UniProtKB - P38919 (IF4A3_HUMAN)
Eukaryotic initiation factor 4A-III
EIF4A3
Functioni
Catalytic activityi
- EC:3.6.4.133 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 60 | ATP; via carbonyl oxygenCombined sources4 Publications | 1 | |
Binding sitei | 65 | ATPCombined sources4 Publications | 1 | |
Binding sitei | 342 | ATPCombined sources4 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 85 – 90 | ATPCombined sources4 Publications | 6 | |
Nucleotide bindingi | 367 – 371 | ATPCombined sources4 Publications | 5 |
GO - Molecular functioni
- ATP binding Source: HGNC-UCL
- mRNA binding Source: UniProtKB
- poly(A) binding Source: HGNC-UCL
- ribonucleoprotein complex binding Source: Ensembl
- RNA binding Source: UniProtKB
- RNA helicase activity Source: HGNC-UCL
- RNA stem-loop binding Source: Ensembl
- selenocysteine insertion sequence binding Source: Ensembl
- translation regulator activity Source: Ensembl
GO - Biological processi
- associative learning Source: Ensembl
- cellular response to brain-derived neurotrophic factor stimulus Source: Ensembl
- cellular response to selenite ion Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: UniProtKB
- exploration behavior Source: Ensembl
- mRNA 3'-end processing Source: Reactome
- mRNA export from nucleus Source: Reactome
- mRNA splicing, via spliceosome Source: UniProtKB
- negative regulation of excitatory postsynaptic potential Source: Ensembl
- negative regulation of selenocysteine incorporation Source: Ensembl
- negative regulation of selenocysteine insertion sequence binding Source: Ensembl
- negative regulation of translation Source: HGNC-UCL
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
- positive regulation of translation Source: UniProtKB
- regulation of translation at postsynapse, modulating synaptic transmission Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- RNA export from nucleus Source: Reactome
- rRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, rRNA processing, Translation regulation, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.4.13, 2681 |
PathwayCommonsi | P38919 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-429947, Deadenylation of mRNA R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Protein family/group databases
TCDBi | 3.A.18.1.1, the nuclear mrna exporter (mrna-e) family |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic initiation factor 4A-III (EC:3.6.4.133 Publications)Short name: eIF-4A-III Short name: eIF4A-III Alternative name(s): ATP-dependent RNA helicase DDX48 ATP-dependent RNA helicase eIF4A-3 DEAD box protein 48 Eukaryotic initiation factor 4A-like NUK-34 Eukaryotic translation initiation factor 4A isoform 3 Nuclear matrix protein 265 Short name: NMP 265 Short name: hNMP 265 Cleaved into the following chain: |
Gene namesi | Name:EIF4A3 Synonyms:DDX48, KIAA0111 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18683, EIF4A3 |
MIMi | 608546, gene |
neXtProti | NX_P38919 |
VEuPathDBi | HostDB:ENSG00000141543.9 |
Subcellular locationi
Nucleus
- Nucleus 6 Publications
- Nucleus speckle 1 Publication
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity).By similarity
Cytosol
- cytosol Source: Reactome
- postsynaptic cytosol Source: Ensembl
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- exon-exon junction complex Source: UniProtKB
- nuclear speck Source: UniProtKB-SubCell
- nucleolus Source: GO_Central
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- U2-type catalytic step 1 spliceosome Source: UniProtKB
Other locations
- cytoplasm Source: HGNC-UCL
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePathology & Biotechi
Involvement in diseasei
Richieri-Costa-Pereira syndrome (RCPS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071090 | 270 | D → G in RCPS. 1 PublicationCorresponds to variant dbSNP:rs587777204EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 88 | K → A: ATPase activity is not increased by the presence of CASC3. Does not prevent EJC formation. Prevents the EJC disassembly. 1 Publication | 1 | |
