UniProtKB - P38749 (YAP3_YEAST)
AP-1-like transcription factor YAP3
YAP3
Functioni
Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity).
Preferentially binds 5'-TTACTAA-3'.
By similarity4 PublicationsMiscellaneous
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: SGD
- sequence-specific DNA binding Source: SGD
- transcription cis-regulatory region binding Source: GO_Central
GO - Biological processi
- positive regulation of transcription from RNA polymerase II promoter in response to stress Source: GO_Central
- regulation of transcription by RNA polymerase II Source: SGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: AP-1-like transcription factor YAP3 |
Gene namesi | Name:YAP3 Ordered Locus Names:YHL009C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001001, YAP3 |
VEuPathDBi | FungiDB:YHL009C |
Subcellular locationi
Nucleus
- nucleus Source: SGD
- RNA polymerase II transcription regulator complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076523 | 1 – 330 | AP-1-like transcription factor YAP3Add BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 135 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38749 |
PaxDbi | P38749 |
PRIDEi | P38749 |
PTM databases
iPTMneti | P38749 |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with the C-terminal, cytoplasmic tail of the multidrug resistance ABC transporter PDR5.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 36414, 72 interactors |
DIPi | DIP-1668N |
IntActi | P38749, 10 interactors |
MINTi | P38749 |
STRINGi | 4932.YHL009C |
Miscellaneous databases
RNActi | P38749, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 144 – 207 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 114 – 150 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 147 – 168 | Basic motifPROSITE-ProRule annotationAdd BLAST | 22 | |
Regioni | 172 – 207 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 114 – 140 | Polar residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502S2TX, Eukaryota |
HOGENOMi | CLU_071890_0_0_1 |
InParanoidi | P38749 |
OMAi | RSGNENF |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTPSNMDDNT SGFMKFINPQ CQEEDCCIRN SLFQEDSKCI KQQPDLLSEQ
60 70 80 90 100
TAPFPILEDQ CPALNLDRSN NDLLLQNNIS FPKGSDLQAI QLTPISGDYS
110 120 130 140 150
TYVMADNNNN DNDSYSNTNY FSKNNGISPS SRSPSVAHNE NVPDDSKAKK
160 170 180 190 200
KAQNRAAQKA FRERKEARMK ELQDKLLESE RNRQSLLKEI EELRKANTEI
210 220 230 240 250
NAENRLLLRS GNENFSKDIE DDTNYKYSFP TKDEFFTSMV LESKLNHKGK
260 270 280 290 300
YSLKDNEIMK RNTQYTDEAG RHVLTVPATW EYLYKLSEER DFDVTYVMSK
310 320 330
LQGQECCHTH GPAYPRSLID FLVEEATLNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11581 Genomic DNA Translation: AAB69745.1 BK006934 Genomic DNA Translation: DAA06677.1 |
PIRi | S46819 |
RefSeqi | NP_011854.1, NM_001179089.1 |
Genome annotation databases
EnsemblFungii | YHL009C_mRNA; YHL009C; YHL009C |
GeneIDi | 856377 |
KEGGi | sce:YHL009C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11581 Genomic DNA Translation: AAB69745.1 BK006934 Genomic DNA Translation: DAA06677.1 |
PIRi | S46819 |
RefSeqi | NP_011854.1, NM_001179089.1 |
3D structure databases
SMRi | P38749 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36414, 72 interactors |
DIPi | DIP-1668N |
IntActi | P38749, 10 interactors |
MINTi | P38749 |
STRINGi | 4932.YHL009C |
PTM databases
iPTMneti | P38749 |
Proteomic databases
MaxQBi | P38749 |
PaxDbi | P38749 |
PRIDEi | P38749 |
Genome annotation databases
EnsemblFungii | YHL009C_mRNA; YHL009C; YHL009C |
GeneIDi | 856377 |
KEGGi | sce:YHL009C |
Organism-specific databases
SGDi | S000001001, YAP3 |
VEuPathDBi | FungiDB:YHL009C |
Phylogenomic databases
eggNOGi | ENOG502S2TX, Eukaryota |
HOGENOMi | CLU_071890_0_0_1 |
InParanoidi | P38749 |
OMAi | RSGNENF |
Miscellaneous databases
PROi | PR:P38749 |
RNActi | P38749, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YAP3_YEAST | |
Accessioni | P38749Primary (citable) accession number: P38749 Secondary accession number(s): D3DKQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families