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Protein

Dynamin-2

Gene

Dnm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:18923138). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (PubMed:18425118).By similarity2 Publications

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 46GTPBy similarity9
Nucleotide bindingi205 – 211GTPBy similarity7
Nucleotide bindingi236 – 239GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis, Phagocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5 3474
ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-203641 NOSTRIN mediated eNOS trafficking
R-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-437239 Recycling pathway of L1
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-2 (EC:3.6.5.5)
Alternative name(s):
Dynamin UDNM
Gene namesi
Name:Dnm2
Synonyms:Dyn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109547 Dnm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Exhibits growth and cytokinesis defects.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44K → A: Apoptotic cell corpse-containing phagosomes fail to mature into acidic phagosomes. Loss of PIK3C3 and RAB5A recruitment to phagosomes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065711 – 870Dynamin-2Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphotyrosineBy similarity1
Modified residuei299N6-acetyllysineCombined sources1
Modified residuei597PhosphotyrosineBy similarity1
Modified residuei598N6-acetyllysineBy similarity1
Modified residuei755PhosphothreonineBy similarity1
Modified residuei764Phosphoserine; by CDK1By similarity1

Post-translational modificationi

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP39054
PaxDbiP39054
PeptideAtlasiP39054
PRIDEiP39054

2D gel databases

REPRODUCTION-2DPAGEiIPI00131445

PTM databases

iPTMnetiP39054
PhosphoSitePlusiP39054

Expressioni

Tissue specificityi

Expressed in most tissues during embryonic development, including the peripheral nervous system although no expression is evident in skeletal muscle or heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000033335 Expressed in 273 organ(s), highest expression level in muscle tissue
CleanExiMM_DNM2
ExpressionAtlasiP39054 baseline and differential
GenevisibleiP39054 MM

Interactioni

Subunit structurei

Interacts with SHANK1, SHANK2 and NOSTRIN. Interacts with SNX9. Interacts with SNX33 (via SH3 domain). Interacts with MYO1E (via SH3 domain). Interacts with CTTN and ACTN1 (By similarity). Interacts with MYOF and SH3BP4 (PubMed:17702744, PubMed:16325581). Interacts with PSTPIP1. Interacts with CTNND2 (By similarity). May interact with PIK3C3 (PubMed:18425118). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (PubMed:18425118).By similarity1 Publication2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199258, 10 interactors
IntActiP39054, 20 interactors
MINTiP39054
STRINGi10090.ENSMUSP00000133564

Structurei

3D structure databases

ProteinModelPortaliP39054
SMRiP39054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini519 – 625PHPROSITE-ProRule annotationAdd BLAST107
Domaini653 – 744GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi747 – 866Pro-richAdd BLAST120

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000161069
HOVERGENiHBG107833
InParanoidiP39054
KOiK01528
PhylomeDBiP39054
TreeFamiTF300362

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027188 DNM2
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF23 PTHR11566:SF23, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P39054-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEY AEFLHCKSKK FTDFDEVRQE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA
260 270 280 290 300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPTLRSKL
310 320 330 340 350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT
410 420 430 440 450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELISTVR QCTSKLSSYP
460 470 480 490 500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL
560 570 580 590 600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL
610 620 630 640 650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE
660 670 680 690 700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY
710 720 730 740 750
SSADQSSLME ESAEQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP
760 770 780 790 800
PVDDTWLQNT SGHSPTPQRR PVSSVHPPGR PPAVRGPTPG PPLIPMPVGA
810 820 830 840 850
TSSFSAPPIP SRPGPQSVFA NNDPFSAPPQ IPSRPARIPP GIPPGVPSRR
860 870
APAAPSRPTI IRPAEPSLLD
Length:870
Mass (Da):98,145
Last modified:July 26, 2002 - v2
Checksum:iE80864AF94B8F778
GO
Isoform 2 (identifier: P39054-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.

