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Protein

10 kDa heat shock protein, mitochondrial

Gene

HSP10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ATP binding Source: InterPro
  • chaperone binding Source: SGD
  • metal ion binding Source: GO_Central
  • unfolded protein binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33568-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
HSP10
Alternative name(s):
10 kDa chaperonin
Gene namesi
Name:HSP10
Synonyms:CPN10
Ordered Locus Names:YOR020C
ORF Names:OR26.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR020C
SGDiS000005546 HSP10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001749222 – 10610 kDa heat shock protein, mitochondrialAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei31PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP38910
PaxDbiP38910
PRIDEiP38910
TopDownProteomicsiP38910

PTM databases

iPTMnetiP38910

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34424, 501 interactors
DIPiDIP-1483N
IntActiP38910, 9 interactors
MINTiP38910
STRINGi4932.YOR020C

Structurei

3D structure databases

ProteinModelPortaliP38910
SMRiP38910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006350
HOGENOMiHOG000133897
InParanoidiP38910
KOiK04078
OMAiPGRIDDN
OrthoDBiEOG092C5N2T

Family and domain databases

CDDicd00320 cpn10, 1 hit
Gene3Di2.30.33.40, 1 hit
HAMAPiMF_00580 CH10, 1 hit
InterProiView protein in InterPro
IPR020818 Chaperonin_GroES
IPR037124 Chaperonin_GroES_sf
IPR018369 Chaprnonin_Cpn10_CS
IPR011032 GroES-like_sf
PANTHERiPTHR10772 PTHR10772, 1 hit
PfamiView protein in Pfam
PF00166 Cpn10, 1 hit
PRINTSiPR00297 CHAPERONIN10
SMARTiView protein in SMART
SM00883 Cpn10, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
PROSITEiView protein in PROSITE
PS00681 CHAPERONINS_CPN10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLLKSAKS IVPLMDRVLV QRIKAQAKTA SGLYLPEKNV EKLNQAEVVA
60 70 80 90 100
VGPGFTDANG NKVVPQVKVG DQVLIPQFGG STIKLGNDDE VILFRDAEIL

AKIAKD
Length:106
Mass (Da):11,372
Last modified:February 1, 1995 - v1
Checksum:i0453269D502C05E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82T → S in AAT93241 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76853 Genomic DNA Translation: CAA54185.1
X75754 Genomic DNA Translation: CAA53382.1
X87331 Genomic DNA Translation: CAA60769.1
Z74928 Genomic DNA Translation: CAA99210.1
AY693222 Genomic DNA Translation: AAT93241.1
BK006948 Genomic DNA Translation: DAA10802.1
PIRiS39463
RefSeqiNP_014663.1, NM_001183439.1

Genome annotation databases

EnsemblFungiiYOR020C; YOR020C; YOR020C
GeneIDi854185
KEGGisce:YOR020C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76853 Genomic DNA Translation: CAA54185.1
X75754 Genomic DNA Translation: CAA53382.1
X87331 Genomic DNA Translation: CAA60769.1
Z74928 Genomic DNA Translation: CAA99210.1
AY693222 Genomic DNA Translation: AAT93241.1
BK006948 Genomic DNA Translation: DAA10802.1
PIRiS39463
RefSeqiNP_014663.1, NM_001183439.1

3D structure databases

ProteinModelPortaliP38910
SMRiP38910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34424, 501 interactors
DIPiDIP-1483N
IntActiP38910, 9 interactors
MINTiP38910
STRINGi4932.YOR020C

PTM databases

iPTMnetiP38910

Proteomic databases

MaxQBiP38910
PaxDbiP38910
PRIDEiP38910
TopDownProteomicsiP38910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR020C; YOR020C; YOR020C
GeneIDi854185
KEGGisce:YOR020C

Organism-specific databases

EuPathDBiFungiDB:YOR020C
SGDiS000005546 HSP10

Phylogenomic databases

GeneTreeiENSGT00390000006350
HOGENOMiHOG000133897
InParanoidiP38910
KOiK04078
OMAiPGRIDDN
OrthoDBiEOG092C5N2T

Enzyme and pathway databases

BioCyciYEAST:G3O-33568-MONOMER

Miscellaneous databases

PROiPR:P38910

Family and domain databases

CDDicd00320 cpn10, 1 hit
Gene3Di2.30.33.40, 1 hit
HAMAPiMF_00580 CH10, 1 hit
InterProiView protein in InterPro
IPR020818 Chaperonin_GroES
IPR037124 Chaperonin_GroES_sf
IPR018369 Chaprnonin_Cpn10_CS
IPR011032 GroES-like_sf
PANTHERiPTHR10772 PTHR10772, 1 hit
PfamiView protein in Pfam
PF00166 Cpn10, 1 hit
PRINTSiPR00297 CHAPERONIN10
SMARTiView protein in SMART
SM00883 Cpn10, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
PROSITEiView protein in PROSITE
PS00681 CHAPERONINS_CPN10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_YEAST
AccessioniPrimary (citable) accession number: P38910
Secondary accession number(s): D6W286, E9P935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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