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Protein

Calcium-transporting ATPase 2

Gene

PMC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4454-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: SGD

GO - Biological processi

  • calcium ion transport Source: SGD
  • cellular calcium ion homeostasis Source: UniProtKB
  • transmembrane transport Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30530-MONOMER
ReactomeiR-SCE-418359 Reduction of cytosolic Ca++ levels
R-SCE-5578775 Ion homeostasis
R-SCE-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.2.2 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 2 (EC:3.6.3.8)
Alternative name(s):
Vacuolar Ca(2+)-ATPase
Gene namesi
Name:PMC1
Ordered Locus Names:YGL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL006W
SGDiS000002974 PMC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 114CytoplasmicSequence analysisAdd BLAST114
Transmembranei115 – 139HelicalSequence analysisAdd BLAST25
Topological domaini140 – 152ExtracellularSequence analysisAdd BLAST13
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 349CytoplasmicSequence analysisAdd BLAST176
Transmembranei350 – 368HelicalSequence analysisAdd BLAST19
Topological domaini369 – 388ExtracellularSequence analysisAdd BLAST20
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 899CytoplasmicSequence analysisAdd BLAST490
Transmembranei900 – 922HelicalSequence analysisAdd BLAST23
Topological domaini923 – 929ExtracellularSequence analysis7
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Topological domaini951 – 976CytoplasmicSequence analysisAdd BLAST26
Transmembranei977 – 998HelicalSequence analysisAdd BLAST22
Topological domaini999 – 1010ExtracellularSequence analysisAdd BLAST12
Transmembranei1011 – 1029HelicalSequence analysisAdd BLAST19
Topological domaini1030 – 1065CytoplasmicSequence analysisAdd BLAST36
Transmembranei1066 – 1086HelicalSequence analysisAdd BLAST21
Topological domaini1087 – 1099ExtracellularSequence analysisAdd BLAST13
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21
Topological domaini1121 – 1173CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462321 – 1173Calcium-transporting ATPase 2Add BLAST1173

Proteomic databases

MaxQBiP38929
PaxDbiP38929
PRIDEiP38929

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FTH1P383103EBI-3097,EBI-20959

Protein-protein interaction databases

BioGridi33239, 82 interactors
DIPiDIP-5901N
IntActiP38929, 38 interactors
MINTiP38929
STRINGi4932.YGL006W

Structurei

3D structure databases

ProteinModelPortaliP38929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000046331
HOGENOMiHOG000265623
InParanoidiP38929
KOiK01537
OMAiSNPIFCT
OrthoDBiEOG092C12IX

Family and domain databases

InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P38929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQDENSAL LANNENNKPS YTGNENGVYD NFKLSKSQLS DLHNPKSIRS
60 70 80 90 100
FVRLFGYESN SLFKYLKTDK NAGISLPEIS NYRKTNRYKN YGDNSLPERI
110 120 130 140 150
PKSFLQLVWA AFNDKTMQLL TVAAVVSFVL GLYELWMQPP QYDPEGNKIK
160 170 180 190 200
QVDWIEGVAI MIAVFVVVLV SAANDYQKEL QFAKLNKKKE NRKIIVIRND
210 220 230 240 250
QEILISIHHV LVGDVISLQT GDVVPADCVM ISGKCEADES SITGESNTIQ
260 270 280 290 300
KFPVDNSLRD FKKFNSIDSH NHSKPLDIGD VNEDGNKIAD CMLISGSRIL
310 320 330 340 350
SGLGRGVITS VGINSVYGQT MTSLNAEPES TPLQLHLSQL ADNISVYGCV
360 370 380 390 400
SAIILFLVLF TRYLFYIIPE DGRFHDLDPA QKGSKFMNIF ITSITVIVVA
410 420 430 440 450
VPEGLPLAVT LALAFATTRM TKDGNLVRVL RSCETMGSAT AVCSDKTGTL
460 470 480 490 500
TENVMTVVRG FPGNSKFDDS KSLPVSEQRK LNSKKVFEEN CSSSLRNDLL
510 520 530 540 550
ANIVLNSTAF ENRDYKKNDK NTNGSKNMSK NLSFLDKCKS RLSFFKKGNR
560 570 580 590 600
EDDEDQLFKN VNKGRQEPFI GSKTETALLS LARLSLGLQP GELQYLRDQP
610 620 630 640 650
MEKFNIEKVV QTIPFESSRK WAGLVVKYKE GKNKKPFYRF FIKGAAEIVS
660 670 680 690 700
KNCSYKRNSD DTLEEINEDN KKETDDEIKN LASDALRAIS VAHKDFCECD
710 720 730 740 750
SWPPEQLRDK DSPNIAALDL LFNSQKGLIL DGLLGIQDPL RAGVRESVQQ
760 770 780 790 800
CQRAGVTVRM VTGDNILTAK AIARNCAILS TDISSEAYSA MEGTEFRKLT
810 820 830 840 850
KNERIRILPN LRVLARSSPE DKRLLVETLK GMGDVVAVTG DGTNDAPALK
860 870 880 890 900
LADVGFSMGI SGTEVAREAS DIILMTDDFS AIVNAIKWGR CVSVSIKKFI
910 920 930 940 950
QFQLIVNITA VILTFVSSVA SSDETSVLTA VQLLWINLIM DTLAALALAT
960 970 980 990 1000
DKPDPNIMDR KPRGRSTSLI SVSTWKMILS QATLQLIVTF ILHFYGPELF
1010 1020 1030 1040 1050
FKKHEDEITS HQQQQLNAMT FNTFVWLQFF TMLVSRKLDE GDGISNWRGR
1060 1070 1080 1090 1100
ISAANLNFFQ DLGRNYYFLT IMAIIGSCQV LIMFFGGAPF SIARQTKSMW
1110 1120 1130 1140 1150
ITAVLCGMLS LIMGVLVRIC PDEVAVKVFP AAFVQRFKYV FGLEFLRKNH
1160 1170
TGKHDDEEAL LEESDSPEST AFY
Length:1,173
Mass (Da):130,861
Last modified:February 1, 1995 - v1
Checksum:i5BD9ECFF8508F396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03060 Unassigned DNA Translation: AAC48919.1
Z72528 Genomic DNA Translation: CAA96706.1
BK006941 Genomic DNA Translation: DAA08093.1
PIRiS48877
RefSeqiNP_011509.1, NM_001180871.1

Genome annotation databases

EnsemblFungiiYGL006W; YGL006W; YGL006W
GeneIDi852878
KEGGisce:YGL006W

Similar proteinsi

Entry informationi

Entry nameiATC2_YEAST
AccessioniPrimary (citable) accession number: P38929
Secondary accession number(s): D6VUD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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