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UniProtKB - P38810 (SFB3_YEAST)
Protein
SED5-binding protein 3
Gene
SFB3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
Miscellaneous
Present with 12200 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- signal sequence binding Source: SGD
- SNARE binding Source: GO_Central
- zinc ion binding Source: GO_Central
GO - Biological processi
- COPII-coated vesicle cargo loading Source: SGD
- intracellular protein transport Source: ComplexPortal
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-204005, COPII-mediated vesicle transport R-SCE-5694530, Cargo concentration in the ER R-SCE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Recommended name: SED5-binding protein 3Alternative name(s): Lethal with SEC13 protein 1 SEC24-related protein 3 |
Gene namesi | Name:SFB3 Synonyms:LST1 Ordered Locus Names:YHR098C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001140, SFB3 |
VEuPathDBi | FungiDB:YHR098C |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum exit site Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- cell periphery Source: SGD
- COPII vesicle coat Source: SGD
- mating projection tip Source: SGD
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205152 | 1 – 929 | SED5-binding protein 3Add BLAST | 929 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 72 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Modified residuei | 94 | PhosphoserineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 216 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38810 |
PaxDbi | P38810 |
PRIDEi | P38810 |
PTM databases
iPTMneti | P38810 |
Interactioni
Subunit structurei
COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Binds to SED5.
Interacts with GHR1.
1 PublicationGO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 36531, 393 interactors |
ComplexPortali | CPX-1341, SEC23-LST1 COPII cargo recruitment complex |
DIPi | DIP-2949N |
IntActi | P38810, 12 interactors |
MINTi | P38810 |
STRINGi | 4932.YHR098C |
Miscellaneous databases
RNActi | P38810, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 52 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 220 – 244 | Zinc finger-likeAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1984, Eukaryota |
GeneTreei | ENSGT00950000182924 |
HOGENOMi | CLU_004589_1_0_1 |
InParanoidi | P38810 |
OMAi | DRRVHDM |
Family and domain databases
CDDi | cd01479, Sec24-like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR006900, Sec23/24_helical_dom IPR036175, Sec23/24_helical_dom_sf IPR006896, Sec23/24_trunk_dom IPR012990, Sec23_24_beta_S IPR041742, Sec24-like_trunk_dom IPR036465, vWFA_dom_sf IPR006895, Znf_Sec23_Sec24 IPR036174, Znf_Sec23_Sec24_sf |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit PF08033, Sec23_BS, 1 hit PF04815, Sec23_helical, 1 hit PF04811, Sec23_trunk, 1 hit PF04810, zf-Sec23_Sec24, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF81811, SSF81811, 1 hit SSF82754, SSF82754, 1 hit SSF82919, SSF82919, 1 hit |
i Sequence
Sequence statusi: Complete.
P38810-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQQNILAAS VSALSLDEST VHTGGASSKK SRRPHRAYHN FSSGTVPTLG
60 70 80 90 100
NSPYTTPQLN QQDGFQQPQA FTPKQFGGFN NGSGSVMSTP VMVSQERFGA
110 120 130 140 150
SEASSPYGQS MLDMTAPQPT SHIVPTQRFE DQAQYLQRSF ETCRDSVPPL
160 170 180 190 200
PTTQFYCVDQ GSCDPHLMSL SMYNIPESEH LRAATKLPLG LTIQPFSTLT
210 220 230 240 250
PNDAEVPTIP LPMDGTPLRC RRCRAYANPK FQFTYDSSVI CNICRVKMQV
