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Protein

40S ribosomal protein SA

Gene

sta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development.UniRule annotation1 Publication

Caution

Was originally thought to be a laminin receptor.Curated

GO - Molecular functioni

  • ribosome binding Source: UniProtKB
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Alternative name(s):
K14
Laminin receptor homolog
Protein stubaristaUniRule annotation
Gene namesi
Name:staUniRule annotation
ORF Names:CG14792
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003517 sta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001343531 – 27040S ribosomal protein SAAdd BLAST270

Proteomic databases

PaxDbiP38979
PRIDEiP38979

Expressioni

Developmental stagei

Expressed both maternally and zygotically in embryos.1 Publication

Gene expression databases

BgeeiFBgn0003517
ExpressionAtlasiP38979 baseline and differential
GenevisibleiP38979 DM

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with oho23B/rpS21.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi57663, 21 interactors
DIPiDIP-17178N
IntActiP38979, 3 interactors
MINTiP38979
STRINGi7227.FBpp0070279

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AA1-270[»]
ProteinModelPortaliP38979
SMRiP38979
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0830 Eukaryota
COG0052 LUCA
GeneTreeiENSGT00390000015036
InParanoidiP38979
KOiK02998
OMAiQQKTKDM
OrthoDBiEOG091G0J0Q
PhylomeDBiP38979

Family and domain databases

CDDicd01425 RPS2, 1 hit
HAMAPiMF_03015 Ribosomal_S2_euk, 1 hit
InterProiView protein in InterPro
IPR032281 40S_SA_C
IPR001865 Ribosomal_S2
IPR018130 Ribosomal_S2_CS
IPR027498 Ribosomal_S2_euk
IPR005707 Ribosomal_S2_euk/arc
IPR023591 Ribosomal_S2_flav_dom_sf
PANTHERiPTHR11489 PTHR11489, 1 hit
PfamiView protein in Pfam
PF16122 40S_SA_C, 1 hit
PF00318 Ribosomal_S2, 2 hits
PRINTSiPR00395 RIBOSOMALS2
SUPFAMiSSF52313 SSF52313, 1 hit
TIGRFAMsiTIGR01012 uS2_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00962 RIBOSOMAL_S2_1, 1 hit
PS00963 RIBOSOMAL_S2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGLDILSL KEDDITKMLV ATTHLGSENV NFQMEQYVYK RRADGVNILN
60 70 80 90 100
LGKTWEKLQL AARAIVAIDN PSDIFVISSR PIGQRAVLKF AKYTDTTPIA
110 120 130 140 150
GRFTPGAFTN QIQPAFREPR LLVVTDPNTD HQPIMEASYV NIPVIAFTNT
160 170 180 190 200
DSPLRYIDIA IPCNNKSAHS IGLMWWLLAR EVLRLRGTIS RSVEWPVVVD
210 220 230 240 250
LFFYRDPEEA EKEEAAAKEL LPPPKIEEAV DHPVEETTNW ADEVAAETVG
260 270
GVEDWNEDTV KTSWGSDGQF
Length:270
Mass (Da):30,228
Last modified:January 31, 2018 - v3
Checksum:iFEC452C3F1712C82
GO

Sequence cautioni

The sequence AAA28667 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90422 Genomic DNA Translation: AAA28741.1
AE014298 Genomic DNA Translation: AAF45638.2
AE014298 Genomic DNA Translation: AAN09049.1
AE014298 Genomic DNA Translation: AAN09050.3
AL031027 Genomic DNA Translation: CAA19839.1
AE014298 Genomic DNA Translation: AHN59256.1
AY118899 mRNA Translation: AAM50759.1
BT029094 mRNA Translation: ABJ17027.1
M77133 mRNA Translation: AAA28667.1 Different initiation.
PIRiT13602
RefSeqiNP_001284785.1, NM_001297856.1
NP_476750.1, NM_057402.5
NP_726744.1, NM_166889.2
NP_726745.3, NM_166890.3
UniGeneiDm.33985
Dm.4723

Genome annotation databases

EnsemblMetazoaiFBtr0070289; FBpp0070277; FBgn0003517
FBtr0070290; FBpp0070278; FBgn0003517
FBtr0339593; FBpp0308665; FBgn0003517
FBtr0339594; FBpp0308666; FBgn0003517
GeneIDi31106
KEGGidme:Dmel_CG14792

Similar proteinsi

Entry informationi

Entry nameiRSSA_DROME
AccessioniPrimary (citable) accession number: P38979
Secondary accession number(s): Q058X4
, Q7KW10, Q9W583, X2JC80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 31, 2018
Last modified: June 20, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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