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Entry version 141 (02 Jun 2021)
Sequence version 2 (27 Sep 2005)
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Protein

PH domain-containing protein YHR131C

Gene

YHR131C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH domain-containing protein YHR131C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YHR131C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000001173, YHR131C

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YHR131C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002029171 – 850PH domain-containing protein YHR131CAdd BLAST850

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38835

PRoteomics IDEntifications database

More...
PRIDEi
P38835

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38835

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
36563, 36 interactors

Protein interaction database and analysis system

More...
IntActi
P38835, 16 interactors

Molecular INTeraction database

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MINTi
P38835

STRING: functional protein association networks

More...
STRINGi
4932.YHR131C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38835, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini194 – 306PHAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni324 – 348DisorderedSequence analysisAdd BLAST25
Regioni406 – 428DisorderedSequence analysisAdd BLAST23
Regioni451 – 494DisorderedSequence analysisAdd BLAST44
Regioni583 – 659DisorderedSequence analysisAdd BLAST77
Regioni793 – 850DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi324 – 339Basic residuesSequence analysisAdd BLAST16
Compositional biasi472 – 486Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi588 – 621Polar residuesSequence analysisAdd BLAST34
Compositional biasi629 – 657Acidic residuesSequence analysisAdd BLAST29
Compositional biasi801 – 850Acidic residuesSequence analysisAdd BLAST50

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QUAB, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000176577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_012105_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38835

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSMYLSI

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPIEGKLS MANNRIERLK SPSSSSTCSM DEVLITSSNN SSSICLETMR
60 70 80 90 100
QLPREGVSGQ INIIKETAAS SSSHAALFIK QDLYEHIDPL PAYPPSYDLV
110 120 130 140 150
NPNKEVRFPI FGDTAPCPKS SLPPLYAPAV YELTLISLKL ERLSPYEISS
160 170 180 190 200
NRSWRNFIIE INSTQLNFYH IDESLTKHIR NYSSGETKSE KEDRIHSDLV
210 220 230 240 250
HRSDQSQHLH HRLFTLPTRS ASEFKKADQE RISYRVKRDR SRYLTDEALY
260 270 280 290 300
KSFTLQNARF GIPTDYTKKS FVLRMSCESE QFLLRFSHID DMIDWSMYLS
310 320 330 340 350
IGISVSLDLE VREYPDYRIV PRRRRRRRRR RRRRRHTHRS ESSMGSFSQR
360 370 380 390 400
FIRSNSRPDL IQRYSTGSST NNNTTIRERS NTFTAGLLDH YCTGLSKTPT
410 420 430 440 450
EALISSAASG ESSDNSTLGS TRSLSGCSAS RSIASRSLKF KIKNFFRPKN
460 470 480 490 500
SSRTEKLHRL RSNSSNLNSV IETEEDDEHH ESSGGDHPEP GVPVNTTIKV
510 520 530 540 550
ERPMHRNRAI SMPQRQSLRR AISEEVVPIK FPNSTVGESV HSPSPIEHLS
560 570 580 590 600
VDGCEIMLQS QNAVMKEELR SVASNLVANE RDEASIRPKP QSSSIYLSGL
610 620 630 640 650
APNGESATDL SQSSRSLCLT NRDAEINDDE SATETDEDEN DGETDEYAGD
660 670 680 690 700
DTNDDTDDSN IGYAYGSESD YSCLIEERIR NRRRASSTLS CFSNIPYGTD
710 720 730 740 750
DIKWKPAIKE ISRRRYLRDS LKCIKPFLDS NDCLGKVIYI PVSGPTFETS
760 770 780 790 800
NKIHFSNRQS LQKQKNHFLK GFIVGPTALI ELNCKNKNAI VGTTKDAEDH
810 820 830 840 850
GEDDGDGDDG EDDDDDDDDD DDDDDDEDDD DDDDDDDDDD DDDDDGQITA
Length:850
Mass (Da):96,099
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD63F340A8C736DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U10398 Genomic DNA Translation: AAB68414.2
BK006934 Genomic DNA Translation: DAA06823.1

Protein sequence database of the Protein Information Resource

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PIRi
S48975

NCBI Reference Sequences

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RefSeqi
NP_011999.2, NM_001179261.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHR131C_mRNA; YHR131C; YHR131C

Database of genes from NCBI RefSeq genomes

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GeneIDi
856532

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YHR131C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10398 Genomic DNA Translation: AAB68414.2
BK006934 Genomic DNA Translation: DAA06823.1
PIRiS48975
RefSeqiNP_011999.2, NM_001179261.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36563, 36 interactors
IntActiP38835, 16 interactors
MINTiP38835
STRINGi4932.YHR131C

PTM databases

iPTMnetiP38835

Proteomic databases

PaxDbiP38835
PRIDEiP38835

Genome annotation databases

EnsemblFungiiYHR131C_mRNA; YHR131C; YHR131C
GeneIDi856532
KEGGisce:YHR131C

Organism-specific databases

SGDiS000001173, YHR131C
VEuPathDBiFungiDB:YHR131C

Phylogenomic databases

eggNOGiENOG502QUAB, Eukaryota
GeneTreeiENSGT00940000176577
HOGENOMiCLU_012105_0_0_1
InParanoidiP38835
OMAiWSMYLSI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38835
RNActiP38835, protein

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38835
Secondary accession number(s): D3DL79
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 27, 2005
Last modified: June 2, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
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