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Protein

Origin recognition complex subunit 6

Gene

ORC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.2 Publications

Miscellaneous

Present with 2970 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

GO - Molecular functioni

  • DNA replication origin binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-31160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 6
Alternative name(s):
ACS-associated protein 1
Origin recognition complex 50 kDa subunit
Gene namesi
Name:ORC6
Synonyms:AAP1
Ordered Locus Names:YHR118C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR118C
SGDiS000001160 ORC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271021 – 435Origin recognition complex subunit 6Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38826
PaxDbiP38826
PRIDEiP38826

PTM databases

iPTMnetiP38826

Interactioni

Subunit structurei

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC3, ORC5 and TAH11.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi36551, 492 interactors
ComplexPortaliCPX-768 Nuclear origin recognition complex
DIPiDIP-2289N
ELMiP38826
IntActiP38826, 21 interactors
MINTiP38826
STRINGi4932.YHR118C

Structurei

3D structure databases

ProteinModelPortaliP38826
SMRiP38826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC6 family.Curated

Phylogenomic databases

HOGENOMiHOG000000884
InParanoidiP38826
KOiK02608
OMAiARCHICA
OrthoDBiEOG092C41WK

Family and domain databases

InterProiView protein in InterPro
IPR008721 ORC6
IPR016811 ORC6_fun
PfamiView protein in Pfam
PF05460 ORC6, 1 hit
PIRSFiPIRSF022941 ORC6_fun, 1 hit

Sequencei

Sequence statusi: Complete.

P38826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMQQVQHCV AEVLRLDPQE KPDWSSGYLK KLTNATSILY NTSLNKVMLK
60 70 80 90 100
QDEEVARCHI CAYIASQKMN EKHMPDLCYY IDSIPLEPKK AKHLMNLFRQ
110 120 130 140 150
SLSNSSPMKQ FAWTPSPKKN KRSPVKNGGR FTSSDPKELR NQLFGTPTKV
160 170 180 190 200
RKSQNNDSFV IPELPPMQTN ESPSITRRKL AFEEDEDEDE EEPGNDGLSL
210 220 230 240 250
KSHSNKSITG TRNVDSDEYE NHESDPTSEE EPLGVQESRS GRTKQNKAVG
260 270 280 290 300
KPQSELKTAK ALRKRGRIPN SLLVKKYCKM TTEEIIRLCN DFELPREVAY
310 320 330 340 350
KIVDEYNINA SRLVCPWQLV CGLVLNCTFI VFNERRRKDP RIDHFIVSKM
360 370 380 390 400
CSLMLTSKVD DVIECVKLVK ELIIGEKWFR DLQIRYDDFD GIRYDEIIFR
410 420 430
KLGSMLQTTN ILVTDDQYNI WKKRIEMDLA LTEPL
Length:435
Mass (Da):50,296
Last modified:November 1, 1995 - v2
Checksum:i22803C70378B7E85
GO

Sequence cautioni

The sequence AAB68869 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23323 Genomic DNA Translation: AAA21822.1
U00059 Genomic DNA Translation: AAB68869.1 Different initiation.
BK006934 Genomic DNA Translation: DAA06812.1
PIRiA49387
RefSeqiNP_011986.1, NM_001179248.1

Genome annotation databases

EnsemblFungiiYHR118C; YHR118C; YHR118C
GeneIDi856518
KEGGisce:YHR118C

Similar proteinsi

Entry informationi

Entry nameiORC6_YEAST
AccessioniPrimary (citable) accession number: P38826
Secondary accession number(s): D3DL68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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