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Entry version 185 (07 Oct 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Transcription-associated protein 1

Gene

TRA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of histone acetyltransferase (HAT) complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.2 Publications

Miscellaneous

Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it may lack such activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription-associated protein 1
Alternative name(s):
p400 kDa component of SAGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRA1
Ordered Locus Names:YHR099W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YHR099W

Saccharomyces Genome Database

More...
SGDi
S000001141, TRA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi241L → S in TRA1-2; when associated with L-604; R-2733; P-3145; S-3222 and G-3302. Defects in its ability to interact with acidic activators. 1
Mutagenesisi604F → L in TRA1-2; when associated with S-241; R-2733; P-3145; S-3222 and G-3302. Defects in its ability to interact with acidic activators. 1
Mutagenesisi2733W → R in TRA1-2; when associated with S-241; L-604; P-3145; S-3222 and G-3302. Defects in its ability to interact with acidic activators. 1
Mutagenesisi3145S → P in TRA1-2; when associated with S-241; L-604; R-2733; S-3222 and G-3302. Defects in its ability to interact with acidic activators. 1
Mutagenesisi3222L → S in TRA1-2; when associated with S-241; L-604; R-2733; P-3145 and G-3302. Defects in its ability to interact with acidic activators. 1
Mutagenesisi3302D → G in TRA1-2; when associated with S-241; L-604; R-2733; P-3145 and S-3222. Defects in its ability to interact with acidic activators. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888542 – 3744Transcription-associated protein 1Add BLAST3743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38811

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38811

PRoteomics IDEntifications database

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PRIDEi
P38811

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38811

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA.

Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3.

Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7,TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Also identified in the NuA4 complex with ESA1. Identified in the Ada.spt complex with ADA3 and SPT7.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
36532, 265 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3155, NuA4 histone acetyltransferase complex
CPX-656, SAGA complex
CPX-675, SLIK (SAGA-like) complex

Database of interacting proteins

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DIPi
DIP-805N

Protein interaction database and analysis system

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IntActi
P38811, 73 interactors

Molecular INTeraction database

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MINTi
P38811

STRING: functional protein association networks

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STRINGi
4932.YHR099W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P38811, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13744
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38811

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2622 – 3177FATPROSITE-ProRule annotationAdd BLAST556
Domaini3414 – 3711PI3K/PI4KAdd BLAST298
Domaini3712 – 3744FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain (2233-2836) is essential for its ability to interact with activators.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0889, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000017961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000129_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38811

KEGG Orthology (KO)

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KOi
K08874

Identification of Orthologs from Complete Genome Data

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OMAi
HLSYLMR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR033317, TRA1/TRRAP

