAST327
Regioni358 – 5554 X tandem repeatsAdd BLAST198
Regioni556 – 573Triple-helical region 1 (COL1)Add BLAST18
Regioni574 – 618Nonhelical region 2 (NC2)Add BLAST45
Regioni619 – 732Triple-helical region 2 (COL2)Add BLAST114
Regioni733 – 763Nonhelical region 3 (NC3)Add BLAST31
Regioni764 – 798Triple-helical region 3 (COL3)Add BLAST35
Regioni799 – 822Nonhelical region 4 (NC4)Add BLAST24
Regioni823 – 867Triple-helical region 4 (COL4)Add BLAST45
Regioni868 – 878Nonhelical region 5 (NC5)Add BLAST11
Regioni879 – 949Triple-helical region 5 (COL5)Add BLAST71
Regioni950 – 983Nonhelical region 6 (NC6)Add BLAST34
Regioni984 – 1013Triple-helical region 6 (COL6)Add BLAST30
Regioni1014 – 1027Nonhelical region 7 (NC7)Add BLAST14
Regioni1028 – 1045Triple-helical region 7 (COL7)Add BLAST18
Regioni1046 – 1052Nonhelical region 8 (NC8)7
Regioni1053 – 1107Triple-helical region 8 (COL8)Add BLAST55
Regioni1108 – 1117Nonhelical region 9 (NC9)10
Regioni1118 – 1132Triple-helical region 9 (COL9)Add BLAST15
Regioni1133 – 1388Nonhelical region 10 (NC10)Add BLAST256

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multiplexin collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158302

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231591

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080337

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39059

KEGG Orthology (KO)

More...
KOi
K08135

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHSRIPF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01N2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P39059

