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Entry version 146 (02 Jun 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Bud emergence protein 4

Gene

BEM4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably acts as a GTPase-activating protein (GAP) for CDC42, RHO1, RHO2, and RHO4. Negative regulator of the pheromone-response pathway through the STE20 protein kinase. Involved in the control of polarized cell growth.

Miscellaneous

Present with 6330 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processPheromone response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bud emergence protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BEM4
Ordered Locus Names:YPL161C
ORF Names:P2561
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000006082, BEM4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPL161C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649101 – 633Bud emergence protein 4Add BLAST633

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39011

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39011

PRoteomics IDEntifications database

More...
PRIDEi
P39011

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDC11.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36022, 399 interactors

Database of interacting proteins

More...
DIPi
DIP-1208N

Protein interaction database and analysis system

More...
IntActi
P39011, 24 interactors

Molecular INTeraction database

More...
MINTi
P39011

STRING: functional protein association networks

More...
STRINGi
4932.YPL161C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P39011, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P39011

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQB4, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_436179_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39011

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANCLVDN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040144, RAP1GDS1

The PANTHER Classification System

More...
PANTHERi
PTHR10957, PTHR10957, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYEEILFGL QPILNASSIK DVPMNDVYLG SYLAVMDQLA VSLREPSNRD
60 70 80 90 100
IVGKTGLLLN LVRVLEQALD ICFHDTSISI NDKIAFYEIS SEVIRCIANA
110 120 130 140 150
IIDNDDNREI LLDSGGKKLL NYYIGGVLQL DEISSDKSED SLVDKLQMRS
160 170 180 190 200
VVLLRNFCIG NLKYTENLAP FIRGPLFVLL KTTQYSYLSS PEKVVLGSDL
210 220 230 240 250
LNDILKVNYS NVQISDLFFL SQYIKKISSN VQNKELQAME DGAVEAYSNT
260 270 280 290 300
ETQKFAGQGN QEYIEKEEED DEEDVNCELL LNLSTCLETI VAKDETINFT
310 320 330 340 350
NEEQLVLSMQ KNLILSLVCL ESKTFNNKLI VMRRLISCAG NISANLTNSN
360 370 380 390 400
KREQSLCIET IKSSASSYAL AAALMILCNS VASKSDAVAL LKLISLSELI
410 420 430 440 450
QVGSLLQDPL QYQGFLDLLR KLLNLENTMW LDIKDLFTLF QIMRRCHEQT
460 470 480 490 500
KYYNNLRSLL TNLLNKTLTV LPSSKIHNSI SSDPTIISFI AEHGTLTSCI
510 520 530 540 550
AMDKLLVSKK ALPKEAITSL WDSIFKFQNL GQAEQLSISD LFHITKTVGI
560 570 580 590 600
YLKDSSVTAD VNPIENILFK DYIQKLTLIL ETILSFKENK DKGSESCFNN
610 620 630
GKFIAGIILN IVKNTKCLTP EEQNLEALAK SFF
Length:633
Mass (Da):70,993
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22171643922650AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L27816 Genomic DNA Translation: AAB47774.1
X96770 Genomic DNA Translation: CAA65560.1
Z73517 Genomic DNA Translation: CAA97866.1
BK006949 Genomic DNA Translation: DAA11273.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45177

NCBI Reference Sequences

More...
RefSeqi
NP_015164.1, NM_001183975.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL161C_mRNA; YPL161C; YPL161C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL161C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27816 Genomic DNA Translation: AAB47774.1
X96770 Genomic DNA Translation: CAA65560.1
Z73517 Genomic DNA Translation: CAA97866.1
BK006949 Genomic DNA Translation: DAA11273.1
PIRiS45177
RefSeqiNP_015164.1, NM_001183975.1

3D structure databases

SMRiP39011
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36022, 399 interactors
DIPiDIP-1208N
IntActiP39011, 24 interactors
MINTiP39011
STRINGi4932.YPL161C

PTM databases

iPTMnetiP39011

Proteomic databases

MaxQBiP39011
PaxDbiP39011
PRIDEiP39011

Genome annotation databases

EnsemblFungiiYPL161C_mRNA; YPL161C; YPL161C
GeneIDi855942
KEGGisce:YPL161C

Organism-specific databases

SGDiS000006082, BEM4
VEuPathDBiFungiDB:YPL161C

Phylogenomic databases

eggNOGiENOG502QQB4, Eukaryota
HOGENOMiCLU_436179_0_0_1
InParanoidiP39011
OMAiANCLVDN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39011
RNActiP39011, protein

Family and domain databases

InterProiView protein in InterPro
IPR040144, RAP1GDS1
PANTHERiPTHR10957, PTHR10957, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBEM4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39011
Secondary accession number(s): D6W3K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 2, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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