UniProtKB - P38902 (RPB11_YEAST)
Protein
DNA-directed RNA polymerase II subunit RPB11
Gene
RPB11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination.1 Publication
Miscellaneous
Present with 4280 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA binding Source: InterPro
- protein dimerization activity Source: InterPro
- RNA polymerase II activity Source: InterPro
GO - Biological processi
- termination of RNA polymerase II transcription Source: SGD
- transcription, RNA-templated Source: GOC
- transcription by RNA polymerase II Source: SGD
Keywordsi
Biological process | Transcription |
Enzyme and pathway databases
Reactomei | R-SCE-113418, Formation of the Early Elongation Complex R-SCE-674695, RNA Polymerase II Pre-transcription Events R-SCE-6781823, Formation of TC-NER Pre-Incision Complex R-SCE-6782135, Dual incision in TC-NER R-SCE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-SCE-6796648, TP53 Regulates Transcription of DNA Repair Genes R-SCE-6807505, RNA polymerase II transcribes snRNA genes R-SCE-72086, mRNA Capping R-SCE-73776, RNA Polymerase II Promoter Escape R-SCE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SCE-75953, RNA Polymerase II Transcription Initiation R-SCE-75955, RNA Polymerase II Transcription Elongation R-SCE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-SCE-77075, RNA Pol II CTD phosphorylation and interaction with CE R-SCE-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase II subunit RPB11Short name: RNA polymerase II subunit B11 Alternative name(s): B13.6 DNA-directed RNA polymerase II 13.6 kDa polypeptide |
Gene namesi | Name:RPB11 Ordered Locus Names:YOL005C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOL005C |
SGDi | S000005365, RPB11 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | E → G or V: Transcript termination readthrough. 1 Publication | 1 | |
Mutagenesisi | 108 | E → K: Transcript termination readthrough. Lethal. 1 Publication | 1 | |
Mutagenesisi | 111 | L → P: Transcript termination readthrough. 1 Publication | 1 | |
Mutagenesisi | 114 | L → P: Transcript termination readthrough. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149315 | 1 – 120 | DNA-directed RNA polymerase II subunit RPB11Add BLAST | 120 |
Proteomic databases
MaxQBi | P38902 |
PaxDbi | P38902 |
PRIDEi | P38902 |
PTM databases
iPTMneti | P38902 |
Interactioni
Subunit structurei
Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
3 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 34399, 390 interactors |
ComplexPortali | CPX-2662, DNA-directed RNA polymerase II complex |
DIPi | DIP-937N |
IntActi | P38902, 21 interactors |
MINTi | P38902 |
STRINGi | 4932.YOL005C |
Miscellaneous databases
RNActi | P38902, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P38902 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38902 |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.Curated
Phylogenomic databases
eggNOGi | KOG4392, Eukaryota |
HOGENOMi | CLU_090381_2_1_1 |
InParanoidi | P38902 |
OMAi | HKFVLRI |
Family and domain databases
CDDi | cd06926, RNAP_II_RPB11, 1 hit |
Gene3Di | 3.30.1360.10, 1 hit |
InterProi | View protein in InterPro IPR037685, RBP11 IPR036603, RBP11-like IPR009025, RBP11-like_dimer IPR008193, RNA_pol_Rpb11_13-16kDa_CS |
Pfami | View protein in Pfam PF13656, RNA_pol_L_2, 1 hit |
SUPFAMi | SSF55257, SSF55257, 1 hit |
PROSITEi | View protein in PROSITE PS01154, RNA_POL_L_13KD, 1 hit |
i Sequence
Sequence statusi: Complete.