TreeFam database of animal gene trees

More...
TreeFami
TF315821

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039070 COL15A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR44929 PTHR44929, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 4 hits
PF06482 Endostatin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P39059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRRNNGQC WCLLMLLSVS TPLPAVTQTR GATETASQGH LDLTQLIGVP
60 70 80 90 100
LPSSVSFVTG YGGFPAYSFG PGANVGRPAR TLIPSTFFRD FAISVVVKPS
110 120 130 140 150
STRGGVLFAI TDAFQKVIYL GLRLSGVEDG HQRIILYYTE PGSHVSQEAA
160 170 180 190 200
AFSVPVMTHR WNRFAMIVQG EEVTLLVNCE EHSRIPFQRS SQALAFESSA
210 220 230 240 250
GIFMGNAGAT GLERFTGSLQ QLTVHPDPRT PEELCDPEES SASGETSGLQ
260 270 280 290 300
EADGVAEILE AVTYTQASPK EAKVEPINTP PTPSSPFEDM ELSGEPVPEG
310 320 330 340 350
TLETTNMSII QHSSPKQGSG EILNDTLEGV HSVDGDPITD SGSGAGAFLD
360 370 380 390 400
IAEEKNLAAT AAGLAEVPIS TAGEAEASSV PTGGPTLSMS TENPEEGVTP
410 420 430 440 450
GPDNEERLAA TAAGEAEALA SMPGEVEASG VAPGELDLSM SAQSLGEEAT
460 470 480 490 500
VGPSSEDSLT TAAAATEVSL STFEDEEASG VPTDGLAPLT ATMAPERAVT
510 520 530 540 550
SGPGDEEDLA AATTEEPLIT AGGEESGSPP PDGPPLPLPT VAPERWITPA
560 570 580 590 600
QREHVGMKGQ AGPKGEKGDA GEELPGPPEP SGPVGPTAGA EAEGSGLGWG
610 620 630 640 650
SDVGSGSGDL VGSEQLLRGP PGPPGPPGLP GIPGKPGTDV FMGPPGSPGE
660 670 680 690 700
DGPAGEPGPP GPEGQPGVDG ATGLPGMKGE KGARGPNGSV GEKGDPGNRG
710 720 730 740 750
LPGPPGKKGQ AGPPGVMGPP GPPGPPGPPG PGCTMGLGFE DTEGSGSTQL
760 770 780 790 800
LNEPKLSRPT AAIGLKGEKG DRGPKGERGM DGASIVGPPG PRGPPGHIKV
810 820 830 840 850
LSNSLINITH GFMNFSDIPE LVGPPGPDGL PGLPGFPGPR GPKGDTGLPG
860 870 880 890 900
FPGLKGEQGE KGEPGAILTE DIPLERLMGK KGEPGMHGAP GPMGPKGPPG
910 920 930 940 950
HKGEFGLPGR PGRPGLNGLK GTKGDPGVIM QGPPGLPGPP GPPGPPGAVI
960 970 980 990 1000
NIKGAIFPIP VRPHCKMPVD TAHPGSPELI TFHGVKGEKG SWGLPGSKGE
1010 1020 1030 1040 1050
KGDQGAQGPP GPPLDLAYLR HFLNNLKGEN GDKGFKGEKG EKGDINGSFL
1060 1070 1080 1090 1100
MSGPPGLPGN PGPAGQKGET VVGPQGPPGA PGLPGPPGFG RPGDPGPPGP
1110 1120 1130 1140 1150
PGPPGPPAIL GAAVALPGPP GPPGQPGLPG SRNLVTAFSN MDDMLQKAHL
1160 1170 1180 1190 1200
VIEGTFIYLR DSTEFFIRVR DGWKKLQLGE LIPIPADSPP PPALSSNPHQ
1210 1220 1230 1240 1250
LLPPPNPISS ANYEKPALHL AALNMPFSGD IRADFQCFKQ ARAAGLLSTY
1260 1270 1280 1290 1300
RAFLSSHLQD LSTIVRKAER YSLPIVNLKG QVLFNNWDSI FSGHGGQFNM
1310 1320 1330 1340 1350
HIPIYSFDGR DIMTDPSWPQ KVIWHGSSPH GVRLVDNYCE AWRTADTAVT
1360 1370 1380
GLASPLSTGK ILDQKAYSCA NRLIVLCIEN SFMTDARK
Length:1,388
Mass (Da):141,720
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF54DDCC136C3745
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0K0A0A087X0K0_HUMAN
Collagen alpha-1(XV) chain
COL15A1
1,374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10C → S in BAA04762 (PubMed:8307960).Curated1
Sequence conflicti49V → D in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti94 – 95SV → RA in AAA58429 (PubMed:8106446).Curated2
Sequence conflicti94 – 95SV → RA in BAA04762 (PubMed:8307960).Curated2
Sequence conflicti150A → P in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti409A → R in AAA58429 (PubMed:8106446).Curated1
Sequence conflicti409A → R in AAC78500 (PubMed:9651385).Curated1
Sequence conflicti1134L → LLGELIPIPADSPPPPALSS N in AAC78500 (PubMed:9651385).Curated1
Sequence conflicti1178 – 1197Missing in AAC78500 (PubMed:9651385).CuratedAdd BLAST20
Sequence conflicti1227F → V in AAC78500 (PubMed:9651385).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033787163R → H. Corresponds to variant dbSNP:rs2075662Ensembl.1
Natural variantiVAR_033788204M → V1 PublicationCorresponds to variant dbSNP:rs2075663Ensembl.1
Natural variantiVAR_033789391T → M. Corresponds to variant dbSNP:rs10988532Ensembl.1
Natural variantiVAR_033790442A → T. Corresponds to variant dbSNP:rs16918128Ensembl.1
Natural variantiVAR_033791446G → R. Corresponds to variant dbSNP:rs35934703Ensembl.1
Natural variantiVAR_048776504G → V. Corresponds to variant dbSNP:rs2297603Ensembl.1
Natural variantiVAR_033792506E → D. Corresponds to variant dbSNP:rs35250850Ensembl.1
Natural variantiVAR_033793531P → R. Corresponds to variant dbSNP:rs35529307Ensembl.1
Natural variantiVAR_061114705P → L. Corresponds to variant dbSNP:rs41308900Ensembl.1
Natural variantiVAR_033794989K → R. Corresponds to variant dbSNP:rs35642150Ensembl.1
Natural variantiVAR_0337951001K → R. Corresponds to variant dbSNP:rs35544077Ensembl.1
Natural variantiVAR_0337961332V → I. Corresponds to variant dbSNP:rs10519Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L25286 mRNA Translation: AAA58429.1
L25280
, L25281, L25282, L25283, L25284, L25285, AF052956, AF052957, AF052958, AF052959, AF052960, AF052961, AF052962, AF052963, AF052964, AF052965, AF052966, AF052967, AF052968, AF052969, AF052970, AF052971, AF052972, AF052973, AF052974, AF052975 Genomic DNA Translation: AAC78500.1
AL136084 Genomic DNA No translation available.
AL354923 Genomic DNA No translation available.
D21230 mRNA Translation: BAA04762.1
L01697 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35081.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A53317

