Inner kinetochore subunit CHL4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• structural molecule activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.7

    "Chl4p and Iml3p are two new members of the budding yeast outer kinetochore."
    Pot I., Measday V., Snydsman B., Cagney G., Fields S., Davis T.N., Muller E.G.D., Hieter P.
    Mol. Biol. Cell 14:460-476(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH CTF3; CTF19 AND IML3, SUBCELLULAR LOCATION.
  • "Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae."
    Mythreye K., Bloom K.S.
    J Cell Biol 160:833-843(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell division Source: UniProtKB-KW
• chromosome segregation Source: SGDInferred from mutant phenotypeⁱ
  • Ref.2

    "Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast."
    Kouprina N.Y., Kirillov A.V., Kroll E.S., Koryabin M.Y., Shestopalov B., Bannikov V.M., Zakharyev V.M., Larionov V.L.
    Genetics 135:327-341(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
  • Ref.5

    "The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome."
    Roy N., Poddar A., Lohia A., Sinha P.
    Curr. Genet. 32:182-189(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• establishment of meiotic sister chromatid cohesion Source: SGDInferred from mutant phenotypeⁱ
  • "Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3."
    Fernius J., Marston A.L.
    PLoS Genet 5:e1000629-e1000629(2009) [PubMed] [Europe PMC] [Abstract]
• establishment of mitotic sister chromatid cohesion Source: SGDInferred from mutant phenotypeⁱ
  • "Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3."
    Fernius J., Marston A.L.
    PLoS Genet 5:e1000629-e1000629(2009) [PubMed] [Europe PMC] [Abstract]
• kinetochore assembly Source: SGDInferred from mutant phenotypeⁱ
  • "Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae."
    Mythreye K., Bloom K.S.
    J Cell Biol 160:833-843(2003) [PubMed] [Europe PMC] [Abstract]
• maintenance of meiotic sister chromatid cohesion Source: SGDInferred from mutant phenotypeⁱ
  • "A genome-wide screen identifies genes required for centromeric cohesion."
    Marston A.L., Tham W.-H., Shah H., Amon A.
    Science 303:1367-1370(2004) [PubMed] [Europe PMC] [Abstract]
• mitotic spindle assembly checkpoint Source: SGDInferred from mutant phenotypeⁱ
  • "A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint."
    Matson D.R., Demirel P.B., Stukenberg P.T., Burke D.J.
    Genes Dev 26:542-547(2012) [PubMed] [Europe PMC] [Abstract]
• protein localization to chromosome, centromeric region Source: SGDInferred from mutant phenotypeⁱ
  • "The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I."
    Kiburz B.M., Reynolds D.B., Megee P.C., Marston A.L., Lee B.H., Lee T.I., Levine S.S., Young R.A., Amon A.
    Genes Dev 19:3017-3030(2005) [PubMed] [Europe PMC] [Abstract]
  • "The kinetochore prevents centromere-proximal crossover recombination during meiosis."
    Vincenten N., Kuhl L.M., Lam I., Oke A., Kerr A.R., Hochwagen A., Fung J., Keeney S., Vader G., Marston A.L.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSNELRLEDN YVPTSDTLVV FKQLMKLPVT VLYDLTLSWF AKFGGSFDGD 
        60         70         80         90        100
IYLLTETLDL LIEKGVRRNV IVNRILYVYW PDGLNVFQLA EIDCHLMISK 
       110        120        130        140        150
PEKFKWLPSK ALRGDGKPYV VKLQPAKFIE NLQTDLAKIY HCHVYMFKHP 
       160        170        180        190        200
SLPVLITRIQ LFDSNNLFLS TPNIGSINKE SLYNKLDKFQ GKPLISRRPY 
       210        220        230        240        250
YVAFPLNSPI IFHSVDKDIY ARLVLQSISR TISERETIIF KPVQKIPVKS 
       260        270        280        290        300
IHNIMTLLGP SRFAESMGPW ECYASANFER SPLHDYKKHQ GLTGKKVMVR 
       310        320        330        340        350
EFDDSFLNDD ENFYGKEEPE IRRLRLEKNM IKFKGSANGV MDQKYNDLKE 
       360        370        380        390        400
FNEHVHNIRN GKKNEDSGEP VYISRYSSLV PIEKVGFTLK NEINSRIITI 
       410        420        430        440        450
KLKFNGNDIF GGLHELCDKN LINIDKVPGW LAGENGSFSG TIMNGDFQRE 

QVAKGGLL                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome IV
   Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families