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Entry version 175 (02 Jun 2021)
Sequence version 2 (17 Oct 2006)
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Protein

Suppressor protein MPT5

Gene

MPT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA. Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components. Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs. Multicopy suppressor of POP2 mutation. Required for high temperature growth.

1 Publication

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor protein MPT5
Alternative name(s):
Protein HTR1
Pumilio homology domain family member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPT5
Synonyms:HTR1, PUF5
Ordered Locus Names:YGL178W
ORF Names:BIC834
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003146, MPT5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGL178W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759231 – 859Suppressor protein MPT5Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei662PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39016

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39016

PRoteomics IDEntifications database

More...
PRIDEi
P39016

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39016

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33076, 1845 interactors

Database of interacting proteins

More...
DIPi
DIP-2271N

Protein interaction database and analysis system

More...
IntActi
P39016, 17 interactors

Molecular INTeraction database

More...
MINTi
P39016

STRING: functional protein association networks

More...
STRINGi
4932.YGL178W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P39016, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1859
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P39016

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 596PUM-HDPROSITE-ProRule annotationAdd BLAST409
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati209 – 247Pumilio 1Add BLAST39
Repeati248 – 283Pumilio 2Add BLAST36
Repeati284 – 320Pumilio 3Add BLAST37
Repeati325 – 362Pumilio 4Add BLAST38
Repeati363 – 400Pumilio 5Add BLAST38
Repeati401 – 438Pumilio 6Add BLAST38
Repeati439 – 474Pumilio 7Add BLAST36
Repeati503 – 539Pumilio 8Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 108DisorderedSequence analysisAdd BLAST24
Regioni620 – 658DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi644 – 658Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2049, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017863_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39016

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKCIFKF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07920, Pumilio, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033133, PUM-HD
IPR033712, Pumilio_RNA-bd
IPR001313, Pumilio_RNA-bd_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00806, PUF, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00025, Pumilio, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50302, PUM, 8 hits
PS50303, PUM_HD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39016-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINNEPFPSA DSASILTTST SNNSLMSYNH QPQLSINSVQ SLLEPVTPPP
60 70 80 90 100
LGQMNNKRNH QKAHSLDLSG FNQFISSTQS PLALMNNTST SNSANSFSPN
110 120 130 140 150
PNAASNSTGL SASMANPPAI LPLINEFDLE MDGPRRKSSH DFTVVAPSNS
160 170 180 190 200
GVNTSSLIME TPSSSVTPAA SLRNFSNSNN AASKCGVDNS SFGLSSSTSS
210 220 230 240 250
SMVEISALPL RDLDYIKLAT DQFGCRFLQK KLETPSESNM VRDLMYEQIK
260 270 280 290 300
PFFLDLILDP FGNYLVQKLC DYLTAEQKTL LIQTIYPNVF QISINQYGTR
310 320 330 340 350
SLQKIIDTVD NEVQIDLIIK GFSQEFTSIE QVVTLINDLN GNHVIQKCIF
360 370 380 390 400
KFSPSKFGFI IDAIVEQNNI ITISTHKHGC CVLQKLLSVC TLQQIFKISV
410 420 430 440 450
KIVQFLPGLI NDQFGNYIIQ FLLDIKELDF YLLAELFNRL SNELCQLSCL
460 470 480 490 500
KFSSNVVEKF IKKLFRIITG FIVNNNGGAS QRTAVASDDV INASMNILLT
510 520 530 540 550
TIDIFTVNLN VLIRDNFGNY ALQTLLDVKN YSPLLAYNKN SNAIGQNSSS
560 570 580 590 600
TLNYGNFCND FSLKIGNLIV LTKELLPSIK TTSYAKKIKL KVKAYAEATG
610 620 630 640 650
IPFTDISPQV TAMSHNNLQT INNENKNPHN KNSHNHNHNH NHNHAHNNNN
660 670 680 690 700
NNNQKSHTRH FSLPANAYHR RSNSSVTNNF SNQYAQDQKI HSPQQIMNFN
710 720 730 740 750
QNAYPSMGAP SFNSQTNPPL VSHNSLQNFD NRQFANLMAH PNSAAPIHSF
760 770 780 790 800
SSSNITNVNP NVSRGFKQPG FMMNETDKIN ANHFSPYSNA NSQNFNESFV
810 820 830 840 850
PRMQYQTEGA NWDSSLSMKS QHIGQGPYNQ VNMSRNASIS NMPAMNTART

SDELQFTLP
Length:859
Mass (Da):95,422
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B289BAF3CEA2200
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA05024 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA05172 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA58660 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA58663 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X83690 Genomic DNA Translation: CAA58660.1 Sequence problems.
X83690 Genomic DNA Translation: CAA58663.1 Sequence problems.
Z72700 Genomic DNA Translation: CAA96889.1
D25541 Genomic DNA Translation: BAA05024.1 Sequence problems.
D26184 Genomic DNA Translation: BAA05172.1 Sequence problems.
BK006941 Genomic DNA Translation: DAA07936.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64195

NCBI Reference Sequences

More...
RefSeqi
NP_011337.1, NM_001181043.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL178W_mRNA; YGL178W; YGL178W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL178W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83690 Genomic DNA Translation: CAA58660.1 Sequence problems.
X83690 Genomic DNA Translation: CAA58663.1 Sequence problems.
Z72700 Genomic DNA Translation: CAA96889.1
D25541 Genomic DNA Translation: BAA05024.1 Sequence problems.
D26184 Genomic DNA Translation: BAA05172.1 Sequence problems.
BK006941 Genomic DNA Translation: DAA07936.1
PIRiS64195
RefSeqiNP_011337.1, NM_001181043.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BYMX-ray2.71A201-600[»]
5BZ1X-ray2.15A201-600[»]
5BZ5X-ray2.80A201-600[»]
5BZUX-ray2.50A201-600[»]
5BZVX-ray2.35A201-600[»]
SMRiP39016
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi33076, 1845 interactors
DIPiDIP-2271N
IntActiP39016, 17 interactors
MINTiP39016
STRINGi4932.YGL178W

PTM databases

iPTMnetiP39016

Proteomic databases

MaxQBiP39016
PaxDbiP39016
PRIDEiP39016

Genome annotation databases

EnsemblFungiiYGL178W_mRNA; YGL178W; YGL178W
GeneIDi852697
KEGGisce:YGL178W

Organism-specific databases

SGDiS000003146, MPT5
VEuPathDBiFungiDB:YGL178W

Phylogenomic databases

eggNOGiKOG2049, Eukaryota
HOGENOMiCLU_017863_0_0_1
InParanoidiP39016
OMAiQKCIFKF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39016
RNActiP39016, protein

Family and domain databases

CDDicd07920, Pumilio, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033133, PUM-HD
IPR033712, Pumilio_RNA-bd
IPR001313, Pumilio_RNA-bd_rpt
PfamiView protein in Pfam
PF00806, PUF, 6 hits
SMARTiView protein in SMART
SM00025, Pumilio, 8 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50302, PUM, 8 hits
PS50303, PUM_HD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPT5_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39016
Secondary accession number(s): D6VTX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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