UniProtKB - P38816 (TRXB2_YEAST)
Protein
Thioredoxin reductase 2, mitochondrial
Gene
TRR2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress.1 Publication
Miscellaneous
Present with 414 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.8.1.9
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 68 | FAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 77 | FADBy similarity | 1 | |
Binding sitei | 110 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 168 | FADBy similarity | 1 | |
Binding sitei | 311 | FADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 37 | FADBy similarity | 4 | |
Nucleotide bindingi | 56 – 68 | FADBy similarityAdd BLAST | 13 | |
Nucleotide bindingi | 63 – 64 | FADBy similarity | 2 | |
Nucleotide bindingi | 311 – 320 | FADBy similarity | 10 | |
Nucleotide bindingi | 318 – 320 | FADBy similarity | 3 |
GO - Molecular functioni
- thioredoxin-disulfide reductase activity Source: SGD
GO - Biological processi
- cell redox homeostasis Source: SGD
- cellular response to oxidative stress Source: SGD
- removal of superoxide radicals Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TRR2 Ordered Locus Names:YHR106W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001148, TRR2 |
VEuPathDBi | FungiDB:YHR106W |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Mitochondrion
- mitochondrion Source: SGD
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 23 | MitochondrionSequence analysisAdd BLAST | 23 | |
ChainiPRO_0000030303 | 24 – 342 | Thioredoxin reductase 2, mitochondrialAdd BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 165 ↔ 168 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | P38816 |
PaxDbi | P38816 |
PRIDEi | P38816 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
P38816
With | #Exp. | IntAct |
---|---|---|
TRR1 [P29509] | 4 | EBI-19502,EBI-19497 |
Protein-protein interaction databases
BioGRIDi | 36539, 49 interactors |
DIPi | DIP-1942N |
IntActi | P38816, 2 interactors |
MINTi | P38816 |
STRINGi | 4932.YHR106W |
Miscellaneous databases
RNActi | P38816, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active center, Transit peptidePhylogenomic databases
eggNOGi | KOG0404, Eukaryota |
GeneTreei | ENSGT00940000176591 |
HOGENOMi | CLU_031864_5_1_1 |
InParanoidi | P38816 |
OMAi | FRAEDYW |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR008255, Pyr_nucl-diS_OxRdtase_2_AS IPR005982, Thioredox_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR01292, TRX_reduct, 1 hit |
PROSITEi | View protein in PROSITE PS00573, PYRIDINE_REDOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P38816-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKHIVSPFR TNFVGISKSV LSRMIHHKVT IIGSGPAAHT AAIYLARAEM
60 70 80 90 100
KPTLYEGMMA NGIAAGGQLT TTTDIENFPG FPESLSGSEL MERMRKQSAK
110 120 130 140 150
FGTNIITETV SKVDLSSKPF RLWTEFNEDA EPVTTDAIIL ATGASAKRMH
160 170 180 190 200
LPGEETYWQQ GISACAVCDG AVPIFRNKPL AVIGGGDSAC EEAEFLTKYA
210 220 230 240 250
SKVYILVRKD HFRASVIMQR RIEKNPNIIV LFNTVALEAK GDGKLLNMLR
260 270 280 290 300
IKNTKSNVEN DLEVNGLFYA IGHSPATDIV KGQVDEEETG YIKTVPGSSL
310 320 330 340
TSVPGFFAAG DVQDSRYRQA VTSAGSGCIA ALDAERYLSA QE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00059 Genomic DNA Translation: AAB68856.1 AY557882 Genomic DNA Translation: AAS56208.1 BK006934 Genomic DNA Translation: DAA06800.1 |
PIRi | S48948 |
RefSeqi | NP_011974.1, NM_001179236.1 |
Genome annotation databases
EnsemblFungii | YHR106W_mRNA; YHR106W; YHR106W |
GeneIDi | 856506 |
KEGGi | sce:YHR106W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00059 Genomic DNA Translation: AAB68856.1 AY557882 Genomic DNA Translation: AAS56208.1 BK006934 Genomic DNA Translation: DAA06800.1 |
PIRi | S48948 |
RefSeqi | NP_011974.1, NM_001179236.1 |
3D structure databases
SMRi | P38816 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36539, 49 interactors |
DIPi | DIP-1942N |
IntActi | P38816, 2 interactors |
MINTi | P38816 |
STRINGi | 4932.YHR106W |
Proteomic databases
MaxQBi | P38816 |
PaxDbi | P38816 |
PRIDEi | P38816 |
Genome annotation databases
EnsemblFungii | YHR106W_mRNA; YHR106W; YHR106W |
GeneIDi | 856506 |
KEGGi | sce:YHR106W |
Organism-specific databases
SGDi | S000001148, TRR2 |
VEuPathDBi | FungiDB:YHR106W |
Phylogenomic databases
eggNOGi | KOG0404, Eukaryota |
GeneTreei | ENSGT00940000176591 |
HOGENOMi | CLU_031864_5_1_1 |
InParanoidi | P38816 |
OMAi | FRAEDYW |
Miscellaneous databases
PROi | PR:P38816 |
RNActi | P38816, protein |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR008255, Pyr_nucl-diS_OxRdtase_2_AS IPR005982, Thioredox_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR01292, TRX_reduct, 1 hit |
PROSITEi | View protein in PROSITE PS00573, PYRIDINE_REDOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRXB2_YEAST | |
Accessioni | P38816Primary (citable) accession number: P38816 Secondary accession number(s): D3DL56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families