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Protein

Protein transport protein SEC31

Gene

SEC31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.6 Publications

Miscellaneous

Present with 1840 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural molecule activity Source: SGD

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29580-MONOMER
ReactomeiR-SCE-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC31
Alternative name(s):
Protein WEB1
Gene namesi
Name:SEC31
Synonyms:WEB1
Ordered Locus Names:YDL195W
ORF Names:D1229
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL195W
SGDiS000002354 SEC31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514361 – 1273Protein transport protein SEC31Add BLAST1273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1
Modified residuei980PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei992PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1050PhosphothreonineCombined sources1
Modified residuei1053PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38968
PaxDbiP38968
PRIDEiP38968

PTM databases

iPTMnetiP38968

Interactioni

Subunit structurei

The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. Interacts with EMP24, ERV25, SEC16 and SHR3.9 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi31850, 232 interactors
ComplexPortaliCPX-2523 COPII vesicle coat complex
DIPiDIP-4792N
IntActiP38968, 52 interactors
MINTiP38968
STRINGi4932.YDL195W

Structurei

Secondary structure

11273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP38968
SMRiP38968
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38968

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 46WD 1Add BLAST41
Repeati60 – 99WD 2Add BLAST40
Repeati106 – 146WD 3Add BLAST41
Repeati158 – 198WD 4Add BLAST41
Repeati207 – 250WD 5Add BLAST44
Repeati255 – 295WD 6Add BLAST41
Repeati298 – 338WD 7Add BLAST41
Repeati385 – 405WD 8; interaction with SEC13Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi773 – 1149Pro-richAdd BLAST377

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000003175
HOGENOMiHOG000048339
InParanoidiP38968
KOiK14005
OMAiVSWSQAD
OrthoDBiEOG092C0AD5

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR021614 Sec31
IPR009917 SRA1-protein/COPII_Sec31
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12931 Sec16_C, 1 hit
PF11549 Sec31, 1 hit
PF07304 SRA1, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P38968-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLAEFSRT ATFAWSHDKI PLLVSGTVSG TVDANFSTDS SLELWSLLAA
60 70 80 90 100
DSEKPIASLQ VDSKFNDLDW SHNNKIIAGA LDNGSLELYS TNEANNAINS
110 120 130 140 150
MARFSNHSSS VKTVKFNAKQ DNVLASGGNN GEIFIWDMNK CTESPSNYTP
160 170 180 190 200
LTPGQSMSSV DEVISLAWNQ SLAHVFASAG SSNFASIWDL KAKKEVIHLS
210 220 230 240 250
YTSPNSGIKQ QLSVVEWHPK NSTRVATATG SDNDPSILIW DLRNANTPLQ
260 270 280 290 300
TLNQGHQKGI LSLDWCHQDE HLLLSSGRDN TVLLWNPESA EQLSQFPARG
310 320 330 340 350
NWCFKTKFAP EAPDLFACAS FDNKIEVQTL QNLTNTLDEQ ETETKQQESE
360 370 380 390 400
TDFWNNVSRE ESKEKPTVFH LQAPTWYGEP SPAAHWAFGG KLVQITPDGK
410 420 430 440 450
GVSITNPKIS GLESNTTLSE ALKTKDFKPL INQRLVKVID DVNEEDWNLL
460 470 480 490 500
EKLSMDGTEE FLKEALAFDN DESDAQDDAN NEKEDDGEEF FQQIETNFQP
510 520 530 540 550
EGDFSLSGNI EQTISKNLVS GNIKSAVKNS LENDLLMEAM VIALDSNNER
560 570 580 590 600
LKESVKNAYF AKYGSKSSLS RILYSISKRE VDDLVENLDV SQWKFISKAI
610 620 630 640 650
QNLYPNDIAQ RNEMLIKLGD RLKENGHRQD SLTLYLAAGS LDKVASIWLS
660 670 680 690 700
EFPDLEDKLK KDNKTIYEAH SECLTEFIER FTVFSNFING SSTINNEQLI
710 720 730 740 750
AKFLEFINLT TSTGNFELAT EFLNSLPSDN EEVKTEKARV LIASGKSLPA
760 770 780 790 800
QNPATATTSK AKYTNAKTNK NVPVLPTPGM PSTTSIPSMQ APFYGMTPGA
810 820 830 840 850
SANALPPKPY VPATTTSAPV HTEGKYAPPS QPSMASPFVN KTNSSTRLNS
860 870 880 890 900
FAPPPNPYAT ATVPATNVST TSIPQNTFAP IQPGMPIMGD YNAQSSSIPS
910 920 930 940 950
QPPINAVSGQ TPHLNRKAND GWNDLPLKVK EKPSRAKAVS VAPPNILSTP
960 970 980 990 1000
TPLNGIPANA ASTMPPPPLS RAPSSVSMVS PPPLHKNSRV PSLVATSESP
1010 1020 1030 1040 1050
RASISNPYAP PQSSQQFPIG TISTANQTSN TAQVASSNPY APPPQQRVAT
1060 1070 1080 1090 1100
PLSGGVPPAP LPKASNPYAP TATTQPNGSS YPPTGPYTNN HTMTSPPPVF
1110 1120 1130 1140 1150
NKPPTGPPPI SMKKRSNKLA SIEQNPSQGA TYPPTLSSSA SPLQPSQPPT
1160 1170 1180 1190 1200
LASQVNTSAE NVSHEIPADQ QPIVDFLKEE LARVTPLTPK EYSKQLKDCD
1210 1220 1230 1240 1250
KRLKILFYHL EKQDLLTQPT IDCLHDLVAL MKEKKYKEAM VIHANIATNH
1260 1270
AQEGGNWLTG VKRLIGIAEA TLN
Length:1,273
Mass (Da):138,717
Last modified:July 27, 2011 - v3
Checksum:i87F192E4B10E7571
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317A → T in AAA50367 (PubMed:7760818).Curated1
Sequence conflicti367T → S in CAA58252 (PubMed:8896272).Curated1
Sequence conflicti367T → S in CAA98772 (PubMed:9169867).Curated1
Sequence conflicti691S → N in AAA50367 (PubMed:7760818).Curated1
Sequence conflicti754A → V in AAA50367 (PubMed:7760818).Curated1
Sequence conflicti877T → A in AAA50367 (PubMed:7760818).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15219 Genomic DNA Translation: AAA50367.1
X83276 Genomic DNA Translation: CAA58252.1
Z74243 Genomic DNA Translation: CAA98772.1
BK006938 Genomic DNA Translation: DAA11668.2
PIRiS58782
RefSeqiNP_010086.2, NM_001180255.2

Genome annotation databases

EnsemblFungiiYDL195W; YDL195W; YDL195W
GeneIDi851332
KEGGisce:YDL195W

Similar proteinsi

Entry informationi

Entry nameiSEC31_YEAST
AccessioniPrimary (citable) accession number: P38968
Secondary accession number(s): D6VRF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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