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Entry version 152 (08 May 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Tryptophan permease

Gene

TAT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine.2 Publications

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33436-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.10.8 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tryptophan permease
Alternative name(s):
Tryptophan amino acid transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAT2
Synonyms:LTG3, SAB2, SCM2, TAP2
Ordered Locus Names:YOL020W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOL020W

Saccharomyces Genome Database

More...
SGDi
S000005380 TAT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 113ExtracellularSequence analysis5
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 160CytoplasmicSequence analysisAdd BLAST26
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 192ExtracellularSequence analysisAdd BLAST11
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 226CytoplasmicSequence analysisAdd BLAST13
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 266ExtracellularSequence analysisAdd BLAST19
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 306CytoplasmicSequence analysisAdd BLAST19
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 358ExtracellularSequence analysisAdd BLAST31
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 404CytoplasmicSequence analysisAdd BLAST25
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 428ExtracellularSequence analysis3
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 472CytoplasmicSequence analysisAdd BLAST23
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 514ExtracellularSequence analysisAdd BLAST21
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 592CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541601 – 592Tryptophan permeaseAdd BLAST592

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38967

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38967

PRoteomics IDEntifications database

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PRIDEi
P38967

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P38967

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P38967

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34382, 99 interactors

Database of interacting proteins

More...
DIPi
DIP-1782N

Protein interaction database and analysis system

More...
IntActi
P38967, 4 interactors

Molecular INTeraction database

More...
MINTi
P38967

STRING: functional protein association networks

More...
STRINGi
4932.YOL020W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261848

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38967

KEGG Orthology (KO)

More...
KOi
K16261

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMWLIVL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55205 SSF55205, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00913 2A0310, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38967-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEDFISSVK RSNEELKERK SNFGFVEYKS KQLTSSSSHN SNSSHHDDDN
60 70 80 90 100
QHGKRNIFQR CVDSFKSPLD GSFDTSNLKR TLKPRHLIMI AIGGSIGTGL
110 120 130 140 150
FVGSGKAIAE GGPLGVVIGW AIAGSQIIGT IHGLGEITVR FPVVGAFANY
160 170 180 190 200
GTRFLDPSIS FVVSTIYVLQ WFFVLPLEII AAAMTVQYWN SSIDPVIWVA
210 220 230 240 250
IFYAVIVSIN LFGVRGFGEA EFAFSTIKAI TVCGFIILCV VLICGGGPDH
260 270 280 290 300
EFIGAKYWHD PGCLANGFPG VLSVLVVASY SLGGIEMTCL ASGETDPKGL
310 320 330 340 350
PSAIKQVFWR ILFFFLISLT LVGFLVPYTN QNLLGGSSVD NSPFVIAIKL
360 370 380 390 400
HHIKALPSIV NAVILISVLS VGNSCIFASS RTLCSMAHQG LIPWWFGYID
410 420 430 440 450
RAGRPLVGIM ANSLFGLLAF LVKSGSMSEV FNWLMAIAGL ATCIVWLSIN
460 470 480 490 500
LSHIRFRLAM KAQGKSLDEL EFVSAVGIWG SAYSALINCL ILIAQFYCSL
510 520 530 540 550
WPIGGWTSGK ERAKIFFQNY LCALIMLFIF IVHKIYYKCQ TGKWWGVKAL
560 570 580 590
KDIDLETDRK DIDIEIVKQE IAEKKMYLDS RPWYVRQFHF WC
Length:592
Mass (Da):65,404
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA233BAD16264B319
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187Q → T in BAA03811 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79150 Genomic DNA Translation: CAA55777.1
L33461 Genomic DNA Translation: AAA60324.1
D16304 Genomic DNA Translation: BAA03811.1
U66834 Genomic DNA Translation: AAB07526.1
Z74761 Genomic DNA Translation: CAA99019.1
Z74762 Genomic DNA Translation: CAA99020.1
BK006948 Genomic DNA Translation: DAA10761.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46273

NCBI Reference Sequences

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RefSeqi
NP_014622.1, NM_001183274.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOL020W_mRNA; YOL020W_mRNA; YOL020W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOL020W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79150 Genomic DNA Translation: CAA55777.1
L33461 Genomic DNA Translation: AAA60324.1
D16304 Genomic DNA Translation: BAA03811.1
U66834 Genomic DNA Translation: AAB07526.1
Z74761 Genomic DNA Translation: CAA99019.1
Z74762 Genomic DNA Translation: CAA99020.1
BK006948 Genomic DNA Translation: DAA10761.1
PIRiS46273
RefSeqiNP_014622.1, NM_001183274.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34382, 99 interactors
DIPiDIP-1782N
IntActiP38967, 4 interactors
MINTiP38967
STRINGi4932.YOL020W

Protein family/group databases

TCDBi2.A.3.10.8 the amino acid-polyamine-organocation (apc) family

PTM databases

SwissPalmiP38967

Proteomic databases

MaxQBiP38967
PaxDbiP38967
PRIDEiP38967
TopDownProteomicsiP38967

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL020W_mRNA; YOL020W_mRNA; YOL020W
GeneIDi854139
KEGGisce:YOL020W

Organism-specific databases

EuPathDBiFungiDB:YOL020W
SGDiS000005380 TAT2

Phylogenomic databases

HOGENOMiHOG000261848
InParanoidiP38967
KOiK16261
OMAiIMWLIVL

Enzyme and pathway databases

BioCyciYEAST:G3O-33436-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38967

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAT2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38967
Secondary accession number(s): D6W245
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 8, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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