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Protein

Dynamin-1

Gene

Dnm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi136 – 140GTPBy similarity5
Nucleotide bindingi205 – 208GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • clathrin-dependent endocytosis Source: InterPro
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • endocytosis Source: MGI
  • endosome organization Source: MGI
  • G-protein coupled receptor internalization Source: MGI
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • positive regulation of synaptic vesicle endocytosis Source: MGI
  • positive regulation of synaptic vesicle recycling Source: MGI
  • protein tetramerization Source: MGI
  • receptor internalization Source: MGI
  • receptor-mediated endocytosis Source: MGI
  • regulation of synaptic vesicle endocytosis Source: MGI
  • response to amyloid-beta Source: Ensembl
  • sensory perception of sound Source: MGI
  • synaptic transmission, GABAergic Source: MGI
  • synaptic vesicle budding from presynaptic endocytic zone membrane Source: SynGO
  • toxin transport Source: MGI

Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2132295 MHC class II antigen presentation
R-MMU-437239 Recycling pathway of L1
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Gene namesi
Name:Dnm1
Synonyms:Dnm, Kiaa4093
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107384 Dnm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065641 – 867Dynamin-1Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphotyrosineCombined sources1
Modified residuei125Nitrated tyrosine; alternateCombined sources1
Modified residuei125Phosphotyrosine; alternateCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei354PhosphotyrosineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei774PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1
Modified residuei796Omega-N-methylarginineCombined sources1
Modified residuei822PhosphoserineBy similarity1
Isoform 6 (identifier: P39053-6)
Modified residuei847PhosphoserineCombined sources1
Isoform 4 (identifier: P39053-4)
Modified residuei851PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to EGF stimulation in cells expressing truncated EGFR.1 Publication

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

MaxQBiP39053
PaxDbiP39053
PeptideAtlasiP39053
PRIDEiP39053

PTM databases

iPTMnetiP39053
PhosphoSitePlusiP39053
SwissPalmiP39053

Expressioni

Gene expression databases

BgeeiENSMUSG00000026825
CleanExiMM_DNM1
ExpressionAtlasiP39053 baseline and differential
GenevisibleiP39053 MM

Interactioni

Subunit structurei

Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with SNX9 (By similarity). Interacts with PHOCN. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with CAV1 and SH3GLB1. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with UNC119; leading to a decrease of DNM1 GTPase activity. Interacts with DIAPH1 (By similarity).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199257, 34 interactors
CORUMiP39053
IntActiP39053, 39 interactors
MINTiP39053
STRINGi10090.ENSMUSP00000088618

Structurei

3D structure databases

ProteinModelPortaliP39053
SMRiP39053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini515 – 625PHPROSITE-ProRule annotationAdd BLAST111
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOVERGENiHBG107833
InParanoidiP39053
KOiK01528
OMAiKIKEPCL
OrthoDBiEOG091G0EIQ
PhylomeDBiP39053
TreeFamiTF300362

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027741 DNM1
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF32 PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P39053-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
160 170 180 190 200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP
460 470 480 490 500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
610 620 630 640 650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
760 770 780 790 800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
810 820 830 840 850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSLGAWR
860
LNSPQGKHEN RAGKARL
Length:867
Mass (Da):97,803
Last modified:June 20, 2003 - v2
Checksum:iF48EC3DF5F39A08B
GO
Isoform 3 (identifier: P39053-3) [UniParc]FASTAAdd to basket
Also known as: BraDnm8

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: MAFETIVKKQ...LISTVRQCTK → LAFEATVKKQ...LTSTIRKCSE
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 4 (identifier: P39053-4) [UniParc]FASTAAdd to basket
Also known as: BraDnm2

The sequence of this isoform differs from the canonical sequence as follows:
     846-867: LGAWRLNSPQGKHENRAGKARL → RSGQASPSRPESPRPPFDL

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 5 (identifier: P39053-5) [UniParc]FASTAAdd to basket
Also known as: BreDnm15

The sequence of this isoform differs from the canonical sequence as follows:
     845-867: SLGAWRLNSPQGKHENRAGKARL → RITISDP

Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 6 (identifier: P39053-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.
     846-867: LGAWRLNSPQGKHENRAGKARL → RKGPASPTRPAAPRPTEAPLLDL

Note: PubMed:9143510 (AAA37324) sequence has a frameshift in position 844.Combined sources
Show »
Length:864
Mass (Da):97,284
Checksum:i12CA402BCCCF2936
GO

Sequence cautioni

The sequence BAD90284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135V → A in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti450P → R in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti531I → S in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti573R → H in BAE25726 (PubMed:16141072).Curated1
Sequence conflicti600Y → N in AAA37318 (PubMed:9143510).Curated1
Sequence conflicti703A → V in AAH58623 (PubMed:15489334).Curated1
Sequence conflicti722A → R in AAA37319 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37323 (PubMed:9143510).Curated1
Sequence conflicti722A → R in AAA37324 (PubMed:9143510).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007643407 – 444MAFET…RQCTK → LAFEATVKKQVQKLKEPSIK CVDMVVSELTSTIRKCSE in isoform 3. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_007644516 – 519Missing in isoform 6. 2 Publications4
Alternative sequenceiVSP_007645845 – 867SLGAW…GKARL → RITISDP in isoform 3 and isoform 5. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_007647846 – 867LGAWR…GKARL → RSGQASPSRPESPRPPFDL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_024845846 – 867LGAWR…GKARL → RKGPASPTRPAAPRPTEAPL LDL in isoform 6. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29457 mRNA Translation: AAA37319.1
L31395 mRNA Translation: AAA37318.1
L31396 mRNA Translation: AAA37323.1
L31397 mRNA Translation: AAA37324.1 Frameshift.
AK011651 mRNA Translation: BAB27759.1
AK144142 mRNA Translation: BAE25726.1
AK220483 mRNA Translation: BAD90284.1 Different initiation.
AL808027 Genomic DNA Translation: CAM15852.1
AL808027 Genomic DNA Translation: CAM15853.1
AL808027 Genomic DNA Translation: CAM15855.1
AL808027 Genomic DNA Translation: CAM15857.1
BC034679 mRNA Translation: AAH34679.1
BC058623 mRNA Translation: AAH58623.1
AF170568 Genomic DNA Translation: AAF24220.1
CCDSiCCDS38102.1 [P39053-6]
CCDS79772.1 [P39053-3]
RefSeqiNP_001288666.1, NM_001301737.1 [P39053-3]
NP_034195.2, NM_010065.3 [P39053-6]
XP_006497718.2, XM_006497655.2 [P39053-4]
XP_006497721.2, XM_006497658.3 [P39053-3]
XP_006497722.2, XM_006497659.3 [P39053-3]
XP_006497723.2, XM_006497660.2 [P39053-3]
XP_006497724.2, XM_006497661.2 [P39053-5]
XP_017170817.1, XM_017315328.1 [P39053-5]
UniGeneiMm.44736

Genome annotation databases

EnsembliENSMUST00000078352; ENSMUSP00000077461; ENSMUSG00000026825 [P39053-3]
ENSMUST00000091089; ENSMUSP00000088618; ENSMUSG00000026825 [P39053-6]
ENSMUST00000113350; ENSMUSP00000108977; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113352; ENSMUSP00000108979; ENSMUSG00000026825 [P39053-5]
ENSMUST00000113365; ENSMUSP00000108992; ENSMUSG00000026825 [P39053-4]
ENSMUST00000139624; ENSMUSP00000122679; ENSMUSG00000026825 [P39053-1]
ENSMUST00000202578; ENSMUSP00000143955; ENSMUSG00000026825 [P39053-3]
GeneIDi13429
KEGGimmu:13429
UCSCiuc008jfc.2 mouse [P39053-6]
uc008jfd.3 mouse [P39053-3]
uc029twn.1 mouse [P39053-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDYN1_MOUSE
AccessioniPrimary (citable) accession number: P39053
Secondary accession number(s): A2AN50
, A2AN51, A2AN54, A2AN55, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 20, 2003
Last modified: July 18, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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