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UniProtKB - P38810 (SFB3_YEAST)

Entry version 180 (25 May 2022)
Sequence version 1 (01 Feb 1995)
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Protein

SED5-binding protein 3

Gene

SFB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Miscellaneous

Present with 12200 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-204005, COPII-mediated vesicle transport
R-SCE-5694530, Cargo concentration in the ER
R-SCE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SED5-binding protein 3
Alternative name(s):
Lethal with SEC13 protein 1
SEC24-related protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFB3
Synonyms:LST1
Ordered Locus Names:YHR098C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000001140, SFB3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YHR098C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051521 – 929SED5-binding protein 3Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei72PhosphothreonineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P38810

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P38810

PRoteomics IDEntifications database

More...PRIDEi		P38810

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P38810

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Binds to SED5.

Interacts with GHR1.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		36531, 393 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1341, SEC23-LST1 COPII cargo recruitment complex

Database of interacting proteins

More...DIPi		DIP-2949N

Protein interaction database and analysis system

More...IntActi		P38810, 12 interactors

Molecular INTeraction database

More...MINTi		P38810

STRING: functional protein association networks

More...STRINGi		4932.YHR098C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P38810, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P38810

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P38810

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 52DisorderedSequence analysisAdd BLAST35
Regioni220 – 244Zinc finger-likeAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1984, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004589_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P38810

Identification of Orthologs from Complete Genome Data

More...OMAi		DRRVHDM

Family and domain databases

Conserved Domains Database

More...CDDi		cd01479, Sec24-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQNILAAS VSALSLDEST VHTGGASSKK SRRPHRAYHN FSSGTVPTLG 
        60         70         80         90        100
NSPYTTPQLN QQDGFQQPQA FTPKQFGGFN NGSGSVMSTP VMVSQERFGA 
       110        120        130        140        150
SEASSPYGQS MLDMTAPQPT SHIVPTQRFE DQAQYLQRSF ETCRDSVPPL 
       160        170        180        190        200
PTTQFYCVDQ GSCDPHLMSL SMYNIPESEH LRAATKLPLG LTIQPFSTLT 
       210        220        230        240        250
PNDAEVPTIP LPMDGTPLRC RRCRAYANPK FQFTYDSSVI CNICRVKMQV 
       260        270        280        290        300
PGEHFAPMGP NGQRSDLNEK SELLHGTVDF LVPSIYNAIQ EKELLPLHYV 
       310        320        330        340        350
FLIDVSLLAN ENGSSLAMVE GVRSCIEYIS DFQPNCEVAI IVYDNKLRFF 
       360        370        380        390        400
NLRPDLDNAQ EYIVSELDDV FLPFYNGLFV KPGNSMKIIN DTLIKISGYI 
       410        420        430        440        450
STDKYSHVPQ VCYGSALQAA KLALDTVTGG QGGKIICSLN SLPTIGNGNL 
       460        470        480        490        500
SLKRDNAHIA HVKCDNGFYK KLASDFLKSY ISLDLYVTNA GFIDMATVGH 
       510        520        530        540        550
PVEMTSGILK YYPHFQQETD AFTLVNDMVT NVSNIVGYQA LLKVRCSTGL 
       560        570        580        590        600
SVEQYYCDSS DNTDHDPIIP VLTRDTTLDV LLKYDSKIKT GTDVHFQTAL 
       610        620        630        640        650
LYTDIDGVRK VRSINTSGAV SNNIREIFKF INQNPVMRIM IKDVIKTLGD 
       660        670        680        690        700
CDFVKIRRLI DDKMVEILTQ YRGLVSSNSS TQLILPDSIK TLPAYMLAFE 
       710        720        730        740        750
KSELMKPNAQ STRGNERIYD LLKYDSLNSA QLCYKLYPQI VPFHVLLEET 
       760        770        780        790        800
DLTFYDANDK LLQINSSSIN NLSVRASHSN FINGGCYLIF QGDTIYLWFN 
       810        820        830        840        850
ENTNRMLLQD LLSVDESLPV SQISLFSGTL PETGTSINQK ASNVIKNWQQ 
       860        870        880        890        900
VVNKSSLPLV LLRPNVDQYY SNVMSQLLCE DKTVNRIESY DNYLVIMHKK 
       910        920 
IQEKLQKDDF IKVSTAATHE NIHQKFVQF
Length:929
Mass (Da):103,950
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A028AD6B1A2E031
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68936.1
AJ009784 Genomic DNA Translation: CAA08831.1
BK006934 Genomic DNA Translation: DAA06792.1

Protein sequence database of the Protein Information Resource

More...PIRi		S46728

NCBI Reference Sequences

More...RefSeqi		NP_011966.1, NM_001179228.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YHR098C_mRNA; YHR098C; YHR098C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		856498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YHR098C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68936.1
AJ009784 Genomic DNA Translation: CAA08831.1
BK006934 Genomic DNA Translation: DAA06792.1
PIRiS46728
RefSeqiNP_011966.1, NM_001179228.1

3D structure databases

AlphaFoldDBiP38810
SMRiP38810
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36531, 393 interactors
ComplexPortaliCPX-1341, SEC23-LST1 COPII cargo recruitment complex
DIPiDIP-2949N
IntActiP38810, 12 interactors
MINTiP38810
STRINGi4932.YHR098C

PTM databases

iPTMnetiP38810

Proteomic databases

MaxQBiP38810
PaxDbiP38810
PRIDEiP38810

Genome annotation databases

EnsemblFungiiYHR098C_mRNA; YHR098C; YHR098C
GeneIDi856498
KEGGisce:YHR098C

Organism-specific databases

SGDiS000001140, SFB3
VEuPathDBiFungiDB:YHR098C

Phylogenomic databases

eggNOGiKOG1984, Eukaryota
GeneTreeiENSGT00950000182924
HOGENOMiCLU_004589_1_0_1
InParanoidiP38810
OMAiDRRVHDM

Enzyme and pathway databases

ReactomeiR-SCE-204005, COPII-mediated vesicle transport
R-SCE-5694530, Cargo concentration in the ER
R-SCE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

Protein Ontology

More...PROi		PR:P38810
RNActiP38810, protein

Family and domain databases

CDDicd01479, Sec24-like, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFB3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38810
Secondary accession number(s): D3DL48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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