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UniProtKB - P38865 (CTR2_YEAST)
Protein
Copper transport protein CTR2
Gene
CTR2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.
1 PublicationGO - Molecular functioni
- copper ion transmembrane transporter activity Source: SGD
GO - Biological processi
- cellular copper ion homeostasis Source: SGD
- copper ion import Source: SGD
- protein maturation by copper ion transfer Source: SGD
Keywordsi
Biological process | Copper transport, Ion transport, Transport |
Ligand | Copper |
Enzyme and pathway databases
Reactomei | R-SCE-425410, Metal ion SLC transporters |
Protein family/group databases
TCDBi | 1.A.56.1.3, the copper transporter (ctr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Copper transport protein CTR2Short name: Copper transporter 2 |
Gene namesi | Name:CTR2 Ordered Locus Names:YHR175W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001218, CTR2 |
VEuPathDBi | FungiDB:YHR175W |
Subcellular locationi
Vacuole
- Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 81 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 142 | VacuolarSequence analysisAdd BLAST | 40 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 189 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195046 | 1 – 189 | Copper transport protein CTR2Add BLAST | 189 |
Proteomic databases
PaxDbi | P38865 |
PRIDEi | P38865 |
Interactioni
Subunit structurei
Homomultimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 36608, 38 interactors |
DIPi | DIP-4763N |
IntActi | P38865, 5 interactors |
MINTi | P38865 |
STRINGi | 4932.YHR175W |
Miscellaneous databases
RNActi | P38865, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3386, Eukaryota |
HOGENOMi | CLU_079690_4_0_1 |
InParanoidi | P38865 |
OMAi | YWLCLAV |
Family and domain databases
InterProi | View protein in InterPro IPR007274, Cop_transporter |
PANTHERi | PTHR12483, PTHR12483, 1 hit |
Pfami | View protein in Pfam PF04145, Ctr, 2 hits |
i Sequence
Sequence statusi: Complete.
P38865-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM
60 70 80 90 100
GDGDDTCSMN MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE
110 120 130 140 150
YLKYCVHKRQ LSQRVLLPNR SLTKINQADK VSNSILYGLQ VGFSFMLMLV
160 170 180
FMTYNGWLML AVVCGAIWGN YSWCTSYSPE IDDSSLACH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00027 Genomic DNA Translation: AAB68020.1 BK006934 Genomic DNA Translation: DAA06867.1 |
PIRi | S48914 |
RefSeqi | NP_012045.3, NM_001179306.3 |
Genome annotation databases
EnsemblFungii | YHR175W_mRNA; YHR175W; YHR175W |
GeneIDi | 856580 |
KEGGi | sce:YHR175W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00027 Genomic DNA Translation: AAB68020.1 BK006934 Genomic DNA Translation: DAA06867.1 |
PIRi | S48914 |
RefSeqi | NP_012045.3, NM_001179306.3 |
3D structure databases
SMRi | P38865 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36608, 38 interactors |
DIPi | DIP-4763N |
IntActi | P38865, 5 interactors |
MINTi | P38865 |
STRINGi | 4932.YHR175W |
Protein family/group databases
TCDBi | 1.A.56.1.3, the copper transporter (ctr) family |
Proteomic databases
PaxDbi | P38865 |
PRIDEi | P38865 |
Genome annotation databases
EnsemblFungii | YHR175W_mRNA; YHR175W; YHR175W |
GeneIDi | 856580 |
KEGGi | sce:YHR175W |
Organism-specific databases
SGDi | S000001218, CTR2 |
VEuPathDBi | FungiDB:YHR175W |
Phylogenomic databases
eggNOGi | KOG3386, Eukaryota |
HOGENOMi | CLU_079690_4_0_1 |
InParanoidi | P38865 |
OMAi | YWLCLAV |
Enzyme and pathway databases
Reactomei | R-SCE-425410, Metal ion SLC transporters |
Miscellaneous databases
PROi | PR:P38865 |
RNActi | P38865, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007274, Cop_transporter |
PANTHERi | PTHR12483, PTHR12483, 1 hit |
Pfami | View protein in Pfam PF04145, Ctr, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR2_YEAST | |
Accessioni | P38865Primary (citable) accession number: P38865 Secondary accession number(s): D3DLC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families