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UniProtKB - P39053 (DYN1_MOUSE)

Entry version 207 (23 Feb 2022)
Sequence version 2 (20 Jun 2003)
Previous versions | rss
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Protein

Dynamin-1

Gene

Dnm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi136 – 140GTPBy similarity5
Nucleotide bindingi205 – 208GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.5.5, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-166016, Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873, Gap junction degradation
R-MMU-196025, Formation of annular gap junctions
R-MMU-2132295, MHC class II antigen presentation
R-MMU-437239, Recycling pathway of L1
R-MMU-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnm1
Synonyms:Dnm, Kiaa4093
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107384, Dnm1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000026825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065641 – 867Dynamin-1Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80PhosphotyrosineCombined sources1
Modified residuei1253'-nitrotyrosine; alternateCombined sources1
Modified residuei125Phosphotyrosine; alternateCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei354PhosphotyrosineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei774PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1
Modified residuei796Omega-N-methylarginineCombined sources1
Modified residuei822PhosphoserineBy similarity1
Isoform 6 (identifier: P39053-6)
Modified residuei847PhosphoserineCombined sources1
Isoform 4 (identifier: P39053-4)
Modified residuei851PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR.1 Publication

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P39053

MaxQB - The MaxQuant DataBase

More...MaxQBi		P39053

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39053

PeptideAtlas

More...PeptideAtlasi		P39053

PRoteomics IDEntifications database

More...PRIDEi		P39053

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		277649 [P39053-1]
277650 [P39053-3]
277651 [P39053-4]
277652 [P39053-5]
277653 [P39053-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39053

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P39053

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P39053

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026825, Expressed in prefrontal cortex and 279 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P39053, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P39053, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity).

Interacts with SNX9 (By similarity).

Interacts with PHOCN.

Interacts with MYO1E (via SH3 domain).

Interacts with SNX33 (via SH3 domain) (By similarity).

Interacts with CAV1 and SH3GLB1.

Interacts with PACSIN1, PACSIN2 and PACSIN3.

Interacts with UNC119; leading to a decrease of DNM1 GTPase activity.

Interacts with DIAPH1 (By similarity).

Interacts with AMPH, BIN1 AND SYNJ1 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199257, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P39053

Protein interaction database and analysis system

More...IntActi		P39053, 36 interactors

Molecular INTeraction database

More...MINTi		P39053

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000088618

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P39053, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P39053

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39053

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini515 – 625PHPROSITE-ProRule annotationAdd BLAST111
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4
Regioni767 – 867DisorderedSequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi767 – 781Polar residuesSequence analysisAdd BLAST15
Compositional biasi782 – 840Pro residuesSequence analysisAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0446, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155214

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39053

Identification of Orthologs from Complete Genome Data

More...OMAi		ENISWFK

Database of Orthologous Groups

More...OrthoDBi		264244at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39053

TreeFam database of animal gene trees

More...TreeFami		TF300362

Family and domain databases

Conserved Domains Database

More...CDDi		cd08771, DLP_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027741, DNM1
IPR022812, Dynamin
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR045063, Dynamin_N
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00195, DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P39053-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP 
       160        170        180        190        200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA 
       260        270        280        290        300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 
       310        320        330        340        350
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ 
       360        370        380        390        400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT 
       410        420        430        440        450
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP 
       460        470        480        490        500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ 
       510        520        530        540        550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL 
       560        570        580        590        600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY 
       610        620        630        640        650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS 
       660        670        680        690        700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE 
       710        720        730        740        750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV 
       760        770        780        790        800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP 
       810        820        830        840        850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSLGAWR 
       860 
LNSPQGKHEN RAGKARL
Length:867
Mass (Da):97,803
Last modified:June 20, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF48EC3DF5F39A08B
GO
Isoform 3 (identifier: P39053-3) [UniParc]FASTAAdd to basket
Also known as: BraDnm8

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 4 (identifier: P39053-4) [UniParc]FASTAAdd to basket
Also known as: BraDnm2

The sequence of this isoform differs from the canonical sequence as follows:
     846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 5 (identifier: P39053-5) [UniParc]FASTAAdd to basket
Also known as: BreDnm15

The sequence of this isoform differs from the canonical sequence as follows:
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 6 (identifier: P39053-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

Show »
Length:864
Mass (Da):97,284
Checksum:i12CA402BCCCF2936
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUN4A0A0J9YUN4_MOUSE
Dynamin GTPase
Dnm1
864Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUE9A0A0J9YUE9_MOUSE
Dynamin GTPase
Dnm1
835Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RRH9F6RRH9_MOUSE
Dynamin-1
Dnm1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TH70F6TH70_MOUSE
Dynamin-1
Dnm1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W8Z8F6W8Z8_MOUSE
Dynamin-1
Dnm1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUS0A0A0J9YUS0_MOUSE
Dynamin-1
Dnm1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH60D6RH60_MOUSE
Dynamin-1
Dnm1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA37324 differs from that shown. Reason: Frameshift.Curated
The sequence BAD90284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135V → A in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti450P → R in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti531I → S in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti573R → H in BAE25726 (PubMed:16141072).Curated1
Sequence conflicti600Y → N in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti703A → V in AAH58623 (PubMed:15489334).Curated1
Sequence conflicti722A → R in AAA37319 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37323 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37324 (PubMed:9143510).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007643407 – 444MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_007644516 – 519Missing in isoform 6. 2 Publications4
Alternative sequenceiVSP_007645845 – 867SLGAW…GKARL → RITISDP in isoform 3 and isoform 5. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_007647846 – 867LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_024845846 – 867LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L29457 mRNA Translation: AAA37319.1
L31395 mRNA Translation: AAA37318.1
L31396 mRNA Translation: AAA37323.1
L31397 mRNA Translation: AAA37324.1 Frameshift.
AK011651 mRNA Translation: BAB27759.1
AK144142 mRNA Translation: BAE25726.1
AK220483 mRNA Translation: BAD90284.1 Different initiation.
AL808027 Genomic DNA No translation available.
BC034679 mRNA Translation: AAH34679.1
BC058623 mRNA Translation: AAH58623.1
AF170568 Genomic DNA Translation: AAF24220.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38102.1 [P39053-6]
CCDS79772.1 [P39053-3]