The PANTHER Classification System

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PANTHERi
PTHR11139:SF1, PTHR11139:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371, SSF48371, 3 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P38811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTEQIEQF ASRFRDDDAT LQSRYSTLSE LYDIMELLNS PEDYHFFLQA
60 70 80 90 100
VIPLLLNQLK EVPISYDAHS PEQKLRNSML DIFNRCLMNQ TFQPYAMEVL
110 120 130 140 150
EFLLSVLPKE NEENGILCMK VLTTLFKSFK SILQDKLDSF IRIIIQIYKN
160 170 180 190 200
TPNLINQTFY EAGKAEQGDL DSPKEPQADE LLDEFSKNDE EKDFPSKQSS
210 220 230 240 250
TEPRFENSTS SNGLRSSMFS FKILSECPIT MVTLYSSYKQ LTSTSLPEFT
260 270 280 290 300
PLIMNLLNIQ IKQQQEAREQ AESRGEHFTS ISTEIINRPA YCDFILAQIK
310 320 330 340 350
ATSFLAYVFI RGYAPEFLQD YVNFVPDLII RLLQDCPSEL SSARKELLHA
360 370 380 390 400
TRHILSTNYK KLFLPKLDYL FDERILIGNG FTMHETLRPL AYSTVADFIH
410 420 430 440 450
NIRSELQLSE IEKTIKIYTG YLLDESLALT VQIMSAKLLL NLVERILKLG
460 470 480 490 500
KENPQEAPRA KKLLMIIIDS YMNRFKTLNR QYDTIMKYYG RYETHKKEKA
510 520 530 540 550
EKLKNSIQDN DKESEEFMRK VLEPSDDDHL MPQPKKEDIN DSPDVEMTES
560 570 580 590 600
DKVVKNDVEM FDIKNYAPIL LLPTPTNDPI KDAFYLYRTL MSFLKTIIHD
610 620 630 640 650
LKVFNPPPNE YTVANPKLWA SVSRVFSYEE VIVFKDLFHE CIIGLKFFKD
660 670 680 690 700
HNEKLSPETT KKHFDISMPS LPVSATKDAR ELMDYLAFMF MQMDNATFNE
710 720 730 740 750
IIEQELPFVY ERMLEDSGLL HVAQSFLTSE ITSPNFAGIL LRFLKGKLKD
760 770 780 790 800
LGNVDFNTSN VLIRLFKLSF MSVNLFPNIN EVVLLPHLND LILNSLKYST
810 820 830 840 850
TAEEPLVYFY LIRTLFRSIG GGRFENLYRS IKPILQVLLQ SLNQMILTAR
860 870 880 890 900
LPHERELYVE LCITVPVRLS VLAPYLPFLM KPLVFALQQY PDLVSQGLRT
910 920 930 940 950
LELCIDNLTA EYFDPIIEPV IDDVSKALFN LLQPQPFNHA ISHNVVRILG
960 970 980 990 1000
KLGGRNRQFL KPPTDLTEKT ELDIDAIADF KINGMPEDVP LSVTPGIQSA
1010 1020 1030 1040 1050
LNILQSYKSD IHYRKSAYKY LTCVLLLMTK SSAEFPTNYT ELLKTAVNSI
1060 1070 1080 1090 1100
KLERIGIEKN FDLEPTVNKR DYSNQENLFL RLLESVFYAT SIKELKDDAM
1110 1120 1130 1140 1150
DLLNNLLDHF CLLQVNTTLL NKRNYNGTFN IDLKNPNFML DSSLILDAIP
1160 1170 1180 1190 1200
FALSYYIPEV REVGVLAYKR IYEKSCLIYG EELALSHSFI PELAKQFIHL
1210 1220 1230 1240 1250
CYDETYYNKR GGVLGIKVLI DNVKSSSVFL KKYQYNLANG LLFVLKDTQS
1260 1270 1280 1290 1300
EAPSAITDSA EKLLIDLLSI TFADVKEEDL GNKVLENTLT DIVCELSNAN
1310 1320 1330 1340 1350
PKVRNACQKS LHTISNLTGI PIVKLMDHSK QFLLSPIFAK PLRALPFTMQ
1360 1370 1380 1390 1400
IGNVDAITFC LSLPNTFLTF NEELFRLLQE SIVLADAEDE SLSTNIQKTT
1410 1420 1430 1440 1450
EYSTSEQLVQ LRIACIKLLA IALKNEEFAT AQQGNIRIRI LAVFFKTMLK
1460 1470 1480 1490 1500
TSPEIINTTY EALKGSLAEN SKLPKELLQN GLKPLLMNLS DHQKLTVPGL
1510 1520 1530 1540 1550
DALSKLLELL IAYFKVEIGR KLLDHLTAWC RVEVLDTLFG QDLAEQMPTK
1560 1570 1580 1590 1600
IIVSIINIFH LLPPQADMFL NDLLLKVMLL ERKLRLQLDS PFRTPLARYL
1610 1620 1630 1640 1650
NRFHNPVTEY FKKNMTLRQL VLFMCNIVQR PEAKELAEDF EKELDNFYDF
1660 1670 1680 1690 1700
YISNIPKNQV RVVSFFTNMV DLFNTMVITN GDEWLKKKGN MILKLKDMLN
1710 1720 1730 1740 1750
LTLKTIKENS FYIDHLQLNQ SIAKFQALYL RFTELSERDQ NPLLLDFIDF
1760 1770 1780 1790 1800
SFSNGIKASY SLKKFIFHNI IASSNKEKQN NFINDATLFV LSDKCLDARI
1810 1820 1830 1840 1850
FVLKNVINST LIYEVATSGS LKSYLVEDKK PKWLELLHNK IWKNSNAILA
1860 1870 1880 1890 1900
YDVLDHHDLF RFELLQLSAI FIKADPEIIA EIKKDIIKFC WNFIKLEDTL
