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Protein

Cadherin-4

Gene

Cdh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis
R-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
Gene namesi
Name:Cdh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:99218 Cdh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini167 – 731ExtracellularSequence analysisAdd BLAST565
Transmembranei732 – 753HelicalSequence analysisAdd BLAST22
Topological domaini754 – 913CytoplasmicSequence analysisAdd BLAST160

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000375121 – 166Sequence analysisAdd BLAST146
ChainiPRO_0000003752167 – 913Cadherin-4Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP39038
PaxDbiP39038
PeptideAtlasiP39038
PRIDEiP39038
TopDownProteomicsiP39038

PTM databases

iPTMnetiP39038
PhosphoSitePlusiP39038

Expressioni

Tissue specificityi

Distributed widely in mouse tissues with high levels present in brain, skeletal muscle and thymus.

Gene expression databases

BgeeiENSMUSG00000000305 Expressed in 282 organ(s), highest expression level in cochlea
CleanExiMM_CDH4
ExpressionAtlasiP39038 baseline and differential
GenevisibleiP39038 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198639, 1 interactor
IntActiP39038, 1 interactor
MINTiP39038
STRINGi10090.ENSMUSP00000000314

Structurei

3D structure databases

ProteinModelPortaliP39038
SMRiP39038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 274Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini275 – 389Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini390 – 504Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini505 – 610Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini611 – 721Cadherin 5PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi870 – 885Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP39038
KOiK06797
OMAiNWLHINT
OrthoDBiEOG091G01FV
PhylomeDBiP39038
TreeFamiTF316817

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P39038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTGSVLPLL LLGLSGALRA HREDLTVREA CKAGFSEEGY TALISPNVLE
60 70 80 90 100
GEKLLKVEFS SCVGTKGMQY ETNSLDFKVG ADGTVFATRE LKIPSEQVAF
110 120 130 140 150
TVTARERQSA EQWAAMVRLL VAQTSSAHSE HKKGQTVALD PSQPPNDTLL
160 170 180 190 200
PWPQHQSSGG LRRQKRDWVI PPINVPENSR GPFPQQLVRI RSDKDNDIPI
210 220 230 240 250
RYSITGVGAD QPPMEVFNID SMSGRMYVTR PMDREERASY HLRAHAVDMN
260 270 280 290 300
GNKVENPIDL YIYVIDMNDN RPEFINQVYN GSVDEGSKPG TYVMTVTAND
310 320 330 340 350
ADDSTTANGM VRYRIVTQTP QSPSQNMFTI NSETGDIVTV AAGLDREKVQ
360 370 380 390 400
QYTVIVQATD MEGNLNYGLS NTATAIITVT DVNDNPPEFT TSTFAGEVPE
410 420 430 440 450
NRIETVVANL TVMDRDQPHS PNWNAVYRII SGDPSGHFSV RTDPVTNEGM
460 470 480 490 500
VTVVKAVDYE LNRAFMLTVM VSNQAPLASG IQMSFQSTAG VTISVTDVNE
510 520 530 540 550
APYFPSNHKL IRLEEGVPAG TALTTFSAVD PDRFMQQAVR YSKLSDPANW
560 570 580 590 600
LHINTSNGQI TTAAILDRES LYTKNNVYEA TFLAADNGIP PASGTGTLQI
610 620 630 640 650
YLIDINDNAP QLLPKEAQIC ERPGLNAINI TAADADMDPN IGPYVFELPF
660 670 680 690 700
IPTTVRKNWT ITRLNGDYAQ LSLRILYLEA GVYDVPIIVT DSGNPPLSNT
710 720 730 740 750
SVIKVKVCPC DENGDCTTVG AVAAAGLGTG AIVAILICIV ILLIMVLLFV
760 770 780 790 800
VWMKRREKER HTKQLLIDPE DDVRDNILKY DEEGGGEEDQ DYDLSQLQQP
810 820 830 840 850
EAMEHVLSKT PGVRRVDERP VGAEPQYPVR PVVPHPGDIG DFINEGLRAA
860 870 880 890 900
DNDPTAPPYD SLLVFDYEGS GSTAGSVSSL NSSSSGDQDY DYLNDWGPRF
910
KKLADMYGGG EED
Length:913
Mass (Da):100,030
Last modified:February 1, 1995 - v1
Checksum:i1245A8CE8C338481
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZV4Q80ZV4_MOUSE
Cadherin-4
Cdh4
334Annotation score:
F6QV10F6QV10_MOUSE
Cadherin-4
Cdh4
23Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69966 mRNA Translation: CAA49589.1
D14888 mRNA Translation: BAA03605.1
CCDSiCCDS17164.1
PIRiA47543
RefSeqiNP_033997.1, NM_009867.3
UniGeneiMm.184711

Genome annotation databases

EnsembliENSMUST00000000314; ENSMUSP00000000314; ENSMUSG00000000305
GeneIDi12561
KEGGimmu:12561
UCSCiuc008ohv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69966 mRNA Translation: CAA49589.1
D14888 mRNA Translation: BAA03605.1
CCDSiCCDS17164.1
PIRiA47543
RefSeqiNP_033997.1, NM_009867.3
UniGeneiMm.184711

3D structure databases

ProteinModelPortaliP39038
SMRiP39038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198639, 1 interactor
IntActiP39038, 1 interactor
MINTiP39038
STRINGi10090.ENSMUSP00000000314

PTM databases

iPTMnetiP39038
PhosphoSitePlusiP39038

Proteomic databases

MaxQBiP39038
PaxDbiP39038
PeptideAtlasiP39038
PRIDEiP39038
TopDownProteomicsiP39038

Protocols and materials databases

DNASUi12561
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000314; ENSMUSP00000000314; ENSMUSG00000000305
GeneIDi12561
KEGGimmu:12561
UCSCiuc008ohv.2 mouse

Organism-specific databases

CTDi1002
MGIiMGI:99218 Cdh4

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP39038
KOiK06797
OMAiNWLHINT
OrthoDBiEOG091G01FV
PhylomeDBiP39038
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis
R-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PROiPR:P39038
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000305 Expressed in 282 organ(s), highest expression level in cochlea
CleanExiMM_CDH4
ExpressionAtlasiP39038 baseline and differential
GenevisibleiP39038 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH4_MOUSE
AccessioniPrimary (citable) accession number: P39038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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