Mutagenesisi | 99 | C → Q: No effect on interaction with CWC22. 1 Publication | 1 | |
Mutagenesisi | 270 | D → K: Loss of CWC22-binding and loss of incorporation into EJCs; when associated with K-273. 1 Publication | 1 | |
Mutagenesisi | 273 | D → K: Loss of CWC22-binding and loss of incorporation into EJCs; when associated with K-270. 1 Publication | 1 | |
Mutagenesisi | 276 – 277 | TI → GD: Loss of CWC22-binding and loss of incorporation into EJCs. 1 Publication | 2 | |
Mutagenesisi | 300 – 301 | AN → RD: Decreased interaction with CWC22. 1 Publication | 2 | |
Mutagenesisi | 301 – 303 | NFT → LAG: Loss of CWC22-binding and loss of incorporation into EJCs. 1 Publication | 3 | |
Mutagenesisi | 334 | T → V: Reduced incorporation into EJCs. 1 Publication | 1 | |
Mutagenesisi | 401 | D → K: Loss of incorporation into EJCs; when associated with R-402. 1 Publication | 1 | |
Mutagenesisi | 402 | E → R: Loss of incorporation into EJCs; when associated with K-401. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 9775 |
MalaCardsi | EIF4A3 |
MIMi | 268305, phenotype |
OpenTargetsi | ENSG00000141543 |
Orphaneti | 3102, Richieri Costa-Pereira syndrome |
PharmGKBi | PA162384945 |
Miscellaneous databases
Pharosi | P38919, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105832 |
Genetic variation databases
BioMutai | EIF4A3 |
DMDMi | 20532400 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423267 | 1 – 411 | Eukaryotic initiation factor 4A-IIIAdd BLAST | 411 | |
Initiator methioninei | Removed; alternateCombined sources1 Publication | |||
ChainiPRO_0000054942 | 2 – 411 | Eukaryotic initiation factor 4A-III, N-terminally processedAdd BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylalanine; in Eukaryotic initiation factor 4A-III, N-terminally processedCombined sources1 Publication | 1 | |
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Cross-linki | 19 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 124 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 152 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 163 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 198 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 296 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 314 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 321 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 374 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 382 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P38919 |
jPOSTi | P38919 |
MassIVEi | P38919 |
MaxQBi | P38919 |
PaxDbi | P38919 |
PeptideAtlasi | P38919 |
PRIDEi | P38919 |
ProteomicsDBi | 55305 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00009328 |
PTM databases
iPTMneti | P38919 |
PhosphoSitePlusi | P38919 |
SwissPalmi | P38919 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000141543, Expressed in right adrenal gland and 247 other tissues |
ExpressionAtlasi | P38919, baseline and differential |
Genevisiblei | P38919, HS |
Organism-specific databases
HPAi | ENSG00000141543, Low tissue specificity |
Interactioni
Subunit structurei
Identified in the spliceosome C complex (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29301961). Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A (PubMed:15034551, PubMed:14730019, PubMed:16170325, PubMed:16314458, PubMed:23917022, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275).
Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4 (PubMed:14730019, PubMed:16170325, PubMed:16495234, PubMed:22961380). May interact with NOM1.
Interacts with POLDIP3 (PubMed:18423201).
Interacts with CWC22 and PRPF19 in an RNA-independent manner (PubMed:22959432, PubMed:22961380, PubMed:23236153, PubMed:24218557). Direct interaction with CWC22 is mediated by the helicase C-terminal domain (PubMed:22959432, PubMed:24218557). Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA.
Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro) (PubMed:20479275).
Interacts with NCBP3 (PubMed:26382858).
Interacts with NRDE2 (PubMed:30538148).
