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UniProtKB - P39023 (RL3_HUMAN)

Entry version 215 (07 Apr 2021)
Sequence version 2 (23 Jan 2007)
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Protein

60S ribosomal protein L3

Gene

RPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P39023

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P39023

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L3
Alternative name(s):
HIV-1 TAR RNA-binding protein B
Short name:
TARBP-B
Large ribosomal subunit protein uL31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL3
ORF Names:OK/SW-cl.32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10332, RPL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604163, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P39023

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100316.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6122

Open Targets

More...OpenTargetsi		ENSG00000100316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34713

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P39023, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin
DB04865, Omacetaxine mepesuccinate
DB08437, Puromycin
DB09092, Xanthinol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		730565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000772272 – 40360S ribosomal protein L3Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei136N6-acetyllysineBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei286N6-acetyllysine; alternateBy similarity1
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei294N6-acetyllysine; alternateCombined sources1
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei304PhosphoserineCombined sources1
Modified residuei366N6-acetyllysine; alternateCombined sources1
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei373N6-acetyllysineBy similarity1
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P39023

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P39023

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P39023

MaxQB - The MaxQuant DataBase

More...MaxQBi		P39023

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39023

PeptideAtlas

More...PeptideAtlasi		P39023

PRoteomics IDEntifications database

More...PRIDEi		P39023

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55309

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P39023

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P39023

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39023

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P39023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P39023

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P39023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100316, Expressed in female gonad and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P39023, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P39023, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100316, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (Probable).

Interacts with METTL18 (PubMed:23349634).

Interacts with DHX33 (PubMed:26100019).

1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112042, 315 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P39023

Protein interaction database and analysis system

More...IntActi		P39023, 116 interactors

Molecular INTeraction database

More...MINTi		P39023

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P39023, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39023

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0746, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033361_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39023

Identification of Orthologs from Complete Genome Data

More...OMAi		HQRTEYN

Database of Orthologous Groups

More...OrthoDBi		793191at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39023

TreeFam database of animal gene trees

More...TreeFami		TF300555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000597, Ribosomal_L3
IPR019926, Ribosomal_L3_CS
IPR009000, Transl_B-barrel_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00297, Ribosomal_L3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50447, SSF50447, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00474, RIBOSOMAL_L3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P39023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK 
        60         70         80         90        100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR 
       110        120        130        140        150
TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF 
       160        170        180        190        200
SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER 
       210        220        230        240        250
LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK 
       260        270        280        290        300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK 
       310        320        330        340        350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS 
       360        370        380        390        400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE 

EGA
Length:403
Mass (Da):46,109
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA607CEE75CF62148
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C422H7C422_HUMAN
60S ribosomal protein L3
RPL3
305Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9G0G5E9G0_HUMAN
60S ribosomal protein L3
RPL3 ASC-1, hCG_2015191
351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCW2B5MCW2_HUMAN
60S ribosomal protein L3
RPL3
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3M2H7C3M2_HUMAN
60S ribosomal protein L3
RPL3
261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCR1F8WCR1_HUMAN
60S ribosomal protein L3
RPL3
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22S → T in AAA91344 (PubMed:7576925).Curated1
Sequence conflicti260A → V in AAA91344 (PubMed:7576925).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06922011H → R Rare variant found in a Diamond-Blackfan anemia patient; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1569162425Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X73460 mRNA Translation: CAA51839.1
AB062291 mRNA Translation: BAB93474.1
CR456566 mRNA Translation: CAG30452.1
AK315693 mRNA Translation: BAG38056.1
AL022326 Genomic DNA No translation available.
BC002408 mRNA Translation: AAH02408.1
BC006483 mRNA Translation: AAH06483.1
BC008003 mRNA Translation: AAH08003.1
BC012146 mRNA Translation: AAH12146.1
BC012786 mRNA Translation: AAH12786.1
BC013674 mRNA Translation: AAH13674.1
BC014017 mRNA Translation: AAH14017.1
BC015032 mRNA Translation: AAH15032.1
BC015767 mRNA Translation: AAH15767.1
BC063662 mRNA Translation: AAH63662.1
BC088373 mRNA Translation: AAH88373.1
BC107711 mRNA Translation: AAI07712.1
M90054 mRNA Translation: AAA60291.1
L22453 mRNA Translation: AAA91344.1
AB007166 Genomic DNA Translation: BAA25828.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13988.1

Protein sequence database of the Protein Information Resource

More...PIRi		S34195

NCBI Reference Sequences

More...RefSeqi		NP_000958.1, NM_000967.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216146; ENSP00000346001; ENSG00000100316