P38902-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAPDRFELF LLGEGESKLK IDPDTKAPNA VVITFEKEDH TLGNLIRAEL
60 70 80 90 100
LNDRKVLFAA YKVEHPFFAR FKLRIQTTEG YDPKDALKNA CNSIINKLGA
110 120
LKTNFETEWN LQTLAADDAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62624 Genomic DNA Translation: AAB27135.1 Z74747 Genomic DNA Translation: CAA99004.1 AY557998 Genomic DNA Translation: AAS56324.1 BK006948 Genomic DNA Translation: DAA10778.1 |
PIRi | S58933 |
RefSeqi | NP_014638.1, NM_001183259.1 |
Genome annotation databases
EnsemblFungii | YOL005C_mRNA; YOL005C; YOL005C |
GeneIDi | 854157 |
KEGGi | sce:YOL005C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62624 Genomic DNA Translation: AAB27135.1 Z74747 Genomic DNA Translation: CAA99004.1 AY557998 Genomic DNA Translation: AAS56324.1 BK006948 Genomic DNA Translation: DAA10778.1 |
PIRi | S58933 |
RefSeqi | NP_014638.1, NM_001183259.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I3Q | X-ray | 3.10 | K | 1-120 | [»] | |
1I50 | X-ray | 2.80 | K | 1-120 | [»] | |
1I6H | X-ray | 3.30 | K | 1-120 | [»] | |
1K83 | X-ray | 2.80 | K | 1-120 | [»] | |
1NIK | X-ray | 4.10 | K | 1-120 | [»] | |
1NT9 | X-ray | 4.20 | K | 1-120 | [»] | |
1PQV | X-ray | 3.80 | K | 1-120 | [»] | |
1R5U | X-ray | 4.50 | K | 1-120 | [»] | |
1R9S | X-ray | 4.25 | K | 1-120 | [»] | |
1R9T | X-ray | 3.50 | K | 1-120 | [»] | |
1SFO | X-ray | 3.61 | K | 1-120 | [»] | |
1TWA | X-ray | 3.20 | K | 1-120 | [»] | |
1TWC | X-ray | 3.00 | K | 1-120 | [»] | |
1TWF | X-ray | 2.30 | K | 1-120 | [»] | |
1TWG | X-ray | 3.30 | K | 1-120 | [»] | |
1TWH | X-ray | 3.40 | K | 1-120 | [»] | |
1WCM | X-ray | 3.80 | K | 1-120 | [»] | |
1Y1V | X-ray | 3.80 | K | 1-120 | [»] | |
1Y1W | X-ray | 4.00 | K | 1-120 | [»] | |
1Y1Y | X-ray | 4.00 | K | 1-120 | [»] | |
1Y77 | X-ray | 4.50 | K | 1-120 | [»] | |
2B63 | X-ray | 3.80 | K | 1-120 | [»] | |
2B8K | X-ray | 4.15 | K | 1-120 | [»] | |
2E2H | X-ray | 3.95 | K | 1-120 | [»] | |
2E2I | X-ray | 3.41 | K | 1-120 | [»] | |
2E2J | X-ray | 3.50 | K | 1-120 | [»] | |
2JA5 | X-ray | 3.80 | K | 1-120 | [»] | |
2JA6 | X-ray | 4.00 | K | 1-120 | [»] | |
2JA7 | X-ray | 3.80 | K/W | 1-120 | [»] | |
2JA8 | X-ray | 3.80 | K | 1-120 | [»] | |
2NVQ | X-ray | 2.90 | K | 1-120 | [»] | |
2NVT | X-ray | 3.36 | K | 1-120 | [»] | |
2NVX | X-ray | 3.60 | K | 1-120 | [»] | |
2NVY | X-ray | 3.40 | K | 1-120 | [»] | |
2NVZ | X-ray | 4.30 | K | 1-120 | [»] | |
2R7Z | X-ray | 3.80 | K | 1-120 | [»] | |
2R92 | X-ray | 3.80 | K | 1-120 | [»] | |
2R93 | X-ray | 4.00 | K | 1-120 | [»] | |
2VUM | X-ray | 3.40 | K | 1-120 | [»] | |
2YU9 | X-ray | 3.40 | K | 1-120 | [»] | |
3CQZ | X-ray | 2.80 | K | 1-120 | [»] | |
3FKI | X-ray | 3.88 | K | 1-120 | [»] | |
3GTG | X-ray | 3.78 | K | 1-120 | [»] | |
3GTJ | X-ray | 3.42 | K | 1-120 | [»] | |
3GTK | X-ray | 3.80 | K | 1-120 | [»] | |
3GTL | X-ray | 3.38 | K | 1-120 | [»] | |
3GTM | X-ray | 3.80 | K | 1-120 | [»] | |
3GTO | X-ray | 4.00 | K | 1-120 | [»] | |
3GTP | X-ray | 3.90 | K | 1-120 | [»] | |
3GTQ | X-ray | 3.80 | K | 1-120 | [»] | |
3H3V | X-ray | 4.00 | L | 1-120 | [»] | |
3HOU | X-ray | 3.20 | K/W | 1-120 | [»] | |