NCBI Reference Sequences

More...RefSeqi		NP_001288666.1, NM_001301737.1 [P39053-3]
NP_034195.2, NM_010065.3 [P39053-6]
XP_006497718.2, XM_006497655.2 [P39053-4]
XP_006497721.2, XM_006497658.3 [P39053-3]
XP_006497722.2, XM_006497659.3 [P39053-3]
XP_006497723.2, XM_006497660.2 [P39053-3]
XP_006497724.2, XM_006497661.2 [P39053-5]
XP_017170817.1, XM_017315328.1 [P39053-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825 [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825 [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825 [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825 [P39053-1]
ENSMUST00000202578; ENSMUSP00000143955; ENSMUSG00000026825 [P39053-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13429

UCSC genome browser

More...UCSCi		uc008jfc.2, mouse [P39053-6]
uc008jfd.3, mouse [P39053-3]
uc029twn.1, mouse [P39053-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29457 mRNA Translation: AAA37319.1
L31395 mRNA Translation: AAA37318.1
L31396 mRNA Translation: AAA37323.1
L31397 mRNA Translation: AAA37324.1 Frameshift.
AK011651 mRNA Translation: BAB27759.1
AK144142 mRNA Translation: BAE25726.1
AK220483 mRNA Translation: BAD90284.1 Different initiation.
AL808027 Genomic DNA No translation available.
BC034679 mRNA Translation: AAH34679.1
BC058623 mRNA Translation: AAH58623.1
AF170568 Genomic DNA Translation: AAF24220.1
CCDSiCCDS38102.1 [P39053-6]
CCDS79772.1 [P39053-3]
RefSeqiNP_001288666.1, NM_001301737.1 [P39053-3]
NP_034195.2, NM_010065.3 [P39053-6]
XP_006497718.2, XM_006497655.2 [P39053-4]
XP_006497721.2, XM_006497658.3 [P39053-3]
XP_006497722.2, XM_006497659.3 [P39053-3]
XP_006497723.2, XM_006497660.2 [P39053-3]
XP_006497724.2, XM_006497661.2 [P39053-5]
XP_017170817.1, XM_017315328.1 [P39053-5]

3D structure databases

BMRBiP39053
SMRiP39053
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199257, 54 interactors
CORUMiP39053
IntActiP39053, 36 interactors
MINTiP39053
STRINGi10090.ENSMUSP00000088618

Chemistry databases

ChEMBLiCHEMBL4523222

PTM databases

iPTMnetiP39053
PhosphoSitePlusiP39053
SwissPalmiP39053

Proteomic databases

jPOSTiP39053
MaxQBiP39053
PaxDbiP39053
PeptideAtlasiP39053
PRIDEiP39053
ProteomicsDBi277649 [P39053-1]
277650 [P39053-3]
277651 [P39053-4]
277652 [P39053-5]
277653 [P39053-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3472, 686 antibodies from 46 providers

The DNASU plasmid repository

More...DNASUi		13429

Genome annotation databases

EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825 [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825 [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825 [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825 [P39053-1]
ENSMUST00000202578; ENSMUSP00000143955; ENSMUSG00000026825 [P39053-3]
GeneIDi13429
KEGGimmu:13429
UCSCiuc008jfc.2, mouse [P39053-6]
uc008jfd.3, mouse [P39053-3]
uc029twn.1, mouse [P39053-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1759
MGIiMGI:107384, Dnm1
VEuPathDBiHostDB:ENSMUSG00000026825

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0446, Eukaryota
GeneTreeiENSGT00940000155214
InParanoidiP39053
OMAiENISWFK
OrthoDBi264244at2759
PhylomeDBiP39053
TreeFamiTF300362

Enzyme and pathway databases

BRENDAi3.6.5.5, 3474
ReactomeiR-MMU-166016, Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873, Gap junction degradation
R-MMU-196025, Formation of annular gap junctions
R-MMU-2132295, MHC class II antigen presentation
R-MMU-437239, Recycling pathway of L1
R-MMU-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		13429, 1 hit in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Dnm1, mouse

Protein Ontology

More...PROi		PR:P39053
RNActiP39053, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026825, Expressed in prefrontal cortex and 279 other tissues
ExpressionAtlasiP39053, baseline and differential
GenevisibleiP39053, MM

Family and domain databases

CDDicd08771, DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027741, DNM1
IPR022812, Dynamin
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR045063, Dynamin_N
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00195, DYNAMIN
SMARTiView protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYN1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39053
Secondary accession number(s): A2AN50
, A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 20, 2003
Last modified: February 23, 2022
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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