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Protein

DNA-directed RNA polymerase II subunit RPB11

Gene

RPB11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination.1 Publication

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • termination of RNA polymerase II transcription Source: SGD
  • transcription, RNA-templated Source: GOC
  • transcription by RNA polymerase II Source: SGD

Keywordsi

Biological processTranscription

Enzyme and pathway databases

BioCyciYEAST:G3O-33422-MONOMER
ReactomeiR-SCE-113418 Formation of the Early Elongation Complex
R-SCE-674695 RNA Polymerase II Pre-transcription Events
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SCE-6807505 RNA polymerase II transcribes snRNA genes
R-SCE-72086 mRNA Capping
R-SCE-72165 mRNA Splicing - Minor Pathway
R-SCE-73776 RNA Polymerase II Promoter Escape
R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953 RNA Polymerase II Transcription Initiation
R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-SCE-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11
Short name:
RNA polymerase II subunit B11
Alternative name(s):
B13.6
DNA-directed RNA polymerase II 13.6 kDa polypeptide
Gene namesi
Name:RPB11
Ordered Locus Names:YOL005C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL005C
SGDiS000005365 RPB11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi108E → G or V: Transcript termination readthrough. 1 Publication1
Mutagenesisi108E → K: Transcript termination readthrough. Lethal. 1 Publication1
Mutagenesisi111L → P: Transcript termination readthrough. 1 Publication1
Mutagenesisi114L → P: Transcript termination readthrough. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493151 – 120DNA-directed RNA polymerase II subunit RPB11Add BLAST120

Proteomic databases

MaxQBiP38902
PaxDbiP38902
PRIDEiP38902

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34399, 388 interactors
ComplexPortaliCPX-2662 DNA-directed RNA polymerase II complex
DIPiDIP-937N
IntActiP38902, 34 interactors
MINTiP38902
STRINGi4932.YOL005C

Structurei

Secondary structure

1120
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi18 – 20Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi25 – 27Combined sources3
Beta strandi30 – 37Combined sources8
Helixi40 – 50Combined sources11
Beta strandi56 – 62Combined sources7
Beta strandi66 – 68Combined sources3
Beta strandi70 – 77Combined sources8
Helixi83 – 108Combined sources26
Turni109 – 111Combined sources3

3D structure databases

ProteinModelPortaliP38902
SMRiP38902
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38902

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074975
HOGENOMiHOG000179862
InParanoidiP38902
KOiK03008
OMAiMAGYKIA
OrthoDBiEOG092C5QHE

Family and domain databases

CDDicd06926 RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685 RBP11
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit

Sequencei

Sequence statusi: Complete.

P38902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPDRFELF LLGEGESKLK IDPDTKAPNA VVITFEKEDH TLGNLIRAEL
60 70 80 90 100
LNDRKVLFAA YKVEHPFFAR FKLRIQTTEG YDPKDALKNA CNSIINKLGA
110 120
LKTNFETEWN LQTLAADDAF
Length:120
Mass (Da):13,616
Last modified:February 1, 1995 - v1
Checksum:iA98D109C5FF8E356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62624 Genomic DNA Translation: AAB27135.1
Z74747 Genomic DNA Translation: CAA99004.1
AY557998 Genomic DNA Translation: AAS56324.1
BK006948 Genomic DNA Translation: DAA10778.1
PIRiS58933
RefSeqiNP_014638.1, NM_001183259.1

Genome annotation databases

EnsemblFungiiYOL005C; YOL005C; YOL005C
GeneIDi854157
KEGGisce:YOL005C

Similar proteinsi

Entry informationi

Entry nameiRPB11_YEAST
AccessioniPrimary (citable) accession number: P38902
Secondary accession number(s): D6W262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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