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Entry version 195 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

40S ribosomal protein S19

Gene

RPS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P39019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S19
Alternative name(s):
Small ribosomal subunit protein eS191 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10402 RPS19

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603474 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P39019

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 1 (DBA1)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant dbSNP:rs104894717EnsemblClinVar.1
Natural variantiVAR_04614517A → P in DBA1. 1 PublicationCorresponds to variant dbSNP:rs782329429EnsemblClinVar.1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant dbSNP:rs147508369EnsemblClinVar.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 PublicationsCorresponds to variant dbSNP:rs1555841301EnsemblClinVar.1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant dbSNP:rs104894711EnsemblClinVar.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant dbSNP:rs786200936EnsemblClinVar.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6223

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RPS19

MalaCards human disease database

More...
MalaCardsi
RPS19
MIMi105650 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105372

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
124 Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34803

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638 Artenimol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
730640

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001538102 – 14540S ribosomal protein S19Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23N6-acetyllysineCombined sources1
Modified residuei67Omega-N-methylarginineCombined sources1
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei143N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-436
CPTAC-437

Encyclopedia of Proteome Dynamics

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EPDi
P39019

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P39019

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P39019

MaxQB - The MaxQuant DataBase

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MaxQBi
P39019

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39019

PeptideAtlas

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PeptideAtlasi
P39019

PRoteomics IDEntifications database

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PRIDEi
P39019

ProteomicsDB human proteome resource

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ProteomicsDBi
55308

Consortium for Top Down Proteomics

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TopDownProteomicsi
P39019

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P39019

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P39019

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P39019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105372 Expressed in 231 organ(s), highest expression level in thoracic mammary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P39019 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P39019 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063217

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RPS19BP1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PIM1P113097EBI-354451,EBI-696621

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112137, 210 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P39019

Protein interaction database and analysis system

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IntActi
P39019, 41 interactors

Molecular INTeraction database

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MINTi
P39019

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000470972

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P39019

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3411 Eukaryota
COG2238 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013102

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P39019

KEGG Orthology (KO)

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KOi
K02966

Identification of Orthologs from Complete Genome Data

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OMAi
YIDGPVG

Database of Orthologous Groups

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OrthoDBi
1434984at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P39019

TreeFam database of animal gene trees

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TreeFami
TF315008

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.2700, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001266 Ribosomal_S19e
IPR018277 Ribosomal_S19e_CS
IPR038111 Ribosomal_S19e_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

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PANTHERi
PTHR11710 PTHR11710, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01090 Ribosomal_S19e, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01413 Ribosomal_S19e, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00628 RIBOSOMAL_S19E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P39019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE
60 70 80 90 100
NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA
110 120 130 140
RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Length:145
Mass (Da):16,060
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i181F2DB898E56E41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6E2A0A075B6E2_HUMAN
40S ribosomal protein S19
RPS19
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYF7M0QYF7_HUMAN
40S ribosomal protein S19
RPS19
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2L9M0R2L9_HUMAN
40S ribosomal protein S19
RPS19
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXK4M0QXK4_HUMAN
40S ribosomal protein S19
RPS19
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R140M0R140_HUMAN
40S ribosomal protein S19
RPS19
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant dbSNP:rs104894717EnsemblClinVar.1
Natural variantiVAR_04614517A → P in DBA1. 1 PublicationCorresponds to variant dbSNP:rs782329429EnsemblClinVar.1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant dbSNP:rs147508369EnsemblClinVar.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 PublicationsCorresponds to variant dbSNP:rs1555841301EnsemblClinVar.1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant dbSNP:rs104894711EnsemblClinVar.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant dbSNP:rs786200936EnsemblClinVar.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M81757 mRNA Translation: AAA89070.1
AF092907, AF092906 Genomic DNA Translation: AAD13668.1
BC000023 mRNA Translation: AAH00023.1
BC007615 mRNA Translation: AAH07615.1
BC018616 mRNA Translation: AAH18616.1
AB007155 Genomic DNA Translation: BAA28593.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12588.1

Protein sequence database of the Protein Information Resource

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PIRi
I52692

NCBI Reference Sequences

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RefSeqi
NP_001013.1, NM_001022.3
NP_001308412.1, NM_001321483.1
NP_001308413.1, NM_001321484.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000593863; ENSP00000470004; ENSG00000105372
ENST00000598742; ENSP00000470972; ENSG00000105372
ENST00000600467; ENSP00000469228; ENSG00000105372