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6122

UCSC genome browser

More...UCSCi		uc003axi.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73460 mRNA Translation: CAA51839.1
AB062291 mRNA Translation: BAB93474.1
CR456566 mRNA Translation: CAG30452.1
AK315693 mRNA Translation: BAG38056.1
AL022326 Genomic DNA No translation available.
BC002408 mRNA Translation: AAH02408.1
BC006483 mRNA Translation: AAH06483.1
BC008003 mRNA Translation: AAH08003.1
BC012146 mRNA Translation: AAH12146.1
BC012786 mRNA Translation: AAH12786.1
BC013674 mRNA Translation: AAH13674.1
BC014017 mRNA Translation: AAH14017.1
BC015032 mRNA Translation: AAH15032.1
BC015767 mRNA Translation: AAH15767.1
BC063662 mRNA Translation: AAH63662.1
BC088373 mRNA Translation: AAH88373.1
BC107711 mRNA Translation: AAI07712.1
M90054 mRNA Translation: AAA60291.1
L22453 mRNA Translation: AAA91344.1
AB007166 Genomic DNA Translation: BAA25828.1
CCDSiCCDS13988.1
PIRiS34195
RefSeqiNP_000958.1, NM_000967.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LB1-403[»]
4V6Xelectron microscopy5.00CB1-403[»]
5AJ0electron microscopy3.50AB1-403[»]
5LKSelectron microscopy3.60LB1-403[»]
5T2Celectron microscopy3.60E1-403[»]
6EK0electron microscopy2.90LB1-403[»]
6IP5electron microscopy3.901E1-403[»]
6IP6electron microscopy4.501E1-403[»]
6IP8electron microscopy3.901E1-403[»]
6LQMelectron microscopy3.09B1-403[»]
6LSRelectron microscopy3.13B1-403[»]
6LSSelectron microscopy3.23B1-403[»]
6LU8electron microscopy3.13B1-403[»]
6OLEelectron microscopy3.10B2-398[»]
6OLFelectron microscopy3.90B2-398[»]
6OLGelectron microscopy3.40AB2-395[»]
6OLIelectron microscopy3.50B2-398[»]
6OLZelectron microscopy3.90AB2-395[»]
6OM0electron microscopy3.10B2-398[»]
6OM7electron microscopy3.70B2-398[»]
6QZPelectron microscopy2.90LB2-403[»]
6W6Lelectron microscopy3.84B1-403[»]
6XA1electron microscopy2.80LB2-397[»]
6Y0Gelectron microscopy3.20LB1-403[»]
6Y2Lelectron microscopy3.00LB1-403[»]
6Y57electron microscopy3.50LB1-403[»]
6Y6Xelectron microscopy2.80LB2-398[»]
6Z6Lelectron microscopy3.00LB1-403[»]
6Z6Melectron microscopy3.10LB1-403[»]
6Z6Nelectron microscopy2.90LB1-403[»]
6ZM7electron microscopy2.70LB1-403[»]
6ZMEelectron microscopy3.00LB1-403[»]
6ZMIelectron microscopy2.60LB1-403[»]
6ZMOelectron microscopy3.10LB1-403[»]
SMRiP39023
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112042, 315 interactors
CORUMiP39023
IntActiP39023, 116 interactors
MINTiP39023
STRINGi9606.ENSP00000346001

Chemistry databases

DrugBankiDB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin
DB04865, Omacetaxine mepesuccinate
DB08437, Puromycin
DB09092, Xanthinol

PTM databases

iPTMnetiP39023
MetOSiteiP39023
PhosphoSitePlusiP39023
SwissPalmiP39023

Genetic variation databases

BioMutaiRPL3
DMDMi730565

2D gel databases

SWISS-2DPAGEiP39023

Proteomic databases

EPDiP39023
jPOSTiP39023
MassIVEiP39023
MaxQBiP39023
PaxDbiP39023
PeptideAtlasiP39023
PRIDEiP39023
ProteomicsDBi55309
TopDownProteomicsiP39023

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1245, 277 antibodies

The DNASU plasmid repository

More...DNASUi		6122

Genome annotation databases

EnsembliENST00000216146; ENSP00000346001; ENSG00000100316
GeneIDi6122
KEGGihsa:6122
UCSCiuc003axi.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6122
DisGeNETi6122

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPL3
HGNCiHGNC:10332, RPL3
HPAiENSG00000100316, Low tissue specificity
MIMi604163, gene
neXtProtiNX_P39023
OpenTargetsiENSG00000100316
PharmGKBiPA34713
VEuPathDBiHostDB:ENSG00000100316.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0746, Eukaryota
GeneTreeiENSGT00390000017606
HOGENOMiCLU_033361_2_1_1
InParanoidiP39023
OMAiHQRTEYN
OrthoDBi793191at2759
PhylomeDBiP39023
TreeFamiTF300555

Enzyme and pathway databases

PathwayCommonsiP39023
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP39023

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6122, 797 hits in 969 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6122
PharosiP39023, Tbio

Protein Ontology

More...PROi		PR:P39023
RNActiP39023, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100316, Expressed in female gonad and 247 other tissues
ExpressionAtlasiP39023, baseline and differential
GenevisibleiP39023, HS

Family and domain databases

InterProiView protein in InterPro
IPR000597, Ribosomal_L3
IPR019926, Ribosomal_L3_CS
IPR009000, Transl_B-barrel_sf
PfamiView protein in Pfam
PF00297, Ribosomal_L3, 1 hit
SUPFAMiSSF50447, SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS00474, RIBOSOMAL_L3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39023
Secondary accession number(s): B2RDV9, Q15548, Q5I0G0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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