UniProtKB - P39023 (RL3_HUMAN)
Protein
60S ribosomal protein L3
Gene
RPL3
Organism
Homo sapiens (Human)
Status
Functioni
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.1 Publication
GO - Molecular functioni
- 5S rRNA binding Source: Ensembl
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cellular response to interleukin-4 Source: Ensembl
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- ribosomal large subunit assembly Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: ProtInc
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P39023 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L3Alternative name(s): HIV-1 TAR RNA-binding protein B Short name: TARBP-B Large ribosomal subunit protein uL31 Publication |
Gene namesi | Name:RPL3 ORF Names:OK/SW-cl.32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10332, RPL3 |
MIMi | 604163, gene |
neXtProti | NX_P39023 |
VEuPathDBi | HostDB:ENSG00000100316.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
- cytosolic large ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- protein-containing complex Source: UniProtKB
- synapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6122 |
OpenTargetsi | ENSG00000100316 |
PharmGKBi | PA34713 |
Miscellaneous databases
Pharosi | P39023, Tbio |
Chemistry databases
DrugBanki | DB02494, (S)-3-phenyllactic acid DB07374, Anisomycin DB04865, Omacetaxine mepesuccinate DB08437, Puromycin DB09092, Xanthinol |
Genetic variation databases
BioMutai | RPL3 |
DMDMi | 730565 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000077227 | 2 – 403 | 60S ribosomal protein L3Add BLAST | 402 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Cross-linki | 39 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 136 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 224 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 226 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 286 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 286 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 294 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 294 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 366 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 366 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 373 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 386 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 393 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 399 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P39023 |
jPOSTi | P39023 |
MassIVEi | P39023 |
MaxQBi | P39023 |
PaxDbi | P39023 |
PeptideAtlasi | P39023 |
PRIDEi | P39023 |
ProteomicsDBi | 55309 |
TopDownProteomicsi | P39023 |
2D gel databases
SWISS-2DPAGEi | P39023 |
PTM databases
iPTMneti | P39023 |
MetOSitei | P39023 |
PhosphoSitePlusi | P39023 |
SwissPalmi | P39023 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100316, Expressed in female gonad and 247 other tissues |
ExpressionAtlasi | P39023, baseline and differential |
Genevisiblei | P39023, HS |
Organism-specific databases
HPAi | ENSG00000100316, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P39023
With | #Exp. | IntAct |
---|---|---|
WFS1 [O76024] | 3 | EBI-1056348,EBI-720609 |
Protein-protein interaction databases
BioGRIDi | 112042, 297 interactors |
CORUMi | P39023 |
IntActi | P39023, 105 interactors |
MINTi | P39023 |
STRINGi | 9606.ENSP00000346001 |
Miscellaneous databases
RNActi | P39023, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL3 family.Curated
Phylogenomic databases
eggNOGi | KOG0746, Eukaryota |
GeneTreei | ENSGT00390000017606 |
HOGENOMi | CLU_033361_2_1_1 |
InParanoidi | P39023 |
OMAi | HQRTEYN |
OrthoDBi | 793191at2759 |
PhylomeDBi | P39023 |
TreeFami | TF300555 |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P39023-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK
60 70 80 90 100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR
110 120 130 140 150
TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF
160 170 180 190 200
SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER
210 220 230 240 250
LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK
260 270 280 290 300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
310 320 330 340 350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS
360 370 380 390 400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE
EGA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C422 | H7C422_HUMAN | 60S ribosomal protein L3 | RPL3 | 305 | Annotation score: | ||
G5E9G0 | G5E9G0_HUMAN | 60S ribosomal protein L3 | RPL3 ASC-1, hCG_2015191 | 351 | Annotation score: | ||
B5MCW2 | B5MCW2_HUMAN | 60S ribosomal protein L3 | RPL3 | 272 | Annotation score: | ||
H7C3M2 | H7C3M2_HUMAN | 60S ribosomal protein L3 | RPL3 | 261 | Annotation score: | ||
F8WCR1 | F8WCR1_HUMAN | 60S ribosomal protein L3 | RPL3 | 180 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | S → T in AAA91344 (PubMed:7576925).Curated | 1 | |
Sequence conflicti | 260 | A → V in AAA91344 (PubMed:7576925).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069220 | 11 | H → R Rare variant found in a Diamond-Blackfan anemia patient; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1569162425Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73460 mRNA Translation: CAA51839.1 AB062291 mRNA Translation: BAB93474.1 CR456566 mRNA Translation: CAG30452.1 AK315693 mRNA Translation: BAG38056.1 AL022326 Genomic DNA No translation available. BC002408 mRNA Translation: AAH02408.1 BC006483 mRNA Translation: AAH06483.1 BC008003 mRNA Translation: AAH08003.1 BC012146 mRNA Translation: AAH12146.1 BC012786 mRNA Translation: AAH12786.1 BC013674 mRNA Translation: AAH13674.1 BC014017 mRNA Translation: AAH14017.1 BC015032 mRNA Translation: AAH15032.1 BC015767 mRNA Translation: AAH15767.1 BC063662 mRNA Translation: AAH63662.1 BC088373 mRNA Translation: AAH88373.1 BC107711 mRNA Translation: AAI07712.1 M90054 mRNA Translation: AAA60291.1 L22453 mRNA Translation: AAA91344.1 AB007166 Genomic DNA Translation: BAA25828.1 |
CCDSi | CCDS13988.1 |
PIRi | S34195 |
RefSeqi | NP_000958.1, NM_000967.3 |
Genome annotation databases
Ensembli | ENST00000216146; ENSP00000346001; ENSG00000100316 |
GeneIDi | 6122 |
KEGGi | hsa:6122 |
UCSCi | uc003axi.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73460 mRNA Translation: CAA51839.1 AB062291 mRNA Translation: BAB93474.1 CR456566 mRNA Translation: CAG30452.1 AK315693 mRNA Translation: BAG38056.1 AL022326 Genomic DNA No translation available. BC002408 mRNA Translation: AAH02408.1 BC006483 mRNA Translation: AAH06483.1 BC008003 mRNA Translation: AAH08003.1 BC012146 mRNA Translation: AAH12146.1 BC012786 mRNA Translation: AAH12786.1 BC013674 mRNA Translation: AAH13674.1 BC014017 mRNA Translation: AAH14017.1 BC015032 mRNA Translation: AAH15032.1 BC015767 mRNA Translation: AAH15767.1 BC063662 mRNA Translation: AAH63662.1 BC088373 mRNA Translation: AAH88373.1 BC107711 mRNA Translation: AAI07712.1 M90054 mRNA Translation: AAA60291.1 L22453 mRNA Translation: AAA91344.1 AB007166 Genomic DNA Translation: BAA25828.1 |
CCDSi | CCDS13988.1 |
PIRi | S34195 |
RefSeqi | NP_000958.1, NM_000967.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | LB | 1-403 | [»] | |
4V6X | electron microscopy | 5.00 | CB | 1-403 | [»] | |
5AJ0 | electron microscopy | 3.50 | AB | 1-403 | [»] | |
5LKS | electron microscopy | 3.60 | LB | 1-403 | [»] | |
5T2C | electron microscopy | 3.60 | E | 1-403 | [»] | |
6EK0 | electron microscopy | 2.90 | LB | 1-403 | [»] | |
6IP5 | electron microscopy | 3.90 | 1E | 1-403 | [»] | |
