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Entry version 155 (07 Apr 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Uncharacterized transporter YHL008C

Gene

YHL008C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • high-affinity secondary active nitrite transmembrane transporter activity Source: GO_Central
  • small molecule sensor activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized transporter YHL008C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YHL008C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001000, YHL008C

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YHL008C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 66CytoplasmicSequence analysisAdd BLAST13
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 113ExtracellularSequence analysisAdd BLAST26
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 165CytoplasmicSequence analysisAdd BLAST31
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 192ExtracellularSequence analysis6
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 218CytoplasmicSequence analysis5
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 245ExtracellularSequence analysis6
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 627CytoplasmicSequence analysisAdd BLAST361

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000947291 – 627Uncharacterized transporter YHL008CAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei305PhosphothreonineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei588PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38750

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38750

PRoteomics IDEntifications database

More...
PRIDEi
P38750

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38750

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36418, 99 interactors

Database of interacting proteins

More...
DIPi
DIP-2601N

Protein interaction database and analysis system

More...
IntActi
P38750, 3 interactors

Molecular INTeraction database

More...
MINTi
P38750

STRING: functional protein association networks

More...
STRINGi
4932.YHL008C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38750, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUGF, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020549_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38750

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPVYGMG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271, Aquaporin-like
IPR000292, For/NO2_transpt
IPR024002, For/NO2_transpt_CS

The PANTHER Classification System

More...
PANTHERi
PTHR30520, PTHR30520, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01226, Form_Nir_trans, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00790, fnt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01005, FORMATE_NITRITE_TP_1, 1 hit
PS01006, FORMATE_NITRITE_TP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDDSNYLTP HETALAVVAT AMKKARLQLD TLLINSILGG VLFSSGSFLL
60 70 80 90 100
VAVYSEDPDI VARNPGIVNL ITGVNFAMGL FYVVMMGADL FNSNILFFSV
110 120 130 140 150
GVLRKAVTIY DLMISWVVSW LGNIAGSLFV SYLFGHLSGI SSQKLWIIGS
160 170 180 190 200
RQIIEQKVSY SFVQTFLKGI ACNFFVCLAI YLQLMAKPIH VKFILMSFPI
210 220 230 240 250
IDFIGIGFTH VVGDMSASFI AMLNGANVSV GKYIWKLLIP ASLGNIVGGL
260 270 280 290 300
FFSAVVPFYL HLVVVERDRK RLSLPEYEAR DEQPELNMDS RVVRIQKNEC
310 320 330 340 350
DDDATETGED LENLTEKGFA SIYNTNHDNS SYFTGRSLNS LRSIPSSVIT
360 370 380 390 400
SDNVTMESDL GEPVQFIPKS NSTTRSPHLG LPHNLPHNHS IKSINRHRIN
410 420 430 440 450
KRHSLRSPPG VFPVRGMGEP LEREKTIEDA TYDPKENELF LRRAETHNSA
460 470 480 490 500
YVKNKKKEDD NLLRLVKTEE DREQKEYEKN GGYNILENKP GTRLEKIITH
510 520 530 540 550
LAENVSSREV TPPILPRTTQ DTFPHNAPAS SPAYTDDAHS LRKANSTTLG
560 570 580 590 600
GLFRAVSKEF HSSKDAESPD DLLKKMAAVG INRNARITAN NVAGIVNLNK
610 620
EDLDSTTRRQ KITEPKNFYN RHTSPQL
Length:627
Mass (Da):69,969
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4413C989A6673FE1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U11581 Genomic DNA Translation: AAB69746.1
AY558102 Genomic DNA Translation: AAS56428.1
BK006934 Genomic DNA Translation: DAA06680.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46820

NCBI Reference Sequences

More...
RefSeqi
NP_011855.1, NM_001179088.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHL008C_mRNA; YHL008C; YHL008C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHL008C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11581 Genomic DNA Translation: AAB69746.1
AY558102 Genomic DNA Translation: AAS56428.1
BK006934 Genomic DNA Translation: DAA06680.1
PIRiS46820
RefSeqiNP_011855.1, NM_001179088.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36418, 99 interactors
DIPiDIP-2601N
IntActiP38750, 3 interactors
MINTiP38750
STRINGi4932.YHL008C

PTM databases

iPTMnetiP38750

Proteomic databases

MaxQBiP38750
PaxDbiP38750
PRIDEiP38750

Genome annotation databases

EnsemblFungiiYHL008C_mRNA; YHL008C; YHL008C
GeneIDi856381
KEGGisce:YHL008C

Organism-specific databases

SGDiS000001000, YHL008C
VEuPathDBiFungiDB:YHL008C

Phylogenomic databases

eggNOGiENOG502QUGF, Eukaryota
HOGENOMiCLU_020549_0_0_1
InParanoidiP38750
OMAiFPVYGMG

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38750
RNActiP38750, protein

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR000292, For/NO2_transpt
IPR024002, For/NO2_transpt_CS
PANTHERiPTHR30520, PTHR30520, 1 hit
PfamiView protein in Pfam
PF01226, Form_Nir_trans, 1 hit
TIGRFAMsiTIGR00790, fnt, 1 hit
PROSITEiView protein in PROSITE
PS01005, FORMATE_NITRITE_TP_1, 1 hit
PS01006, FORMATE_NITRITE_TP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHA8_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38750
Secondary accession number(s): D3DKQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 7, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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