260 270 280 290 300
PGEHFAPMGP NGQRSDLNEK SELLHGTVDF LVPSIYNAIQ EKELLPLHYV
310 320 330 340 350
FLIDVSLLAN ENGSSLAMVE GVRSCIEYIS DFQPNCEVAI IVYDNKLRFF
360 370 380 390 400
NLRPDLDNAQ EYIVSELDDV FLPFYNGLFV KPGNSMKIIN DTLIKISGYI
410 420 430 440 450
STDKYSHVPQ VCYGSALQAA KLALDTVTGG QGGKIICSLN SLPTIGNGNL
460 470 480 490 500
SLKRDNAHIA HVKCDNGFYK KLASDFLKSY ISLDLYVTNA GFIDMATVGH
510 520 530 540 550
PVEMTSGILK YYPHFQQETD AFTLVNDMVT NVSNIVGYQA LLKVRCSTGL
560 570 580 590 600
SVEQYYCDSS DNTDHDPIIP VLTRDTTLDV LLKYDSKIKT GTDVHFQTAL
610 620 630 640 650
LYTDIDGVRK VRSINTSGAV SNNIREIFKF INQNPVMRIM IKDVIKTLGD
660 670 680 690 700
CDFVKIRRLI DDKMVEILTQ YRGLVSSNSS TQLILPDSIK TLPAYMLAFE
710 720 730 740 750
KSELMKPNAQ STRGNERIYD LLKYDSLNSA QLCYKLYPQI VPFHVLLEET
760 770 780 790 800
DLTFYDANDK LLQINSSSIN NLSVRASHSN FINGGCYLIF QGDTIYLWFN
810 820 830 840 850
ENTNRMLLQD LLSVDESLPV SQISLFSGTL PETGTSINQK ASNVIKNWQQ
860 870 880 890 900
VVNKSSLPLV LLRPNVDQYY SNVMSQLLCE DKTVNRIESY DNYLVIMHKK
910 920
IQEKLQKDDF IKVSTAATHE NIHQKFVQF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00060 Genomic DNA Translation: AAB68936.1 AJ009784 Genomic DNA Translation: CAA08831.1 BK006934 Genomic DNA Translation: DAA06792.1 |
PIRi | S46728 |
RefSeqi | NP_011966.1, NM_001179228.1 |
Genome annotation databases
EnsemblFungii | YHR098C_mRNA; YHR098C; YHR098C |
GeneIDi | 856498 |
KEGGi | sce:YHR098C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00060 Genomic DNA Translation: AAB68936.1 AJ009784 Genomic DNA Translation: CAA08831.1 BK006934 Genomic DNA Translation: DAA06792.1 |
PIRi | S46728 |
RefSeqi | NP_011966.1, NM_001179228.1 |
3D structure databases
AlphaFoldDBi | P38810 |
SMRi | P38810 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36531, 393 interactors |
ComplexPortali | CPX-1341, SEC23-LST1 COPII cargo recruitment complex |
DIPi | DIP-2949N |
IntActi | P38810, 12 interactors |
MINTi | P38810 |
STRINGi | 4932.YHR098C |
PTM databases
iPTMneti | P38810 |
Proteomic databases
MaxQBi | P38810 |
PaxDbi | P38810 |
PRIDEi | P38810 |
Genome annotation databases
EnsemblFungii | YHR098C_mRNA; YHR098C; YHR098C |
GeneIDi | 856498 |
KEGGi | sce:YHR098C |
Organism-specific databases
SGDi | S000001140, SFB3 |
VEuPathDBi | FungiDB:YHR098C |
Phylogenomic databases
eggNOGi | KOG1984, Eukaryota |
GeneTreei | ENSGT00950000182924 |
HOGENOMi | CLU_004589_1_0_1 |
InParanoidi | P38810 |
OMAi | DRRVHDM |
Enzyme and pathway databases
Reactomei | R-SCE-204005, COPII-mediated vesicle transport R-SCE-5694530, Cargo concentration in the ER R-SCE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
PROi | PR:P38810 |
RNActi | P38810, protein |
Family and domain databases
CDDi | cd01479, Sec24-like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR006900, Sec23/24_helical_dom IPR036175, Sec23/24_helical_dom_sf IPR006896, Sec23/24_trunk_dom IPR012990, Sec23_24_beta_S IPR041742, Sec24-like_trunk_dom IPR036465, vWFA_dom_sf IPR006895, Znf_Sec23_Sec24 IPR036174, Znf_Sec23_Sec24_sf |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit PF08033, Sec23_BS, 1 hit PF04815, Sec23_helical, 1 hit PF04811, Sec23_trunk, 1 hit PF04810, zf-Sec23_Sec24, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF81811, SSF81811, 1 hit SSF82754, SSF82754, 1 hit SSF82919, SSF82919, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SFB3_YEAST | |
Accessioni | P38810Primary (citable) accession number: P38810 Secondary accession number(s): D3DL48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families