21 PublicationsBinary interactionsi
Hide detailsP38919
Protein-protein interaction databases
BioGRIDi | 115119, 406 interactors |
ComplexPortali | CPX-1941, Exon junction core complex, MAGOH variant CPX-682, Exon junction core complex, MAGOHB variant |
CORUMi | P38919 |
DIPi | DIP-33218N |
IntActi | P38919, 204 interactors |
MINTi | P38919 |
STRINGi | 9606.ENSP00000269349 |
Chemistry databases
BindingDBi | P38919 |
Miscellaneous databases
RNActi | P38919, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P38919 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38919 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 239 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 171 | |
Domaini | 250 – 411 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 162 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 38 – 66 | Q motifAdd BLAST | 29 | |
Motifi | 187 – 190 | DEAD boxCurated | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0328, Eukaryota |
GeneTreei | ENSGT00940000155037 |
HOGENOMi | CLU_003041_1_0_1 |
InParanoidi | P38919 |
OMAi | RAANFTV |
OrthoDBi | 726081at2759 |
PhylomeDBi | P38919 |
TreeFami | TF300466 |
Family and domain databases
DisProti | DP02069 |
IDEALi | IID00370 |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL
60 70 80 90 100
RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL
110 120 130 140 150
DIQVRETQAL ILAPTRELAV QIQKGLLALG DYMNVQCHAC IGGTNVGEDI
160 170 180 190 200
RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA IKMLVLDEAD EMLNKGFKEQ
210 220 230 240 250
IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL VKRDELTLEG
260 270 280 290 300
IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA
310 320 330 340 350
NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII
360 370 380 390 400
NYDLPNNREL YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI
410
DEMPMNVADL I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L3H2 | I3L3H2_HUMAN | RNA helicase | EIF4A3 | 390 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 210 | P → S in CAA56074 (Ref. 1) Curated | 1 | |
Sequence conflicti | 370 | R → Q in CAA56074 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071090 | 270 | D → G in RCPS. 1 PublicationCorresponds to variant dbSNP:rs587777204EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79538 mRNA Translation: CAA56074.1 D21853 mRNA Translation: BAA04879.2 Different initiation. AK290608 mRNA Translation: BAF83297.1 CR456750 mRNA Translation: CAG33031.1 AC087741 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89584.1 BC003662 mRNA Translation: AAH03662.1 BC004386 mRNA Translation: AAH04386.1 BC011151 mRNA Translation: AAH11151.1 |
CCDSi | CCDS11767.1 |
PIRi | S45142 |
RefSeqi | NP_055555.1, NM_014740.3 |
Genome annotation databases
Ensembli | ENST00000647795; ENSP00000497661; ENSG00000141543 ENST00000649764; ENSP00000497641; ENSG00000141543 |
GeneIDi | 9775 |
KEGGi | hsa:9775 |
UCSCi | uc002jxs.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79538 mRNA Translation: CAA56074.1 D21853 mRNA Translation: BAA04879.2 Different initiation. AK290608 mRNA Translation: BAF83297.1 CR456750 mRNA Translation: CAG33031.1 AC087741 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89584.1 BC003662 mRNA Translation: AAH03662.1 BC004386 mRNA Translation: AAH04386.1 BC011151 mRNA Translation: AAH11151.1 |
CCDSi | CCDS11767.1 |
PIRi | S45142 |
RefSeqi | NP_055555.1, NM_014740.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HXY | X-ray | 3.30 | A/B/C/D | 23-411 | [»] | |
