Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (07 Apr 2021)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Vacuolar protein sorting-associated protein 45

Gene

VPS45

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole.

1 Publication

Miscellaneous

Present with 5660 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS45
Synonyms:STT10, VPL28
Ordered Locus Names:YGL095C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003063, VPS45

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGL095C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002063161 – 577Vacuolar protein sorting-associated protein 45Add BLAST577

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38932

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38932

PRoteomics IDEntifications database

More...
PRIDEi
P38932

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38932

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEP7 and TLG2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33156, 164 interactors

Database of interacting proteins

More...
DIPi
DIP-2693N

Protein interaction database and analysis system

More...
IntActi
P38932, 14 interactors

Molecular INTeraction database

More...
MINTi
P38932

STRING: functional protein association networks

More...
STRINGi
4932.YGL095C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38932, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38932

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1299, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013933_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38932

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENVFTQH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1910, 1 hit
3.40.50.2060, 1 hit
3.90.830.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043154, Sec-1-like_dom1
IPR027482, Sec-1-like_dom2
IPR043127, Sec-1-like_dom3a
IPR001619, Sec1-like
IPR036045, Sec1-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11679, PTHR11679, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00995, Sec1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005715, VPS45_Sec1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56815, SSF56815, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLFDVADFY INKIVTSQSK LSVANVNEHQ RIKVLLLDKN TTPTISLCAT
60 70 80 90 100
QSELLKHEIY LVERIENEQR EVSRHLRCLV YVKPTEETLQ HLLRELRNPR
110 120 130 140 150
YGEYQIFFSN IVSKSQLERL AESDDLEAVT KVEEIFQDFF ILNQDLFSFD
160 170 180 190 200
LQPREFLSNK LVWSEGGLTK CTNSLVSVLL SLKIKPDIRY EGASKICERL
210 220 230 240 250
AKEVSYEIGK NERTFFDFPV MDSTPVLLIL DRNTDPITPL LQPWTYQSMI
260 270 280 290 300
NEYIGIKRNI VDLSKVPRID KDLEKVTLSS KQDAFFRDTM YLNFGELGDK
310 320 330 340 350
VKQYVTTYKD KTQTNSQINS IEDIKNFIEK YPEFRKLSGN VAKHMAIVGE
360 370 380 390 400
LDRQLKIKNI WEISEIEQNL SAHDANEEDF SDLIKLLQNE AVDKYYKLKL
410 420 430 440 450
ACIYSLNNQT SSDKIRQLVE ILSQQLPPED VNFFHKFKSL FSRQDKMTQS
460 470 480 490 500
NHDKDDILTE LARRFNSRMN SKSNTAENVY MQHIPEISSL LTDLSKNALF
510 520 530 540 550
RDRFKEIDTQ GHRVIGNQQS KDIPQDVILF VIGGVTYEEA RLVHDFNGTM
560 570
NNRMRVVLGG TSILSTKEYM DSIRSAK
Length:577
Mass (Da):67,017
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AA50D568228228F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136F → S in AAA79230 (PubMed:7720726).Curated1
Sequence conflicti239P → T in AAA79230 (PubMed:7720726).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07972 Genomic DNA Translation: AAA79230.1
D28953 Genomic DNA Translation: BAA06080.1
U11049 Genomic DNA Translation: AAC48980.1
Z72617 Genomic DNA Translation: CAA96801.1
BK006941 Genomic DNA Translation: DAA08011.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48542

NCBI Reference Sequences

More...
RefSeqi
NP_011420.3, NM_001180960.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL095C_mRNA; YGL095C; YGL095C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL095C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07972 Genomic DNA Translation: AAA79230.1
D28953 Genomic DNA Translation: BAA06080.1
U11049 Genomic DNA Translation: AAC48980.1
Z72617 Genomic DNA Translation: CAA96801.1
BK006941 Genomic DNA Translation: DAA08011.1
PIRiS48542
RefSeqiNP_011420.3, NM_001180960.3

3D structure databases

SMRiP38932
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33156, 164 interactors
DIPiDIP-2693N
IntActiP38932, 14 interactors
MINTiP38932
STRINGi4932.YGL095C

PTM databases

iPTMnetiP38932

Proteomic databases

MaxQBiP38932
PaxDbiP38932
PRIDEiP38932

Genome annotation databases

EnsemblFungiiYGL095C_mRNA; YGL095C; YGL095C
GeneIDi852785
KEGGisce:YGL095C

Organism-specific databases

SGDiS000003063, VPS45
VEuPathDBiFungiDB:YGL095C

Phylogenomic databases

eggNOGiKOG1299, Eukaryota
GeneTreeiENSGT00550000075028
HOGENOMiCLU_013933_3_1_1
InParanoidiP38932
OMAiENVFTQH

Enzyme and pathway databases

ReactomeiR-SCE-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38932
RNActiP38932, protein

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
3.40.50.2060, 1 hit
3.90.830.10, 1 hit
InterProiView protein in InterPro
IPR043154, Sec-1-like_dom1
IPR027482, Sec-1-like_dom2
IPR043127, Sec-1-like_dom3a
IPR001619, Sec1-like
IPR036045, Sec1-like_sf
PANTHERiPTHR11679, PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995, Sec1, 1 hit
PIRSFiPIRSF005715, VPS45_Sec1, 1 hit
SUPFAMiSSF56815, SSF56815, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS45_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38932
Secondary accession number(s): D6VU50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again