1910 1920 1930 1940 1950
IKQSAYLVTS YFISKFDFPI KVVTQVFVAL LRSSHVEARY LVKQSLDVLT
1960 1970 1980 1990 2000
PVLHERMNAA GTPDTWINWV KRVMVENSSS QNNILYQFLI SHPDLFFNSR
2010 2020 2030 2040 2050
DLFISNIIHH MNKITFMSNS NSDSHTLAID LASLILYWEN KTLEITNVNN
2060 2070 2080 2090 2100
TKTDSDGDVV MSDSKSDINP VEADTTAIIV DANNNSPISL HLREACTAFL
2110 2120 2130 2140 2150
IRYVCASNHR AIETELGLRA INILSELISD KHWTNVNVKL VYFEKFLIFQ
2160 2170 2180 2190 2200
DLDSENILYY CMNALDVLYV FFKNKTKEWI MENLPTIQNL LEKCIKSDHH
2210 2220 2230 2240 2250
DVQEALQKVL QVIMKAIKAQ GVSVIIEEES PGKTFIQMLT SVITQDLQET
2260 2270 2280 2290 2300
SSVTAGVTLA WVLFMNFPDN IVPLLTPLMK TFSKLCKDHL SISQPKDAMA
2310 2320 2330 2340 2350
LEEARITTKL LEKVLYILSL KVSLLGDSRR PFLSTVALLI DHSMDQNFLR
2360 2370 2380 2390 2400
KIVNMSRSWI FNTEIFPTVK EKAAILTKML AFEIRGEPSL SKLFYEIVLK
2410 2420 2430 2440 2450
LFDQEHFNNT EITVRMEQPF LVGTRVEDIG IRKRFMTILD NSLERDIKER
2460 2470 2480 2490 2500
LYYVIRDQNW EFIADYPWLN QALQLLYGSF NREKELSLKN IYCLSPPSIL
2510 2520 2530 2540 2550
QEYLPENAEM VTEVNDLELS NFVKGHIASM QGLCRIISSD FIDSLIEIFY
2560 2570 2580 2590 2600
QDPKAIHRAW VTLFPQVYKS IPKNEKYGFV RSIITLLSKP YHTRQISSRT
2610 2620 2630 2640 2650
NVINMLLDSI SKIESLELPP HLVKYLAISY NAWYQSINIL ESIQSNTSID
2660 2670 2680 2690 2700
NTKIIEANED ALLELYVNLQ EEDMFYGLWR RRAKYTETNI GLSYEQIGLW
2710 2720 2730 2740 2750
DKAQQLYEVA QVKARSGALP YSQSEYALWE DNWIQCAEKL QHWDVLTELA
2760 2770 2780 2790 2800
KHEGFTDLLL ECGWRVADWN SDRDALEQSV KSVMDVPTPR RQMFKTFLAL
2810 2820 2830 2840 2850
QNFAESRKGD QEVRKLCDEG IQLSLIKWVS LPIRYTPAHK WLLHGFQQYM
2860 2870 2880 2890 2900
EFLEATQIYA NLHTTTVQNL DSKAQEIKRI LQAWRDRLPN TWDDVNMWND
2910 2920 2930 2940 2950
LVTWRQHAFQ VINNAYLPLI PALQQSNSNS NINTHAYRGY HEIAWVINRF
2960 2970 2980 2990 3000
AHVARKHNMP DVCISQLARI YTLPNIEIQE AFLKLREQAK CHYQNMNELT
3010 3020 3030 3040 3050
TGLDVISNTN LVYFGTVQKA EFFTLKGMFL SKLRAYEEAN QAFATAVQID
3060 3070 3080 3090 3100
LNLAKAWAQW GFFNDRRLSE EPNNISFASN AISCYLQAAG LYKNSKIREL
3110 3120 3130 3140 3150
LCRILWLISI DDASGMLTNA FDSFRGEIPV WYWITFIPQL LTSLSHKEAN
3160 3170 3180 3190 3200
MVRHILIRIA KSYPQALHFQ LRTTKEDFAV IQRQTMAVMG DKPDTNDRNG
3210 3220 3230 3240 3250
RRQPWEYLQE LNNILKTAYP LLALSLESLV AQINDRFKST TDEDLFRLIN
3260 3270 3280 3290 3300
VLLIDGTLNY NRLPFPRKNP KLPENTEKNL VKFSTTLLAP YIRPKFNADF
3310 3320 3330 3340 3350
IDNKPDYETY IKRLRYWRRR LENKLDRASK KENLEVLCPH LSNFHHQKFE
3360 3370 3380 3390 3400
DIEIPGQYLL NKDNNVHFIK IARFLPTVDF VRGTHSSYRR LMIRGHDGSV
3410 3420 3430 3440 3450
HSFAVQYPAV RHSRREERMF QLYRLFNKSL SKNVETRRRS IQFNLPIAIP
3460 3470 3480 3490 3500
LSPQVRIMND SVSFTTLHEI HNEFCKKKGF DPDDIQDFMA DKLNAAHDDA
3510 3520 3530 3540 3550
LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED FWLFRKQFAS
3560 3570 3580 3590 3600
QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL
3610 3620 3630 3640 3650
KNHDLSLPPD SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR
3660 3670 3680 3690 3700
ALIEPDNELN TYLALFIRDE IISWFSNLHR PIIENPQLRE MVQTNVDLII
3710 3720 3730 3740
RKVAQLGHLN STPTVTTQFI LDCIGSAVSP RNLARTDVNF MPWF
Length:3,744
Mass (Da):433,180
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE3588676F5D5777
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68923.1
BK006934 Genomic DNA Translation: DAA06793.1

