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Protein

SED5-binding protein 3

Gene

SFB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Miscellaneous

Present with 12200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • signal sequence binding Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31143-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
SED5-binding protein 3
Alternative name(s):
Lethal with SEC13 protein 1
SEC24-related protein 3
Gene namesi
Name:SFB3
Synonyms:LST1
Ordered Locus Names:YHR098C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR098C
SGDiS000001140 SFB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051521 – 929SED5-binding protein 3Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei72PhosphothreonineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38810
PaxDbiP38810
PRIDEiP38810

PTM databases

iPTMnetiP38810

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Binds to SED5. Interacts with GHR1.1 Publication

Protein-protein interaction databases

BioGridi36531, 383 interactors
ComplexPortaliCPX-1341 SEC23-LST1 COPII cargo recruitment complex
DIPiDIP-2949N
IntActiP38810, 11 interactors
MINTiP38810
STRINGi4932.YHR098C

Structurei

3D structure databases

ProteinModelPortaliP38810
SMRiP38810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 244Zinc finger-likeAdd BLAST25

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000141722
InParanoidiP38810
KOiK14007
OMAiKDRHAYH
OrthoDBiEOG092C0DKG

Family and domain databases

Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequencei

Sequence statusi: Complete.

P38810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQNILAAS VSALSLDEST VHTGGASSKK SRRPHRAYHN FSSGTVPTLG
60 70 80 90 100
NSPYTTPQLN QQDGFQQPQA FTPKQFGGFN NGSGSVMSTP VMVSQERFGA
110 120 130 140 150
SEASSPYGQS MLDMTAPQPT SHIVPTQRFE DQAQYLQRSF ETCRDSVPPL
160 170 180 190 200
PTTQFYCVDQ GSCDPHLMSL SMYNIPESEH LRAATKLPLG LTIQPFSTLT
210 220 230 240 250
PNDAEVPTIP LPMDGTPLRC RRCRAYANPK FQFTYDSSVI CNICRVKMQV
260 270 280 290 300
PGEHFAPMGP NGQRSDLNEK SELLHGTVDF LVPSIYNAIQ EKELLPLHYV
310 320 330 340 350
FLIDVSLLAN ENGSSLAMVE GVRSCIEYIS DFQPNCEVAI IVYDNKLRFF
360 370 380 390 400
NLRPDLDNAQ EYIVSELDDV FLPFYNGLFV KPGNSMKIIN DTLIKISGYI
410 420 430 440 450
STDKYSHVPQ VCYGSALQAA KLALDTVTGG QGGKIICSLN SLPTIGNGNL
460 470 480 490 500
SLKRDNAHIA HVKCDNGFYK KLASDFLKSY ISLDLYVTNA GFIDMATVGH
510 520 530 540 550
PVEMTSGILK YYPHFQQETD AFTLVNDMVT NVSNIVGYQA LLKVRCSTGL
560 570 580 590 600
SVEQYYCDSS DNTDHDPIIP VLTRDTTLDV LLKYDSKIKT GTDVHFQTAL
610 620 630 640 650
LYTDIDGVRK VRSINTSGAV SNNIREIFKF INQNPVMRIM IKDVIKTLGD
660 670 680 690 700
CDFVKIRRLI DDKMVEILTQ YRGLVSSNSS TQLILPDSIK TLPAYMLAFE
710 720 730 740 750
KSELMKPNAQ STRGNERIYD LLKYDSLNSA QLCYKLYPQI VPFHVLLEET
760 770 780 790 800
DLTFYDANDK LLQINSSSIN NLSVRASHSN FINGGCYLIF QGDTIYLWFN
810 820 830 840 850
ENTNRMLLQD LLSVDESLPV SQISLFSGTL PETGTSINQK ASNVIKNWQQ
860 870 880 890 900
VVNKSSLPLV LLRPNVDQYY SNVMSQLLCE DKTVNRIESY DNYLVIMHKK
910 920
IQEKLQKDDF IKVSTAATHE NIHQKFVQF
Length:929
Mass (Da):103,950
Last modified:February 1, 1995 - v1
Checksum:i6A028AD6B1A2E031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68936.1
AJ009784 Genomic DNA Translation: CAA08831.1
BK006934 Genomic DNA Translation: DAA06792.1
PIRiS46728
RefSeqiNP_011966.1, NM_001179228.1

Genome annotation databases

EnsemblFungiiYHR098C; YHR098C; YHR098C
GeneIDi856498
KEGGisce:YHR098C

Similar proteinsi

Entry informationi

Entry nameiSFB3_YEAST
AccessioniPrimary (citable) accession number: P38810
Secondary accession number(s): D3DL48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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