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Protein

40S ribosomal protein S19

Gene

RPS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • erythrocyte differentiation Source: HGNC
  • killing of cells of other organism Source: UniProtKB
  • maturation of SSU-rRNA Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • monocyte chemotaxis Source: UniProtKB
  • negative regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • Notch signaling pathway Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • nucleolus organization Source: UniProtKB
  • positive regulation of cellular component movement Source: HGNC
  • positive regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • protein tetramerization Source: UniProtKB
  • response to extracellular stimulus Source: HGNC
  • ribosomal small subunit assembly Source: UniProtKB
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP39019

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19
Alternative name(s):
Small ribosomal subunit protein eS191 Publication
Gene namesi
Name:RPS19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105372.6
HGNCiHGNC:10402 RPS19
MIMi603474 gene
neXtProtiNX_P39019

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 1 (DBA1)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:105650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant dbSNP:rs104894717EnsemblClinVar.1
Natural variantiVAR_04614517A → P in DBA1. 1 Publication1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant dbSNP:rs147508369EnsemblClinVar.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant dbSNP:rs104894711EnsemblClinVar.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant dbSNP:rs786200936EnsemblClinVar.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi6223
GeneReviewsiRPS19
MalaCardsiRPS19
MIMi105650 phenotype
OpenTargetsiENSG00000105372
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34803

Polymorphism and mutation databases

BioMutaiRPS19
DMDMi730640

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001538102 – 14540S ribosomal protein S19Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei67Omega-N-methylarginineCombined sources1
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei143N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP39019
MaxQBiP39019
PaxDbiP39019
PeptideAtlasiP39019
PRIDEiP39019
ProteomicsDBi55308
TopDownProteomicsiP39019

PTM databases

iPTMnetiP39019
PhosphoSitePlusiP39019
SwissPalmiP39019

Expressioni

Tissue specificityi

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Gene expression databases

BgeeiENSG00000105372
CleanExiHS_RPS19
ExpressionAtlasiP39019 baseline and differential
GenevisibleiP39019 HS

Organism-specific databases

HPAiHPA063217

Interactioni

Subunit structurei

Interacts with RPS19BP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PIM1P113097EBI-354451,EBI-696621

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112137, 181 interactors
CORUMiP39019
IntActiP39019, 29 interactors
MINTiP39019
STRINGi9606.ENSP00000470004

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
5LKSelectron microscopy3.60ST1-145[»]
5OA3electron microscopy4.30T1-145[»]
5T2Celectron microscopy3.60AU1-145[»]
5VYCX-ray6.00T1/T2/T3/T4/T5/T61-145[»]
6EK0electron microscopy2.90ST1-145[»]
ProteinModelPortaliP39019
SMRiP39019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3411 Eukaryota
COG2238 LUCA
GeneTreeiENSGT00390000013102
HOVERGENiHBG000240
InParanoidiP39019
KOiK02966
OMAiYIDGPVG
OrthoDBiEOG091G0QM7
PhylomeDBiP39019
TreeFamiTF315008

Family and domain databases

Gene3Di1.10.10.2700, 1 hit
InterProiView protein in InterPro
IPR001266 Ribosomal_S19e
IPR018277 Ribosomal_S19e_CS
IPR038111 Ribosomal_S19e_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11710 PTHR11710, 1 hit
PfamiView protein in Pfam
PF01090 Ribosomal_S19e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003854 Ribosomal_S19e, 1 hit
SMARTiView protein in SMART
SM01413 Ribosomal_S19e, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00628 RIBOSOMAL_S19E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE
60 70 80 90 100
NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA
110 120 130 140
RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Length:145
Mass (Da):16,060
Last modified:January 23, 2007 - v2
Checksum:i181F2DB898E56E41
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant dbSNP:rs104894717EnsemblClinVar.1
Natural variantiVAR_04614517A → P in DBA1. 1 Publication1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant dbSNP:rs147508369EnsemblClinVar.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant dbSNP:rs104894711EnsemblClinVar.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant dbSNP:rs786200936EnsemblClinVar.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA Translation: AAA89070.1
AF092907, AF092906 Genomic DNA Translation: AAD13668.1
BC000023 mRNA Translation: AAH00023.1
BC007615 mRNA Translation: AAH07615.1
BC018616 mRNA Translation: AAH18616.1
AB007155 Genomic DNA Translation: BAA28593.1
CCDSiCCDS12588.1
PIRiI52692
RefSeqiNP_001013.1, NM_001022.3
NP_001308412.1, NM_001321483.1
NP_001308413.1, NM_001321484.1
UniGeneiHs.438429

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372
ENST00000598742; ENSP00000470972; ENSG00000105372
ENST00000600467; ENSP00000469228; ENSG00000105372
GeneIDi6223
KEGGihsa:6223
UCSCiuc002ort.4 human

Similar proteinsi

Entry informationi

Entry nameiRS19_HUMAN
AccessioniPrimary (citable) accession number: P39019
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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