Protein sequence database of the Protein Information Resource

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PIRi
S46715

NCBI Reference Sequences

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RefSeqi
NP_011967.1, NM_001179229.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YHR099W_mRNA; YHR099W; YHR099W

Database of genes from NCBI RefSeq genomes

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GeneIDi
856499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHR099W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68923.1
BK006934 Genomic DNA Translation: DAA06793.1
PIRiS46715
RefSeqiNP_011967.1, NM_001179229.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OJSelectron microscopy3.70T1-3744[»]
6IG9electron microscopy4.60T1-3744[»]
6T9Ielectron microscopy3.90T1-3744[»]
6T9Jelectron microscopy3.40T1-3744[»]
SMRiP38811
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36532, 265 interactors
ComplexPortaliCPX-3155, NuA4 histone acetyltransferase complex
CPX-656, SAGA complex
CPX-675, SLIK (SAGA-like) complex
DIPiDIP-805N
IntActiP38811, 73 interactors
MINTiP38811
STRINGi4932.YHR099W

PTM databases

iPTMnetiP38811

Proteomic databases

MaxQBiP38811
PaxDbiP38811
PRIDEiP38811

Genome annotation databases

EnsemblFungiiYHR099W_mRNA; YHR099W; YHR099W
GeneIDi856499
KEGGisce:YHR099W

Organism-specific databases

EuPathDBiFungiDB:YHR099W
SGDiS000001141, TRA1

Phylogenomic databases

eggNOGiKOG0889, Eukaryota
GeneTreeiENSGT00390000017961
HOGENOMiCLU_000129_1_0_1
InParanoidiP38811
KOiK08874
OMAiHLSYLMR

Miscellaneous databases

Protein Ontology

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PROi
PR:P38811
RNActiP38811, protein

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR033317, TRA1/TRRAP
PANTHERiPTHR11139:SF1, PTHR11139:SF1, 1 hit
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRA1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38811
Secondary accession number(s): D3DL49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 7, 2020
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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