3HOV | X-ray | 3.50 | K | 1-120 | [»] | |
3HOW | X-ray | 3.60 | K | 1-120 | [»] | |
3HOX | X-ray | 3.65 | K | 1-120 | [»] | |
3HOY | X-ray | 3.40 | K | 1-120 | [»] | |
3HOZ | X-ray | 3.65 | K | 1-120 | [»] | |
3I4M | X-ray | 3.70 | K | 1-120 | [»] | |
3I4N | X-ray | 3.90 | K | 1-120 | [»] | |
3J0K | electron microscopy | 36.00 | K | 1-120 | [»] | |
3J1N | electron microscopy | 16.00 | K | 1-120 | [»] | |
3K1F | X-ray | 4.30 | K | 1-120 | [»] | |
3K7A | X-ray | 3.80 | K | 1-120 | [»] | |
3M3Y | X-ray | 3.18 | K | 1-120 | [»] | |
3M4O | X-ray | 3.57 | K | 1-120 | [»] | |
3PO2 | X-ray | 3.30 | K | 1-120 | [»] | |
3PO3 | X-ray | 3.30 | K | 1-120 | [»] | |
3QT1 | X-ray | 4.30 | K | 1-120 | [»] | |
3RZD | X-ray | 3.30 | K | 1-120 | [»] | |
3RZO | X-ray | 3.00 | K | 1-120 | [»] | |
3S14 | X-ray | 2.85 | K | 1-120 | [»] | |
3S15 | X-ray | 3.30 | K | 1-120 | [»] | |
3S16 | X-ray | 3.24 | K | 1-120 | [»] | |
3S17 | X-ray | 3.20 | K | 1-120 | [»] | |
3S1M | X-ray | 3.13 | K | 1-120 | [»] | |
3S1N | X-ray | 3.10 | K | 1-120 | [»] | |
3S1Q | X-ray | 3.30 | K | 1-120 | [»] | |
3S1R | X-ray | 3.20 | K | 1-120 | [»] | |
3S2D | X-ray | 3.20 | K | 1-120 | [»] | |
3S2H | X-ray | 3.30 | K | 1-120 | [»] | |
4A3B | X-ray | 3.50 | K | 1-120 | [»] | |
4A3C | X-ray | 3.50 | K | 1-120 | [»] | |
4A3D | X-ray | 3.40 | K | 1-120 | [»] | |
4A3E | X-ray | 3.40 | K | 1-120 | [»] | |
4A3F | X-ray | 3.50 | K | 1-120 | [»] | |
4A3G | X-ray | 3.50 | K | 1-120 | [»] | |
4A3I | X-ray | 3.80 | K | 1-120 | [»] | |
4A3J | X-ray | 3.70 | K | 1-120 | [»] | |
4A3K | X-ray | 3.50 | K | 1-120 | [»] | |
4A3L | X-ray | 3.50 | K | 1-120 | [»] | |
4A3M | X-ray | 3.90 | K | 1-120 | [»] | |
4A93 | X-ray | 3.40 | K | 1-120 | [»] | |
4BBR | X-ray | 3.40 | K | 1-120 | [»] | |
4BBS | X-ray | 3.60 | K | 1-120 | [»] | |
4BXX | X-ray | 3.28 | K | 1-120 | [»] | |
4BXZ | X-ray | 4.80 | K | 1-120 | [»] | |
4BY1 | X-ray | 3.60 | K | 1-120 | [»] | |
4BY7 | X-ray | 3.15 | K | 1-120 | [»] | |
4V1M | electron microscopy | 6.60 | K | 1-120 | [»] | |
4V1N | electron microscopy | 7.80 | K | 1-120 | [»] | |
4V1O | electron microscopy | 9.70 | K | 1-120 | [»] | |
4X67 | X-ray | 4.10 | K | 1-120 | [»] | |
4X6A | X-ray | 3.96 | K | 1-120 | [»] | |
4Y52 | X-ray | 3.50 | K | 1-120 | [»] | |
4Y7N | X-ray | 3.30 | K | 1-120 | [»] | |
5C3E | X-ray | 3.70 | K | 1-120 | [»] | |
5C44 | X-ray | 3.95 | K | 1-120 | [»] | |
5C4A | X-ray | 4.20 | K | 1-120 | [»] | |
5C4J | X-ray | 4.00 | K | 1-120 | [»] | |
5C4X | X-ray | 4.00 | K | 1-120 | [»] | |
5FMF | electron microscopy | 6.00 | K | 1-115 | [»] | |
5FYW | electron microscopy | 4.35 | K | 1-120 | [»] | |
5FZ5 | electron microscopy | 8.80 | K | 1-120 | [»] | |
5IP7 | X-ray | 3.52 | K | 1-115 | [»] | |
5IP9 | X-ray | 3.90 | K | 1-115 | [»] | |
5OQJ | electron microscopy | 4.70 | K | 1-120 | [»] | |
5OQM | electron microscopy | 5.80 | K | 1-120 | [»] | |
5OT2 | X-ray | 3.20 | K | 1-120 | [»] | |
5SVA | electron microscopy | 15.30 | K | 1-120 | [»] | |
5U5Q | X-ray | 3.80 | K | 1-120 | [»] | |
5VVR | electron microscopy | 5.80 | K | 1-120 | [»] | |
5VVS | electron microscopy | 6.40 | K | 1-120 | [»] | |
