Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial GTP/GDP carrier protein 1

Gene

GGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria. Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance.2 Publications

Kineticsi

  1. KM=1.2 µM for GTP1 Publication
  2. KM=4.7 µM for GDP1 Publication
  3. KM=15.9 µM for dGTP1 Publication
  1. Vmax=2.0 mmol/min/g enzyme1 Publication

GO - Molecular functioni

  • guanine nucleotide transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • guanine nucleotide transport Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • mitochondrial transport Source: GO_Central
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29582-MONOMER

Protein family/group databases

TCDBi2.A.29.21.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial GTP/GDP carrier protein 1
Gene namesi
Name:GGC1
Synonyms:SHM1, YHM1
Ordered Locus Names:YDL198C
ORF Names:D1214
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL198C
SGDiS000002357 GGC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei85 – 101Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei173 – 189Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei214 – 234Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 285Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906871 – 300Mitochondrial GTP/GDP carrier protein 1Add BLAST300

Proteomic databases

MaxQBiP38988
PaxDbiP38988
PRIDEiP38988

Interactioni

Protein-protein interaction databases

BioGridi31848, 28 interactors
DIPiDIP-7756N
IntActiP38988, 23 interactors
MINTiP38988
STRINGi4932.YDL198C

Structurei

3D structure databases

ProteinModelPortaliP38988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 108Solcar 1Add BLAST101
Repeati117 – 198Solcar 2Add BLAST82
Repeati208 – 293Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP38988
OMAiWGWTAAR
OrthoDBiEOG092C3ME7

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 2 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P38988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHTDKKQSG LARLLGSASA GIMEIAVFHP VDTISKRLMS NHTKITSGQE
60 70 80 90 100
LNRVIFRDHF SEPLGKRLFT LFPGLGYAAS YKVLQRVYKY GGQPFANEFL
110 120 130 140 150
NKHYKKDFDN LFGEKTGKAM RSAAAGSLIG IGEIVLLPLD VLKIKRQTNP
160 170 180 190 200
ESFKGRGFIK ILRDEGLFNL YRGWGWTAAR NAPGSFALFG GNAFAKEYIL
210 220 230 240 250
GLKDYSQATW SQNFISSIVG ACSSLIVSAP LDVIKTRIQN RNFDNPESGL
260 270 280 290 300
RIVKNTLKNE GVTAFFKGLT PKLLTTGPKL VFSFALAQSL IPRFDNLLSK
Length:300
Mass (Da):33,215
Last modified:February 1, 1995 - v1
Checksum:i3B0AB95EF563E85C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08352 Genomic DNA Translation: AAC49493.1
X83276 Genomic DNA Translation: CAA58249.1
X99000 Genomic DNA Translation: CAA67471.1
Z74246 Genomic DNA Translation: CAA98775.1
AY693086 Genomic DNA Translation: AAT93105.1
BK006938 Genomic DNA Translation: DAA11666.1
PIRiS58779
RefSeqiNP_010083.1, NM_001180258.1

Genome annotation databases

EnsemblFungiiYDL198C; YDL198C; YDL198C
GeneIDi851329
KEGGisce:YDL198C

Similar proteinsi

Entry informationi

Entry nameiGGC1_YEAST
AccessioniPrimary (citable) accession number: P38988
Secondary accession number(s): D6VRF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health