Database of genes from NCBI RefSeq genomes

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GeneIDi
6223

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6223

UCSC genome browser

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UCSCi
uc002ort.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA Translation: AAA89070.1
AF092907, AF092906 Genomic DNA Translation: AAD13668.1
BC000023 mRNA Translation: AAH00023.1
BC007615 mRNA Translation: AAH07615.1
BC018616 mRNA Translation: AAH18616.1
AB007155 Genomic DNA Translation: BAA28593.1
CCDSiCCDS12588.1
PIRiI52692
RefSeqiNP_001013.1, NM_001022.3
NP_001308412.1, NM_001321483.1
NP_001308413.1, NM_001321484.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
5LKSelectron microscopy3.60ST1-145[»]
5OA3electron microscopy4.30T1-145[»]
5T2Celectron microscopy3.60AU1-145[»]
5VYCX-ray6.00T1/T2/T3/T4/T5/T61-145[»]
6EK0electron microscopy2.90ST1-145[»]
6G18electron microscopy3.60T1-145[»]
6G4Selectron microscopy4.00T1-145[»]
6G4Welectron microscopy4.50T1-145[»]
6G51electron microscopy4.10T1-145[»]
6G53electron microscopy4.50T1-145[»]
6G5Helectron microscopy3.60T1-145[»]
6G5Ielectron microscopy3.50T1-145[»]
6IP5electron microscopy3.90201-145[»]
6IP6electron microscopy4.50201-145[»]
6IP8electron microscopy3.90201-145[»]
6OLEelectron microscopy3.10ST2-144[»]
6OLFelectron microscopy3.90ST2-144[»]
6OLGelectron microscopy3.40BT2-144[»]
6OLIelectron microscopy3.50ST2-144[»]
6OLZelectron microscopy3.90BT2-144[»]
6OM0electron microscopy3.10ST2-144[»]
6OM7electron microscopy3.70ST2-144[»]
6QZPelectron microscopy2.90ST2-144[»]
SMRiP39019
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112137, 210 interactors
CORUMiP39019
IntActiP39019, 41 interactors
MINTiP39019
STRINGi9606.ENSP00000470972

Chemistry databases

DrugBankiDB11638 Artenimol

PTM databases

iPTMnetiP39019
PhosphoSitePlusiP39019
SwissPalmiP39019

Polymorphism and mutation databases

BioMutaiRPS19
DMDMi730640

Proteomic databases

CPTACiCPTAC-436
CPTAC-437
EPDiP39019
jPOSTiP39019
MassIVEiP39019
MaxQBiP39019
PaxDbiP39019
PeptideAtlasiP39019
PRIDEiP39019
ProteomicsDBi55308
TopDownProteomicsiP39019

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6223
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372
ENST00000598742; ENSP00000470972; ENSG00000105372
ENST00000600467; ENSP00000469228; ENSG00000105372
GeneIDi6223
KEGGihsa:6223
UCSCiuc002ort.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6223
DisGeNETi6223

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS19
GeneReviewsiRPS19
HGNCiHGNC:10402 RPS19
HPAiHPA063217
MalaCardsiRPS19
MIMi105650 phenotype
603474 gene
neXtProtiNX_P39019
OpenTargetsiENSG00000105372
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34803

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3411 Eukaryota
COG2238 LUCA
GeneTreeiENSGT00390000013102
InParanoidiP39019
KOiK02966
OMAiYIDGPVG
OrthoDBi1434984at2759
PhylomeDBiP39019
TreeFamiTF315008

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP39019

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS19 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Ribosomal_protein_S19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6223

Pharos

More...
Pharosi
P39019

Protein Ontology

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PROi
PR:P39019

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105372 Expressed in 231 organ(s), highest expression level in thoracic mammary gland
ExpressionAtlasiP39019 baseline and differential
GenevisibleiP39019 HS

Family and domain databases

Gene3Di1.10.10.2700, 1 hit
InterProiView protein in InterPro
IPR001266 Ribosomal_S19e
IPR018277 Ribosomal_S19e_CS
IPR038111 Ribosomal_S19e_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11710 PTHR11710, 1 hit
PfamiView protein in Pfam
PF01090 Ribosomal_S19e, 1 hit
SMARTiView protein in SMART
SM01413 Ribosomal_S19e, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00628 RIBOSOMAL_S19E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39019
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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