5W4U | X-ray | 3.60 | K | 1-120 | [»] | |
5W51 | X-ray | 3.40 | K | 1-120 | [»] | |
6BLO | X-ray | 3.40 | K | 1-120 | [»] | |
6BLP | X-ray | 3.20 | K | 1-120 | [»] | |
6BM2 | X-ray | 3.40 | K | 1-120 | [»] | |
6BM4 | X-ray | 2.95 | K | 1-120 | [»] | |
6BQF | X-ray | 3.35 | K | 1-120 | [»] | |
6GYK | electron microscopy | 5.10 | K | 1-120 | [»] | |
6GYL | electron microscopy | 4.80 | K | 1-120 | [»] | |
6GYM | electron microscopy | 6.70 | K | 1-120 | [»] | |
6I84 | electron microscopy | 4.40 | K | 1-120 | [»] | |
6O6C | electron microscopy | 3.10 | I | 1-120 | [»] | |
6UPX | X-ray | 3.40 | K | 1-120 | [»] | |
6UPY | X-ray | 3.40 | K | 1-120 | [»] | |
6UPZ | X-ray | 3.10 | K | 1-120 | [»] | |
6UQ0 | X-ray | 3.56 | K | 1-120 | [»] | |
6UQ1 | X-ray | 3.60 | K | 1-120 | [»] | |
6UQ2 | X-ray | 3.20 | K | 1-120 | [»] | |
6UQ3 | X-ray | 3.47 | K | 1-120 | [»] | |
SMRi | P38902 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34399, 390 interactors |
ComplexPortali | CPX-2662, DNA-directed RNA polymerase II complex |
DIPi | DIP-937N |
IntActi | P38902, 21 interactors |
MINTi | P38902 |
STRINGi | 4932.YOL005C |
PTM databases
iPTMneti | P38902 |
Proteomic databases
MaxQBi | P38902 |
PaxDbi | P38902 |
PRIDEi | P38902 |
Genome annotation databases
EnsemblFungii | YOL005C_mRNA; YOL005C; YOL005C |
GeneIDi | 854157 |
KEGGi | sce:YOL005C |
Organism-specific databases
EuPathDBi | FungiDB:YOL005C |
SGDi | S000005365, RPB11 |
Phylogenomic databases
eggNOGi | KOG4392, Eukaryota |
HOGENOMi | CLU_090381_2_1_1 |
InParanoidi | P38902 |
OMAi | HKFVLRI |
Enzyme and pathway databases
Reactomei | R-SCE-113418, Formation of the Early Elongation Complex R-SCE-674695, RNA Polymerase II Pre-transcription Events R-SCE-6781823, Formation of TC-NER Pre-Incision Complex R-SCE-6782135, Dual incision in TC-NER R-SCE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-SCE-6796648, TP53 Regulates Transcription of DNA Repair Genes R-SCE-6807505, RNA polymerase II transcribes snRNA genes R-SCE-72086, mRNA Capping R-SCE-73776, RNA Polymerase II Promoter Escape R-SCE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SCE-75953, RNA Polymerase II Transcription Initiation R-SCE-75955, RNA Polymerase II Transcription Elongation R-SCE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-SCE-77075, RNA Pol II CTD phosphorylation and interaction with CE R-SCE-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
EvolutionaryTracei | P38902 |
PROi | PR:P38902 |
RNActi | P38902, protein |
Family and domain databases
CDDi | cd06926, RNAP_II_RPB11, 1 hit |
Gene3Di | 3.30.1360.10, 1 hit |
InterProi | View protein in InterPro IPR037685, RBP11 IPR036603, RBP11-like IPR009025, RBP11-like_dimer IPR008193, RNA_pol_Rpb11_13-16kDa_CS |
Pfami | View protein in Pfam PF13656, RNA_pol_L_2, 1 hit |
SUPFAMi | SSF55257, SSF55257, 1 hit |
PROSITEi | View protein in PROSITE PS01154, RNA_POL_L_13KD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPB11_YEAST | |
Accessioni | P38902Primary (citable) accession number: P38902 Secondary accession number(s): D6W262 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD