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Protein

High-affinity hexose transporter HXT7

Gene

HXT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

Miscellaneous

Present with 7350 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • pentose transmembrane transporter activity Source: SGD

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER

Protein family/group databases

TCDBi2.A.1.1.31 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity hexose transporter HXT7
Gene namesi
Name:HXT7
Ordered Locus Names:YDR342C
ORF Names:D9651.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002750 HXT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
Transmembranei61 – 81Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini82 – 116ExtracellularSequence analysisAdd BLAST35
Transmembranei117 – 137Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini138 – 143CytoplasmicSequence analysis6
Transmembranei144 – 164Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini165 – 174ExtracellularSequence analysis10
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 201CytoplasmicSequence analysis6
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 236ExtracellularSequence analysisAdd BLAST14
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 340CytoplasmicSequence analysisAdd BLAST83
Transmembranei341 – 357Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini358 – 363ExtracellularSequence analysis6
Transmembranei364 – 381Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini382 – 388CytoplasmicSequence analysis7
Transmembranei389 – 409Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini410 – 431ExtracellularSequence analysisAdd BLAST22
Transmembranei432 – 452Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini453 – 469CytoplasmicSequence analysisAdd BLAST17
Transmembranei470 – 490Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini491ExtracellularSequence analysis1
Transmembranei492 – 512Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini513 – 570CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503971 – 570High-affinity hexose transporter HXT7Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei556PhosphothreonineCombined sources1
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP39004
PaxDbiP39004
PRIDEiP39004

PTM databases

iPTMnetiP39004

Interactioni

Protein-protein interaction databases

BioGridi32399, 57 interactors
DIPiDIP-5182N
IntActiP39004, 31 interactors
MINTiP39004
STRINGi4932.YDR342C

Structurei

3D structure databases

ProteinModelPortaliP39004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000202870
InParanoidiP39004
KOiK08139
OMAiAPKHYPG
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP
60 70 80 90 100
VVEIPKRPAS AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG
110 120 130 140 150
MKHKDGTNYL SKVRTGLIVS IFNIGCAIGG IILSKLGDMY GRKVGLIVVV
160 170 180 190 200
VIYIIGIIIQ IASINKWYQY FIGRIISGLG VGGIAVLSPM LISEVSPKHL
210 220 230 240 250
RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI
260 270 280 290 300
GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV
310 320 330 340 350
EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI
360 370 380 390 400
FKAVGLSDSF ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC
410 420 430 440 450
MVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIPYV
460 470 480 490 500
VVSETFPLRV KSKAMSIATA ANWLWGFLIG FFTPFITGAI NFYYGYVFMG
510 520 530 540 550
CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW VPPSRRGANY
560 570
DAEEMTHDDK PLYKRMFSTK
Length:570
Mass (Da):62,735
Last modified:February 1, 1995 - v1
Checksum:i251A2CF0F0FEB75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA Translation: CAA83497.1
U51032 Genomic DNA Translation: AAB64778.1
BK006938 Genomic DNA Translation: DAA12183.1
PIRiS43186
RefSeqiNP_010629.3, NM_001180650.3

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C
GeneIDi851943
KEGGisce:YDR342C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA Translation: CAA83497.1
U51032 Genomic DNA Translation: AAB64778.1
BK006938 Genomic DNA Translation: DAA12183.1
PIRiS43186
RefSeqiNP_010629.3, NM_001180650.3

3D structure databases

ProteinModelPortaliP39004
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32399, 57 interactors
DIPiDIP-5182N
IntActiP39004, 31 interactors
MINTiP39004
STRINGi4932.YDR342C

Protein family/group databases

TCDBi2.A.1.1.31 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP39004

Proteomic databases

MaxQBiP39004
PaxDbiP39004
PRIDEiP39004

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C
GeneIDi851943
KEGGisce:YDR342C

Organism-specific databases

SGDiS000002750 HXT7

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000202870
InParanoidiP39004
KOiK08139
OMAiAPKHYPG
OrthoDBiEOG092C1Q5W

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER

Miscellaneous databases

PROiPR:P39004

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXT7_YEAST
AccessioniPrimary (citable) accession number: P39004
Secondary accession number(s): D6VSX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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