Show »
Length:866
Mass (Da):97,733
Checksum:iCA0BEB6FA5E5028D
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9G4G3X9G4_MOUSE
Dynamin-2
Dnm2
870Annotation score:
Q3TCR7Q3TCR7_MOUSE
Dynamin-2
Dnm2
869Annotation score:
Q3T9X3Q3T9X3_MOUSE
Dynamin-2
Dnm2
860Annotation score:
F8WIV5F8WIV5_MOUSE
Dynamin-2
Dnm2
870Annotation score:
G3UZZ3G3UZZ3_MOUSE
Dynamin-2
Dnm2
807Annotation score:
G3UXX2G3UXX2_MOUSE
Dynamin-2
Dnm2
248Annotation score:
G3UY64G3UY64_MOUSE
Dynamin-2
Dnm2
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297 – 298RS → HG in AAA40523 (PubMed:9143510).Curated2
Sequence conflicti848 – 870SRRAP…PSLLD → RRPPPLAPARPFF in BAB23745 (PubMed:16141072).CuratedAdd BLAST23

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001326516 – 519Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31398 mRNA Translation: AAA40523.1
AK005012 mRNA Translation: BAB23745.1
CCDSiCCDS57657.1 [P39054-1]
CCDS57659.1 [P39054-2]
RefSeqiNP_001240822.1, NM_001253893.1 [P39054-1]
NP_001240823.1, NM_001253894.1
NP_031897.2, NM_007871.2 [P39054-2]
UniGeneiMm.433257

Genome annotation databases

EnsembliENSMUST00000091087; ENSMUSP00000088616; ENSMUSG00000033335 [P39054-2]
ENSMUST00000172482; ENSMUSP00000133564; ENSMUSG00000033335 [P39054-1]
GeneIDi13430
KEGGimmu:13430
UCSCiuc009olk.2 mouse [P39054-2]
uc029wxt.1 mouse [P39054-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31398 mRNA Translation: AAA40523.1
AK005012 mRNA Translation: BAB23745.1
CCDSiCCDS57657.1 [P39054-1]
CCDS57659.1 [P39054-2]
RefSeqiNP_001240822.1, NM_001253893.1 [P39054-1]
NP_001240823.1, NM_001253894.1
NP_031897.2, NM_007871.2 [P39054-2]
UniGeneiMm.433257

3D structure databases

ProteinModelPortaliP39054
SMRiP39054
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199258, 10 interactors
IntActiP39054, 20 interactors
MINTiP39054
STRINGi10090.ENSMUSP00000133564

PTM databases

iPTMnetiP39054
PhosphoSitePlusiP39054

2D gel databases

REPRODUCTION-2DPAGEiIPI00131445

Proteomic databases

MaxQBiP39054
PaxDbiP39054
PeptideAtlasiP39054
PRIDEiP39054

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091087; ENSMUSP00000088616; ENSMUSG00000033335 [P39054-2]
ENSMUST00000172482; ENSMUSP00000133564; ENSMUSG00000033335 [P39054-1]
GeneIDi13430
KEGGimmu:13430
UCSCiuc009olk.2 mouse [P39054-2]
uc029wxt.1 mouse [P39054-1]

Organism-specific databases

CTDi1785
MGIiMGI:109547 Dnm2

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000161069
HOVERGENiHBG107833
InParanoidiP39054
KOiK01528
PhylomeDBiP39054
TreeFamiTF300362

Enzyme and pathway databases

BRENDAi3.6.5.5 3474
ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-203641 NOSTRIN mediated eNOS trafficking
R-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-437239 Recycling pathway of L1
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiDnm2 mouse
PROiPR:P39054
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033335 Expressed in 273 organ(s), highest expression level in muscle tissue
CleanExiMM_DNM2
ExpressionAtlasiP39054 baseline and differential
GenevisibleiP39054 MM

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027188 DNM2
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF23 PTHR11566:SF23, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYN2_MOUSE
AccessioniPrimary (citable) accession number: P39054
Secondary accession number(s): Q9DBE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 26, 2002
Last modified: October 10, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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