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Protein

Copper-transporting ATPase

Gene

CCC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Copper1
Metal bindingi16Copper1
Metal bindingi91CopperPROSITE-ProRule annotation1
Metal bindingi94CopperPROSITE-ProRule annotation1
Active sitei6274-aspartylphosphate intermediateBy similarity1
Metal bindingi838MagnesiumPROSITE-ProRule annotation1
Metal bindingi842MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: SGD
  • copper ion binding Source: SGD
  • copper-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • copper ion export Source: SGD
  • copper ion transport Source: UniProtKB
  • transmembrane transport Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER
BRENDAi3.6.3.4 984
ReactomeiR-SCE-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.5.17 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.54)
Alternative name(s):
Cu(2+)-ATPase
Gene namesi
Name:CCC2
Ordered Locus Names:YDR270W
ORF Names:D9954.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002678 CCC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 262CytoplasmicSequence analysisAdd BLAST262
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 303Lumenal, vesicleSequence analysisAdd BLAST20
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 335CytoplasmicSequence analysisAdd BLAST11
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 370Lumenal, vesicleSequence analysisAdd BLAST14
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 528CytoplasmicSequence analysisAdd BLAST137
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 577Lumenal, vesicleSequence analysisAdd BLAST28
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 901CytoplasmicSequence analysisAdd BLAST303
Transmembranei902 – 924HelicalSequence analysisAdd BLAST23
Topological domaini925 – 927Lumenal, vesicleSequence analysis3
Transmembranei928 – 950HelicalSequence analysisAdd BLAST23
Topological domaini951 – 1004CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463181 – 1004Copper-transporting ATPaseAdd BLAST1004

Proteomic databases

MaxQBiP38995
PaxDbiP38995
PRIDEiP38995

PTM databases

iPTMnetiP38995

Interactioni

Protein-protein interaction databases

BioGridi32325, 72 interactors
DIPiDIP-906N
IntActiP38995, 3 interactors
MINTiP38995
STRINGi4932.YDR270W

Structurei

Secondary structure

11004
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP38995
SMRiP38995
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38995

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 68HMA 1PROSITE-ProRule annotationAdd BLAST66
Domaini81 – 147HMA 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063773
HOGENOMiHOG000250397
InParanoidiP38995
KOiK17686
OMAiHIFGGPL
OrthoDBiEOG092C0DN9

Family and domain databases

CDDicd00371 HMA, 2 hits
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 2 hits
SUPFAMiSSF55008 SSF55008, 2 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 2 hits
PS50846 HMA_2, 2 hits

Sequencei

Sequence statusi: Complete.

P38995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV
60 70 80 90 100
TADSIKEIIE DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK
110 120 130 140 150
QVEGIEGVES VVVSLVTEEC HVIYEPSKTT LETAREMIED CGFDSNIIMD
160 170 180 190 200
GNGNADMTEK TVILKVTKAF EDESPLILSS VSERFQFLLD LGVKSIEISD
210 220 230 240 250
DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT QLRLLSKEDE
260 270 280 290 300
IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF
310 320 330 340 350
YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF
360 370 380 390 400
SVFSLVHNMF HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA
410 420 430 440 450
LSKLIQLTPS VCSIISDVER NETKEIPIEL LQVNDIVEIK PGMKIPADGI
460 470 480 490 500
ITRGESEIDE SLMTGESILV PKKTGFPVIA GSVNGPGHFY FRTTTVGEET
510 520 530 540 550
KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL TFFIWCFILN
560 570 580 590 600
ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG
610 620 630 640 650
VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG
660 670 680 690 700
NVDEDEVLAC IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL
710 720 730 740 750
GKGIVSKCQV NGNTYDICIG NEALILEDAL KKSGFINSNV DQGNTVSYVS
760 770 780 790 800
VNGHVFGLFE INDEVKHDSY ATVQYLQRNG YETYMITGDN NSAAKRVARE
810 820 830 840 850
VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI NDAPALALSD
860 870 880 890 900
LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL
910 920 930 940 950
NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML
960 970 980 990 1000
KKWTPPDIES HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN

EEVL
Length:1,004
Mass (Da):109,829
Last modified:February 1, 1995 - v1
Checksum:i571E9F73EA1F599F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA Translation: AAC37425.1
U51030 Genomic DNA Translation: AAB64451.1
BK006938 Genomic DNA Translation: DAA12113.1
PIRiS55353
RefSeqiNP_010556.1, NM_001180578.1

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W
GeneIDi851862
KEGGisce:YDR270W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA Translation: AAC37425.1
U51030 Genomic DNA Translation: AAB64451.1
BK006938 Genomic DNA Translation: DAA12113.1
PIRiS55353
RefSeqiNP_010556.1, NM_001180578.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FVQNMR-A2-72[»]
1FVSNMR-A2-72[»]
1UV1model-B2-72[»]
1UV2model-B2-72[»]
2GGPNMR-B2-72[»]
ProteinModelPortaliP38995
SMRiP38995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32325, 72 interactors
DIPiDIP-906N
IntActiP38995, 3 interactors
MINTiP38995
STRINGi4932.YDR270W

Protein family/group databases

TCDBi3.A.3.5.17 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP38995

Proteomic databases

MaxQBiP38995
PaxDbiP38995
PRIDEiP38995

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W
GeneIDi851862
KEGGisce:YDR270W

Organism-specific databases

SGDiS000002678 CCC2

Phylogenomic databases

GeneTreeiENSGT00530000063773
HOGENOMiHOG000250397
InParanoidiP38995
KOiK17686
OMAiHIFGGPL
OrthoDBiEOG092C0DN9

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER
BRENDAi3.6.3.4 984
ReactomeiR-SCE-936837 Ion transport by P-type ATPases

Miscellaneous databases

EvolutionaryTraceiP38995
PROiPR:P38995

Family and domain databases

CDDicd00371 HMA, 2 hits
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 2 hits
SUPFAMiSSF55008 SSF55008, 2 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 2 hits
PS50846 HMA_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiATU2_YEAST
AccessioniPrimary (citable) accession number: P38995
Secondary accession number(s): D6VSQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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