2HYI | X-ray | 2.30 | C/I | 1-411 | [»] | |
2J0Q | X-ray | 3.20 | A/B | 2-411 | [»] | |
2J0S | X-ray | 2.21 | A | 2-411 | [»] | |
2J0U | X-ray | 3.00 | A/B | 38-411 | [»] | |
2XB2 | X-ray | 3.40 | A/X | 1-411 | [»] | |
3EX7 | X-ray | 2.30 | C/H | 1-411 | [»] | |
4C9B | X-ray | 2.00 | A | 1-411 | [»] | |
5MQF | electron microscopy | 5.90 | p | 1-411 | [»] | |
5XJC | electron microscopy | 3.60 | u | 1-411 | [»] | |
5YZG | electron microscopy | 4.10 | u | 1-411 | [»] | |
6ICZ | electron microscopy | 3.00 | u | 1-411 | [»] | |
6QDV | electron microscopy | 3.30 | 7 | 22-404 | [»] | |
6YVH | X-ray | 3.19 | H/J/K/L | 246-411 | [»] | |
7A5P | electron microscopy | 5.00 | y | 1-411 | [»] | |
SMRi | P38919 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115119, 406 interactors |
ComplexPortali | CPX-1941, Exon junction core complex, MAGOH variant CPX-682, Exon junction core complex, MAGOHB variant |
CORUMi | P38919 |
DIPi | DIP-33218N |
IntActi | P38919, 204 interactors |
MINTi | P38919 |
STRINGi | 9606.ENSP00000269349 |
Chemistry databases
BindingDBi | P38919 |
ChEMBLi | CHEMBL4105832 |
Protein family/group databases
TCDBi | 3.A.18.1.1, the nuclear mrna exporter (mrna-e) family |
PTM databases
iPTMneti | P38919 |
PhosphoSitePlusi | P38919 |
SwissPalmi | P38919 |
Genetic variation databases
BioMutai | EIF4A3 |
DMDMi | 20532400 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00009328 |
Proteomic databases
EPDi | P38919 |
jPOSTi | P38919 |
MassIVEi | P38919 |
MaxQBi | P38919 |
PaxDbi | P38919 |
PeptideAtlasi | P38919 |
PRIDEi | P38919 |
ProteomicsDBi | 55305 |
Protocols and materials databases
Antibodypediai | 19760, 234 antibodies |
DNASUi | 9775 |
Genome annotation databases
Ensembli | ENST00000647795; ENSP00000497661; ENSG00000141543 ENST00000649764; ENSP00000497641; ENSG00000141543 |
GeneIDi | 9775 |
KEGGi | hsa:9775 |
UCSCi | uc002jxs.3, human |
Organism-specific databases
CTDi | 9775 |
DisGeNETi | 9775 |
GeneCardsi | EIF4A3 |
HGNCi | HGNC:18683, EIF4A3 |
HPAi | ENSG00000141543, Low tissue specificity |
MalaCardsi | EIF4A3 |
MIMi | 268305, phenotype 608546, gene |
neXtProti | NX_P38919 |
OpenTargetsi | ENSG00000141543 |
Orphaneti | 3102, Richieri Costa-Pereira syndrome |
PharmGKBi | PA162384945 |
VEuPathDBi | HostDB:ENSG00000141543.9 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0328, Eukaryota |
GeneTreei | ENSGT00940000155037 |
HOGENOMi | CLU_003041_1_0_1 |
InParanoidi | P38919 |
OMAi | RAANFTV |
OrthoDBi | 726081at2759 |
PhylomeDBi | P38919 |
TreeFami | TF300466 |
Enzyme and pathway databases
BRENDAi | 3.6.4.13, 2681 |
PathwayCommonsi | P38919 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-429947, Deadenylation of mRNA R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 9775, 797 hits in 967 CRISPR screens |
ChiTaRSi | EIF4A3, human |
EvolutionaryTracei | P38919 |
GeneWikii | EIF4A3 |
GenomeRNAii | 9775 |
Pharosi | P38919, Tbio |
PROi | PR:P38919 |
RNActi | P38919, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141543, Expressed in right adrenal gland and 247 other tissues |
ExpressionAtlasi | P38919, baseline and differential |
Genevisiblei | P38919, HS |
Family and domain databases
DisProti | DP02069 |
IDEALi | IID00370 |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IF4A3_HUMAN | |
Accessioni | P38919Primary (citable) accession number: P38919 Secondary accession number(s): Q15033, Q6IBQ2, Q96A18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 236 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families