NCBI Reference Sequences

More...
RefSeqi
NP_001846.3, NM_001855.4
XP_011516516.1, XM_011518214.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.409034

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375001; ENSP00000364140; ENSG00000204291

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1306

UCSC genome browser

More...
UCSCi
uc004azb.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25286 mRNA Translation: AAA58429.1
L25280
, L25281, L25282, L25283, L25284, L25285, AF052956, AF052957, AF052958, AF052959, AF052960, AF052961, AF052962, AF052963, AF052964, AF052965, AF052966, AF052967, AF052968, AF052969, AF052970, AF052971, AF052972, AF052973, AF052974, AF052975 Genomic DNA Translation: AAC78500.1
AL136084 Genomic DNA No translation available.
AL354923 Genomic DNA No translation available.
D21230 mRNA Translation: BAA04762.1
L01697 mRNA No translation available.
CCDSiCCDS35081.1
PIRiA53317
RefSeqiNP_001846.3, NM_001855.4
XP_011516516.1, XM_011518214.2
UniGeneiHs.409034

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N3FX-ray2.00A/B1133-1186[»]
ProteinModelPortaliP39059
SMRiP39059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107702, 1 interactor
ComplexPortaliCPX-1756 Collagen type XV trimer
IntActiP39059, 4 interactors
STRINGi9606.ENSP00000364140

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

GlyConnecti727
iPTMnetiP39059
PhosphoSitePlusiP39059
UniCarbKBiP39059

Polymorphism and mutation databases

DMDMi68839886

Proteomic databases

MaxQBiP39059
PaxDbiP39059
PeptideAtlasiP39059
PRIDEiP39059
ProteomicsDBi55310

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1306
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375001; ENSP00000364140; ENSG00000204291
GeneIDi1306
KEGGihsa:1306
UCSCiuc004azb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1306
DisGeNETi1306
EuPathDBiHostDB:ENSG00000204291.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COL15A1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008227
HGNCiHGNC:2192 COL15A1
HPAiHPA017913
HPA017915
MIMi120325 gene
neXtProtiNX_P39059
OpenTargetsiENSG00000204291
PharmGKBiPA26708

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
GeneTreeiENSGT00940000158302
HOGENOMiHOG000231591
HOVERGENiHBG080337
InParanoidiP39059
KOiK08135
OMAiEHSRIPF
OrthoDBiEOG091G01N2
PhylomeDBiP39059
TreeFamiTF315821

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-8948216 Collagen chain trimerization
SIGNORiP39059

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL15A1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Collagen,_type_XV,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1306

Protein Ontology

More...
PROi
PR:P39059

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204291 Expressed in 196 organ(s), highest expression level in placenta
CleanExiHS_COL15A1
ExpressionAtlasiP39059 baseline and differential
GenevisibleiP39059 HS

Family and domain databases

CDDicd00247 Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039070 COL15A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G
PANTHERiPTHR44929 PTHR44929, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 4 hits
PF06482 Endostatin, 2 hits
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOFA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39059
Secondary accession number(s): Q5T6J4, Q9UDC5, Q9Y4W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 5, 2005
Last modified: December 5, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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