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UniProtKB - P38845 (CRP1_YEAST)
Protein
Cruciform DNA-recognizing protein 1
Gene
CRP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Cruciform DNA-binding protein which exerts an enhancing effect on the cleavage of cruciform DNA (X-DNA) by endonuclease VII from bacteriophage T4.
1 PublicationMiscellaneous
Present with 2990 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA binding Source: SGD
- protein kinase binding Source: GO_Central
GO - Biological processi
- regulation of primary metabolic process Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-SCE-1632852, Macroautophagy R-SCE-163680, AMPK inhibits chREBP transcriptional activation activity R-SCE-200425, Carnitine metabolism R-SCE-380972, Energy dependent regulation of mTOR by LKB1-AMPK |
Names & Taxonomyi
Protein namesi | Recommended name: Cruciform DNA-recognizing protein 1Cleaved into the following 2 chains: |
Gene namesi | Name:CRP1 Ordered Locus Names:YHR146W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001189, CRP1 |
VEuPathDBi | FungiDB:YHR146W |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- nucleotide-activated protein kinase complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202923 | 1 – 465 | Cruciform DNA-recognizing protein 1Add BLAST | 465 | |
ChainiPRO_0000409594 | 1 – 160 | CRP1 short N-terminal subpeptideAdd BLAST | 160 | |
ChainiPRO_0000409595 | 161 – 465 | CRP1 short C-terminal subpeptideAdd BLAST | 305 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 153 | PhosphoserineCombined sources | 1 | |
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Modified residuei | 182 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 343 | PhosphoserineCombined sources | 1 | |
Modified residuei | 366 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 394 | PhosphoserineCombined sources | 1 | |
Modified residuei | 440 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Cleaved in the vicinity of position 160 to give an X-DNA-binding N-terminal subpeptide and a non-DNA-binding C-terminal subpeptide.
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38845 |
PaxDbi | P38845 |
PRIDEi | P38845 |
PTM databases
iPTMneti | P38845 |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 36580, 140 interactors |
IntActi | P38845, 27 interactors |
MINTi | P38845 |
STRINGi | 4932.YHR146W |
Miscellaneous databases
RNActi | P38845, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 227 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 160 – 161 | X-DNA-binding | 2 | |
Regioni | 247 – 276 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 300 – 465 | DisorderedSequence analysisAdd BLAST | 166 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 129 – 148 | Basic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 169 – 185 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 334 – 367 | Basic and acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 388 – 432 | Basic and acidic residuesSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the CRP1/MDG1 family.Curated
Phylogenomic databases
eggNOGi | KOG1616, Eukaryota |
GeneTreei | ENSGT00940000176749 |
HOGENOMi | CLU_594765_0_0_1 |
InParanoidi | P38845 |
OMAi | TFSWPAG |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR032640, AMPK1_CBM IPR013783, Ig-like_fold IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF16561, AMPK1_CBM, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P38845-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSELMFNYT FSWPAGPKDV ILTGTFDDWR GTLPLVKTAK GNFEITMPVK
60 70 80 90 100
LANKDDTFQF KFIVDGVWCV SDSYKKEHVS EGIENNFLQI TDLVETQEVA
110 120 130 140 150
GASRIPEAGG LLCGKPPRSA GPPSTSNRKK NKRNNKKRRS KLKKKSTKNN
160 170 180 190 200
KKSNESLDDN EEEDGVTGTT TEDVTGTSRE ETPLAEPTNV SKEAPGNFHI
210 220 230 240 250
LPIDQSADTT QSNGIIGGPG PVLVPNPGEI KEFTEIRDVD ARELNERLNK
260 270 280 290 300
KEEVPEPVAG PIVESSVTEK SPALPQADDP IVETKEVAHN VQELTPQVEA
310 320 330 340 350
VTPLINEPEP LPTPEAQISI PESSKVEPVE GSLQSKLVEK RESTEGVLDG
360 370 380 390 400
SKKVENKAKK DEEVFTLDPI VNKAPKLPLT DEQTAEGRKS PAVSEEKEKK
410 420 430 440 450
KKQEKGSKEV KRSETSKEKK PSAKEVKKQT VKAPKKQTAS PLSSSTEEPK
460
KKKTGFFGKL KKLFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10397 Genomic DNA Translation: AAB68982.1 BK006934 Genomic DNA Translation: DAA06839.1 |
PIRi | S46759 |
RefSeqi | NP_012016.1, NM_001179277.1 |
Genome annotation databases
EnsemblFungii | YHR146W_mRNA; YHR146W; YHR146W |
GeneIDi | 856551 |
KEGGi | sce:YHR146W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10397 Genomic DNA Translation: AAB68982.1 BK006934 Genomic DNA Translation: DAA06839.1 |
PIRi | S46759 |
RefSeqi | NP_012016.1, NM_001179277.1 |
3D structure databases
SMRi | P38845 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36580, 140 interactors |
IntActi | P38845, 27 interactors |
MINTi | P38845 |
STRINGi | 4932.YHR146W |
PTM databases
iPTMneti | P38845 |
Proteomic databases
MaxQBi | P38845 |
PaxDbi | P38845 |
PRIDEi | P38845 |
Genome annotation databases
EnsemblFungii | YHR146W_mRNA; YHR146W; YHR146W |
GeneIDi | 856551 |
KEGGi | sce:YHR146W |
Organism-specific databases
SGDi | S000001189, CRP1 |
VEuPathDBi | FungiDB:YHR146W |
Phylogenomic databases
eggNOGi | KOG1616, Eukaryota |
GeneTreei | ENSGT00940000176749 |
HOGENOMi | CLU_594765_0_0_1 |
InParanoidi | P38845 |
OMAi | TFSWPAG |
Enzyme and pathway databases
Reactomei | R-SCE-1632852, Macroautophagy R-SCE-163680, AMPK inhibits chREBP transcriptional activation activity R-SCE-200425, Carnitine metabolism R-SCE-380972, Energy dependent regulation of mTOR by LKB1-AMPK |
Miscellaneous databases
PROi | PR:P38845 |
RNActi | P38845, protein |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR032640, AMPK1_CBM IPR013783, Ig-like_fold IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF16561, AMPK1_CBM, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CRP1_YEAST | |
Accessioni | P38845Primary (citable) accession number: P38845 Secondary accession number(s): D3DL95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families