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UniProtKB - P38739 (WSC4_YEAST)
Protein
Cell wall integrity and stress response component 4
Gene
WSC4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
GO - Molecular functioni
- protein transmembrane transporter activity Source: SGD
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- protein targeting to ER Source: SGD
- protein targeting to membrane Source: SGD
- response to heat Source: SGD
Keywordsi
Biological process | Cell wall biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Cell wall integrity and stress response component 4 |
Gene namesi | Name:WSC4 Ordered Locus Names:YHL028W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001020, WSC4 |
VEuPathDBi | FungiDB:YHL028W |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000041486 | 27 – 605 | Cell wall integrity and stress response component 4Add BLAST | 579 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 386 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 398 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 553 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 583 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P38739 |
PaxDbi | P38739 |
PRIDEi | P38739 |
PTM databases
iPTMneti | P38739 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36394, 32 interactors |
IntActi | P38739, 3 interactors |
STRINGi | 4932.YHL028W |
Miscellaneous databases
RNActi | P38739, protein |
Structurei
3D structure databases
AlphaFoldDBi | P38739 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 110 | WSCPROSITE-ProRule annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 151 – 305 | DisorderedSequence analysisAdd BLAST | 155 | |
Regioni | 381 – 404 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 494 – 521 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 495 – 521 | Polar residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4157, Eukaryota |
HOGENOMi | CLU_024893_2_1_1 |
InParanoidi | P38739 |
OMAi | GYWDSPG |
Family and domain databases
InterProi | View protein in InterPro IPR002889, WSC_carb-bd |
SMARTi | View protein in SMART SM00321, WSC, 1 hit |
PROSITEi | View protein in PROSITE PS51212, WSC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P38739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQTSMVSAKV SIWLVCSVIC SSLVRATQSV CSSQNTATTD GVRNQFQSNG
60 70 80 90 100
WCSNNCAGHQ FAIVQGFMCW CSDSEPSTQT SVGDCSGTCP GYGYEDCGNA
110 120 130 140 150
DKDLFGYIYL GQTPLSSVQS VETSTESSVY VSSSSITSSS STSIVDTTTI
160 170 180 190 200
SPTLTSTSTT PLTTASTSTT PSTDITSALP TTTSTKLSTS IPTSTTSSTS
210 220 230 240 250
TTTSTSSSTS TTVSVTSSTS TTTSTTSSTL ISTSTSSSSS STPTTTSSAP
260 270 280 290 300
ISTSTTSSTS TSTSTTSPTS SSAPTSSSNT TPTSTTFTTT SPSTAPSSTT
310 320 330 340 350
VTYTSTTASP ITSTITSVNL QTSLKYSVIT VTSVHTMDTN ISEITSRYLT
360 370 380 390 400
MKKVITQIYS STLGATPTSA VATTSASVGG RITNNNNSNT TNSNTPTNKS
410 420 430 440 450
TEKKGYWDSP GKIAATFVVV GVVCLVIICI LIYLIHHYRT RPARKAQDFE
460 470 480 490 500
NEYQSKFYQS KYPNEVTTTT LHTPSPSSNS TFSTPRLIYT DEKGQIMSES
510 520 530 540 550
PSPRQSTYSL TAGSPPNDPS TLASPFHDPI LPRRTSTFLH SPIQKQHEKM
560 570 580 590 600
ESNVTLGEDT VLVDQRLDPS KMLNTLANDD ATNHSTISLS DNVDYSRRVL
RLMNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11583 Genomic DNA Translation: AAB65040.1 BK006934 Genomic DNA Translation: DAA06657.1 |
PIRi | S48940 |
RefSeqi | NP_011835.1, NM_001179108.1 |
Genome annotation databases
EnsemblFungii | YHL028W_mRNA; YHL028W; YHL028W |
GeneIDi | 856357 |
KEGGi | sce:YHL028W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11583 Genomic DNA Translation: AAB65040.1 BK006934 Genomic DNA Translation: DAA06657.1 |
PIRi | S48940 |
RefSeqi | NP_011835.1, NM_001179108.1 |
3D structure databases
AlphaFoldDBi | P38739 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36394, 32 interactors |
IntActi | P38739, 3 interactors |
STRINGi | 4932.YHL028W |
PTM databases
iPTMneti | P38739 |
Proteomic databases
MaxQBi | P38739 |
PaxDbi | P38739 |
PRIDEi | P38739 |
Genome annotation databases
EnsemblFungii | YHL028W_mRNA; YHL028W; YHL028W |
GeneIDi | 856357 |
KEGGi | sce:YHL028W |
Organism-specific databases
SGDi | S000001020, WSC4 |
VEuPathDBi | FungiDB:YHL028W |
Phylogenomic databases
eggNOGi | KOG4157, Eukaryota |
HOGENOMi | CLU_024893_2_1_1 |
InParanoidi | P38739 |
OMAi | GYWDSPG |
Miscellaneous databases
PROi | PR:P38739 |
RNActi | P38739, protein |
Family and domain databases
InterProi | View protein in InterPro IPR002889, WSC_carb-bd |
SMARTi | View protein in SMART SM00321, WSC, 1 hit |
PROSITEi | View protein in PROSITE PS51212, WSC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WSC4_YEAST | |
Accessioni | P38739Primary (citable) accession number: P38739 Secondary accession number(s): D3DKU0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names