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Entry version 139 (13 Feb 2019)
Sequence version 2 (21 Dec 2004)
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Protein

Protein SPP41

Gene

SPP41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of PRP3 and PRP4 genes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • negative regulation of gene expression Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-29992-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SPP41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPP41
Ordered Locus Names:YDR464W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR464W

Saccharomyces Genome Database

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SGDi
S000002872 SPP41

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721471 – 1435Protein SPP41Add BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki981Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1014PhosphoserineCombined sources1
Modified residuei1067PhosphoserineCombined sources1
Cross-linki1154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38904

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38904

PRoteomics IDEntifications database

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PRIDEi
P38904

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38904

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRP8 and RAP1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
32518, 284 interactors

Database of interacting proteins

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DIPi
DIP-2331N

STRING: functional protein association networks

More...
STRINGi
4932.YDR464W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P38904

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini171 – 190UIMPROSITE-ProRule annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi683 – 699Nuclear localization signalSequence analysisAdd BLAST17

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38904

Identification of Orthologs from Complete Genome Data

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OMAi
QIMQNAM

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021386 DUF3020
IPR009071 HMG_box_dom
IPR003903 UIM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11223 DUF3020, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS50330 UIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38904-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYDEDDGEI NFNELVGNLL SSHNQEGQEE GEVQGGEQEG DDFEKIYPTS
60 70 80 90 100
ENIEPKHPDD SQHMHNSPDQ NIEIPHFVDE EDELVSVVAN AVQNIDDEQA
110 120 130 140 150
KPENHLENGS EHVTSDTADD NHEKEQQQEW AHILQQEILK SDGEPLRENT
160 170 180 190 200
ERRVSTSQHH PSQRTDDALD QDDENLRMAI LESLQELNTN EEEEKEPEKH
210 220 230 240 250
EHAAPNDKLS SKKSSKKKKK DKSKNRESSK DKSSKKSKSS SHSKKHAKDR
260 270 280 290 300
NKEKQSKPTN NENTLDLSNI LENLIHENDN AAIDTAKQTV DIQDNSHTDN
310 320 330 340 350
TNNEDVEAQA LVEATLKAFE NELLSSAPTE EPSQEQSIGP VSSRKAVEPP
360 370 380 390 400
RKPTADDIPL AMLQAFKPKK RPPQEKKKTK SKTSKAASTA NKSPASESTS
410 420 430 440 450
KKKKKKKTVK ESNKSQEAYE DDEFSRILAD MVNQVVNTSL KETSTHTATQ
460 470 480 490 500
DNKLESESDF TSPVQSQYTT EDASTANDDS LDLNQIMQNA MAMVFQNQND
510 520 530 540 550
DEFDENIVED FNRGLGDLSV SDLLPHDNLS RMEKKSVPKS SSKSEKKTAI
560 570 580 590 600
SRRASKKASR DASSVELTEV PSKPKKPSKT EVSLEKKLRK KYVSIANEAA
610 620 630 640 650
SVARKKRWAK NKELKEKEKL ERQTAREERR HKKKLEKQRL AEEQEELKKI
660 670 680 690 700
VERGPPYPPD LRLTKSGKPK KPYRRWTPEE LLKRSQEAEK PRKVKKERKK
710 720 730 740 750
KEKKMKVPSS ALKKIPLFNF VKGNVQPSAR HRLNDIEGSL STIGLHKSPD
760 770 780 790 800
GVRRILSRPK SEDHEWPLSD SSASQNYDAH LKTVVHKEKI PFHPPWTIPS
810 820 830 840 850
QPPFALPVAR RKKIPNIKKY RKRTNNSFRV SKEGTASTRN RILPAILLPI
860 870 880 890 900
INTLKAAAKS QTAAGATPEE ARKRLATIIQ HAKSTVIRAA LQARKNSMQA
910 920 930 940 950
AHSKGTTTEL ATTASRMKNP LKMIPIFNTS RVKQQLDKQL PARSAGTEIS
960 970 980 990 1000
SSESPDKATP DPHSNSTIAG HTLKGVTTPI KIEDSDANVP PVSIAVSTIE
1010 1020 1030 1040 1050
PSQDKLELTK RAESVEPVEN NVETAKETQS VQEIKENVGT KASEEVTLTE
1060 1070 1080 1090 1100
DKTNGDPKNE KRILIESPVE KTDKKKPGEK IATDLNEDAS LSDKKDGDEK
1110 1120 1130 1140 1150
STLHSDAAQL TGNEPDSVNT TTGKPKLIDV SLKPLNEAKP KIPIIFPLKR
1160 1170 1180 1190 1200
PQIKPEVSVI NLVQNLVNTK IPEIKNESVD LGSNITDILS STITNILPEI
1210 1220 1230 1240 1250
TATDVKNYQY EDENVKYLKK TPRQVLNLDG LVPPSGRCIT KAKRVRRIKK
1260 1270 1280 1290 1300
LSADATTAPE ADGKANSESI TYTFDIPSPE EVQSKRSVVL KFAKARLTEA
1310 1320 1330 1340 1350
ELSCLKKEIN NVRKRRWREM NSTKNWEYDV KSRLKKRANA FFGEGESETK
1360 1370 1380 1390 1400
SKWIEERFQE KVSQEKYKDR LETTETQANN TKIVIDDKEI LNILAVNMNN
1410 1420 1430
LNKARCIEKD IQESFREEKL ASLQPKKKRK KSILH
Length:1,435
Mass (Da):161,597
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C18CF349FD647E8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA20494 differs from that shown. Reason: Frameshift at positions 1395 and 1401.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03673 Genomic DNA Translation: AAA20494.1 Frameshift.
U33050 Genomic DNA Translation: AAB64901.1
BK006938 Genomic DNA Translation: DAA12299.1

Protein sequence database of the Protein Information Resource

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PIRi
S69632

NCBI Reference Sequences

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RefSeqi
NP_010752.3, NM_001180772.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR464W_mRNA; YDR464W_mRNA; YDR464W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR464W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03673 Genomic DNA Translation: AAA20494.1 Frameshift.
U33050 Genomic DNA Translation: AAB64901.1
BK006938 Genomic DNA Translation: DAA12299.1
PIRiS69632
RefSeqiNP_010752.3, NM_001180772.3

3D structure databases

ProteinModelPortaliP38904
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32518, 284 interactors
DIPiDIP-2331N
STRINGi4932.YDR464W

PTM databases

iPTMnetiP38904

Proteomic databases

MaxQBiP38904
PaxDbiP38904
PRIDEiP38904

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR464W_mRNA; YDR464W_mRNA; YDR464W
GeneIDi852075
KEGGisce:YDR464W

Organism-specific databases

EuPathDBiFungiDB:YDR464W
SGDiS000002872 SPP41

Phylogenomic databases

InParanoidiP38904
OMAiQIMQNAM

Enzyme and pathway databases

BioCyciYEAST:G3O-29992-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38904

Family and domain databases

InterProiView protein in InterPro
IPR021386 DUF3020
IPR009071 HMG_box_dom
IPR003903 UIM_dom
PfamiView protein in Pfam
PF11223 DUF3020, 2 hits
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS50330 UIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP41_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38904
Secondary accession number(s): D6VT89, Q03291
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: February 13, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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