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UniProtKB - P38988 (GGC1_YEAST)
Protein
Mitochondrial GTP/GDP carrier protein 1
Gene
GGC1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria. Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance.
2 PublicationsKineticsi
- KM=1.2 µM for GTP1 Publication
- KM=4.7 µM for GDP1 Publication
- KM=15.9 µM for dGTP1 Publication
- Vmax=2.0 mmol/min/g enzyme1 Publication
GO - Molecular functioni
GO - Biological processi
- cellular iron ion homeostasis Source: SGD
- guanine nucleotide transport Source: SGD
- mitochondrial genome maintenance Source: SGD
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.29.21.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial GTP/GDP carrier protein 1 |
Gene namesi | Name:GGC1 Synonyms:SHM1, YHM1 Ordered Locus Names:YDL198C ORF Names:D1214 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002357, GGC1 |
VEuPathDBi | FungiDB:YDL198C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 85 – 101 | Helical; Name=2Sequence analysisAdd BLAST | 17 | |
Transmembranei | 122 – 142 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 189 | Helical; Name=4Sequence analysisAdd BLAST | 17 | |
Transmembranei | 214 – 234 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 285 | Helical; Name=6Sequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090687 | 1 – 300 | Mitochondrial GTP/GDP carrier protein 1Add BLAST | 300 |
Proteomic databases
MaxQBi | P38988 |
PaxDbi | P38988 |
PRIDEi | P38988 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31848, 36 interactors |
DIPi | DIP-7756N |
IntActi | P38988, 21 interactors |
MINTi | P38988 |
STRINGi | 4932.YDL198C |
Miscellaneous databases
RNActi | P38988, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 108 | Solcar 1Add BLAST | 101 | |
Repeati | 117 – 198 | Solcar 2Add BLAST | 82 | |
Repeati | 208 – 293 | Solcar 3Add BLAST | 86 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0750, Eukaryota |
HOGENOMi | CLU_053371_0_0_1 |
InParanoidi | P38988 |
OMAi | KATFFQN |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 2 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P38988-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPHTDKKQSG LARLLGSASA GIMEIAVFHP VDTISKRLMS NHTKITSGQE
60 70 80 90 100
LNRVIFRDHF SEPLGKRLFT LFPGLGYAAS YKVLQRVYKY GGQPFANEFL
110 120 130 140 150
NKHYKKDFDN LFGEKTGKAM RSAAAGSLIG IGEIVLLPLD VLKIKRQTNP
160 170 180 190 200
ESFKGRGFIK ILRDEGLFNL YRGWGWTAAR NAPGSFALFG GNAFAKEYIL
210 220 230 240 250
GLKDYSQATW SQNFISSIVG ACSSLIVSAP LDVIKTRIQN RNFDNPESGL
260 270 280 290 300
RIVKNTLKNE GVTAFFKGLT PKLLTTGPKL VFSFALAQSL IPRFDNLLSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08352 Genomic DNA Translation: AAC49493.1 X83276 Genomic DNA Translation: CAA58249.1 X99000 Genomic DNA Translation: CAA67471.1 Z74246 Genomic DNA Translation: CAA98775.1 AY693086 Genomic DNA Translation: AAT93105.1 BK006938 Genomic DNA Translation: DAA11666.1 |
PIRi | S58779 |
RefSeqi | NP_010083.1, NM_001180258.1 |
Genome annotation databases
EnsemblFungii | YDL198C_mRNA; YDL198C; YDL198C |
GeneIDi | 851329 |
KEGGi | sce:YDL198C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08352 Genomic DNA Translation: AAC49493.1 X83276 Genomic DNA Translation: CAA58249.1 X99000 Genomic DNA Translation: CAA67471.1 Z74246 Genomic DNA Translation: CAA98775.1 AY693086 Genomic DNA Translation: AAT93105.1 BK006938 Genomic DNA Translation: DAA11666.1 |
PIRi | S58779 |
RefSeqi | NP_010083.1, NM_001180258.1 |
3D structure databases
AlphaFoldDBi | P38988 |
SASBDBi | P38988 |
SMRi | P38988 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31848, 36 interactors |
DIPi | DIP-7756N |
IntActi | P38988, 21 interactors |
MINTi | P38988 |
STRINGi | 4932.YDL198C |
Protein family/group databases
TCDBi | 2.A.29.21.1, the mitochondrial carrier (mc) family |
Proteomic databases
MaxQBi | P38988 |
PaxDbi | P38988 |
PRIDEi | P38988 |
Genome annotation databases
EnsemblFungii | YDL198C_mRNA; YDL198C; YDL198C |
GeneIDi | 851329 |
KEGGi | sce:YDL198C |
Organism-specific databases
SGDi | S000002357, GGC1 |
VEuPathDBi | FungiDB:YDL198C |
Phylogenomic databases
eggNOGi | KOG0750, Eukaryota |
HOGENOMi | CLU_053371_0_0_1 |
InParanoidi | P38988 |
OMAi | KATFFQN |
Miscellaneous databases
PROi | PR:P38988 |
RNActi | P38988, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 2 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GGC1_YEAST | |
Accessioni | P38988Primary (citable) accession number: P38988 Secondary accession number(s): D6VRF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families