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Entry version 185 (10 Feb 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Kelch repeat-containing protein 1

Gene

KEL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway.

Miscellaneous

Present with 1350 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KEL1
Ordered Locus Names:YHR158C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001201, KEL1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YHR158C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190961 – 1164Kelch repeat-containing protein 1Add BLAST1164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Modified residuei477PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei604PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei837PhosphoserineCombined sources1
Modified residuei848PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei997PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38853

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38853

PRoteomics IDEntifications database

More...
PRIDEi
P38853

2D gel databases

2-DE database at Universidad Complutense de Madrid

More...
COMPLUYEAST-2DPAGEi
P38853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38853

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KEL2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36592, 224 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-36, Kelch-containing Formin Regulatory Complex

Database of interacting proteins

More...
DIPi
DIP-1403N

Protein interaction database and analysis system

More...
IntActi
P38853, 33 interactors

Molecular INTeraction database

More...
MINTi
P38853

STRING: functional protein association networks

More...
STRINGi
4932.YHR158C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38853, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38853

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati139 – 186Kelch 1Add BLAST48
Repeati253 – 307Kelch 2Add BLAST55
Repeati308 – 357Kelch 3Add BLAST50
Repeati359 – 409Kelch 4Add BLAST51
Repeati411 – 460Kelch 5Add BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili777 – 931Sequence analysisAdd BLAST155
Coiled coili974 – 1163Sequence analysisAdd BLAST190

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0379, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005472_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38853

Identification of Orthologs from Complete Genome Data

More...
OMAi
THKVNKE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015915, Kelch-typ_b-propeller

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGFSFAKKF THKKHGKTPS DASISDQSRE ASLSTPPNEK FFTKQETPQK
60 70 80 90 100
GRQFSQGYHS NVNKTSSPPM FARKQVSESR IQPSAVPPQQ RNVSGPSTTL
110 120 130 140 150
HKQLSKQREY TVWNRIKLQN SPFPRYRHVA SAYVTDKNQI YVIGGLHDQS
160 170 180 190 200
VYGDTWILTA FDNATRFSTT TIDISEATPP PRVGHAAVLC GNAFVVFGGD
210 220 230 240 250
THKVNKEGLM DDDIYLLNIN SYKWTVPAPV GPRPLGRYGH KISIIATTQM
260 270 280 290 300
KTKLYVFGGQ FDDTYFNDLA VYDLSSFRRP DSHWEFLKPR TFTPPPITNF
310 320 330 340 350
TMISYDSKLW VFGGDTLQGL VNDVFMYDPA INDWFIIDTT GEKPPPVQEH
360 370 380 390 400
ATVVYNDLMC VVGGKDEHDA YLNSVYFLNL KSRKWFKLPV FTAGIPQGRS
410 420 430 440 450
GHSLTLLKND KILIMGGDKF DYARVEEYDL HTSDIDMQRG TIVYTLDLAR
460 470 480 490 500
IKDLCPGVMD VPTDTPTPRN GNLDLATPVT PTSHQTKNMN VPISAAPLAS
510 520 530 540 550
APSPAPKDFS DADRLNREVH NRNVSTEHQN QSHPVNSESH LIAEPNILTP
560 570 580 590 600
YVPSESSQTP VMKITSNKPF DTPTIQKEPD LSETMDPTVG NQRIPSSIYG
610 620 630 640 650
DNLTPANQIK NNSPILETLP SNEIKTPQNG NIEEIKHLPD ADEKIDSTTT
660 670 680 690 700
FDQEINGDKL GTSSMSKVEE DGNVADEDDE IGVAQMASSP SKDQFKIKHY
710 720 730 740 750
NESSELSQNN TEIDKLSEPV DITIKKSDTA GHDSANHVID ASDEKNVSPM
760 770 780 790 800
GDVPTDTKNE EASVPINRDA TTEVVDRALF EKLRSELQSL KELTHEKALE
810 820 830 840 850
AGAHIKELET ELWQLKSQKN SGTTKEIDEL DSVRLQSKCE ILEADNHSLE
860 870 880 890 900
DKVNELEELV NSKFLDIENL NEVIQFQNEK IKSLELEPNY KEKLEELQIE
910 920 930 940 950
HENLSRENER LKNESKQHNE DIINNVANYS SQLGSLISHW KENRANSSFL
960 970 980 990 1000
ESSSSLISVS DENGEKTVGE PYGDQSRHHR VVINKLTNRL DDLLERSQEL
1010 1020 1030 1040 1050
TISKEKLSSE YHALKMEHSS LSQDVLVKEN EIKKIQNDYK ESISSMDSAS
1060 1070 1080 1090 1100
KALMVSQREL EKYKSLNKKL IDELDELKFK NGVCSENFEN GLRSTEESSN
1110 1120 1130 1140 1150
NVKNSNSIRE NQFNIKINDL KAELFITNQE RDDLKSEVLE LKKRLLNLEN
1160
NTKQVNEDAD SDLL
Length:1,164
Mass (Da):131,094
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43D0FC570F1D5E4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti447D → A in AAT92822 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10397 Genomic DNA Translation: AAB68991.1
AY692803 Genomic DNA Translation: AAT92822.1
BK006934 Genomic DNA Translation: DAA06851.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46769

NCBI Reference Sequences

More...
RefSeqi
NP_012028.1, NM_001179289.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHR158C_mRNA; YHR158C; YHR158C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856563

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHR158C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA Translation: AAB68991.1
AY692803 Genomic DNA Translation: AAT92822.1
BK006934 Genomic DNA Translation: DAA06851.1
PIRiS46769
RefSeqiNP_012028.1, NM_001179289.1

3D structure databases

SMRiP38853
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36592, 224 interactors
ComplexPortaliCPX-36, Kelch-containing Formin Regulatory Complex
DIPiDIP-1403N
IntActiP38853, 33 interactors
MINTiP38853
STRINGi4932.YHR158C

PTM databases

iPTMnetiP38853

2D gel databases

COMPLUYEAST-2DPAGEiP38853

Proteomic databases

MaxQBiP38853
PaxDbiP38853
PRIDEiP38853

Genome annotation databases

EnsemblFungiiYHR158C_mRNA; YHR158C; YHR158C
GeneIDi856563
KEGGisce:YHR158C

Organism-specific databases

SGDiS000001201, KEL1
VEuPathDBiFungiDB:YHR158C

Phylogenomic databases

eggNOGiKOG0379, Eukaryota
GeneTreeiENSGT00940000176597
HOGENOMiCLU_005472_0_0_1
InParanoidiP38853
OMAiTHKVNKE

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38853
RNActiP38853, protein

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915, Kelch-typ_b-propeller
SUPFAMiSSF117281, SSF117281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKEL1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38853
Secondary accession number(s): D3DLA7, E9P8X4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 10, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
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