6IP6 | electron microscopy | 4.50 | 1E | 1-403 | [»] | |
6IP8 | electron microscopy | 3.90 | 1E | 1-403 | [»] | |
6LQM | electron microscopy | 3.09 | B | 1-403 | [»] | |
6LSR | electron microscopy | 3.13 | B | 1-403 | [»] | |
6LSS | electron microscopy | 3.23 | B | 1-403 | [»] | |
6LU8 | electron microscopy | 3.13 | B | 1-403 | [»] | |
6OLE | electron microscopy | 3.10 | B | 2-398 | [»] | |
6OLF | electron microscopy | 3.90 | B | 2-398 | [»] | |
6OLG | electron microscopy | 3.40 | AB | 2-395 | [»] | |
6OLI | electron microscopy | 3.50 | B | 2-398 | [»] | |
6OLZ | electron microscopy | 3.90 | AB | 2-395 | [»] | |
6OM0 | electron microscopy | 3.10 | B | 2-398 | [»] | |
6OM7 | electron microscopy | 3.70 | B | 2-398 | [»] | |
6QZP | electron microscopy | 2.90 | LB | 2-403 | [»] | |
6W6L | electron microscopy | 3.84 | B | 1-403 | [»] | |
6XA1 | electron microscopy | 2.80 | LB | 2-397 | [»] | |
6Y0G | electron microscopy | 3.20 | LB | 1-403 | [»] | |
6Y2L | electron microscopy | 3.00 | LB | 1-403 | [»] | |
6Y57 | electron microscopy | 3.50 | LB | 1-403 | [»] | |
6Y6X | electron microscopy | 2.80 | LB | 2-398 | [»] | |
6Z6L | electron microscopy | 3.00 | LB | 1-403 | [»] | |
6Z6M | electron microscopy | 3.10 | LB | 1-403 | [»] | |
6Z6N | electron microscopy | 2.90 | LB | 1-403 | [»] | |
6ZM7 | electron microscopy | 2.70 | LB | 1-403 | [»] | |
6ZME | electron microscopy | 3.00 | LB | 1-403 | [»] | |
6ZMI | electron microscopy | 2.60 | LB | 1-403 | [»] | |
6ZMO | electron microscopy | 3.10 | LB | 1-403 | [»] | |
SMRi | P39023 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112042, 297 interactors |
CORUMi | P39023 |
IntActi | P39023, 105 interactors |
MINTi | P39023 |
STRINGi | 9606.ENSP00000346001 |
Chemistry databases
DrugBanki | DB02494, (S)-3-phenyllactic acid DB07374, Anisomycin DB04865, Omacetaxine mepesuccinate DB08437, Puromycin DB09092, Xanthinol |
PTM databases
iPTMneti | P39023 |
MetOSitei | P39023 |
PhosphoSitePlusi | P39023 |
SwissPalmi | P39023 |
Genetic variation databases
BioMutai | RPL3 |
DMDMi | 730565 |
2D gel databases
SWISS-2DPAGEi | P39023 |
Proteomic databases
EPDi | P39023 |
jPOSTi | P39023 |
MassIVEi | P39023 |
MaxQBi | P39023 |
PaxDbi | P39023 |
PeptideAtlasi | P39023 |
PRIDEi | P39023 |
ProteomicsDBi | 55309 |
TopDownProteomicsi | P39023 |
Protocols and materials databases
Antibodypediai | 1245, 270 antibodies |
DNASUi | 6122 |
Genome annotation databases
Ensembli | ENST00000216146; ENSP00000346001; ENSG00000100316 |
GeneIDi | 6122 |
KEGGi | hsa:6122 |
UCSCi | uc003axi.4, human |
Organism-specific databases
CTDi | 6122 |
DisGeNETi | 6122 |
GeneCardsi | RPL3 |
HGNCi | HGNC:10332, RPL3 |
HPAi | ENSG00000100316, Low tissue specificity |
MIMi | 604163, gene |
neXtProti | NX_P39023 |
OpenTargetsi | ENSG00000100316 |
PharmGKBi | PA34713 |
VEuPathDBi | HostDB:ENSG00000100316.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0746, Eukaryota |
GeneTreei | ENSGT00390000017606 |
HOGENOMi | CLU_033361_2_1_1 |
InParanoidi | P39023 |
OMAi | HQRTEYN |
OrthoDBi | 793191at2759 |
PhylomeDBi | P39023 |
TreeFami | TF300555 |
Enzyme and pathway databases
PathwayCommonsi | P39023 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6122, 771 hits in 883 CRISPR screens |
ChiTaRSi | RPL3, human |
GeneWikii | RPL3 |
GenomeRNAii | 6122 |
Pharosi | P39023, Tbio |
PROi | PR:P39023 |
RNActi | P39023, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100316, Expressed in female gonad and 247 other tissues |
ExpressionAtlasi | P39023, baseline and differential |
Genevisiblei | P39023, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL3_HUMAN | |
Accessioni | P39023Primary (citable) accession number: P39023 Secondary accession number(s): B2RDV9, Q15548, Q5I0G0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families