Cell wall integrity and stress response component 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein transmembrane transporter activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation."
    Mamoun C.B., Beckerich J.M., Gaillardin C., Kepes F.
    J Biol Chem 274:11296-11302(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell wall organization Source: UniProtKB-KW
• protein targeting to ER Source: SGDInferred from mutant phenotypeⁱ
  • "Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation."
    Mamoun C.B., Beckerich J.M., Gaillardin C., Kepes F.
    J Biol Chem 274:11296-11302(1999) [PubMed] [Europe PMC] [Abstract]
• protein targeting to membrane Source: SGDInferred from mutant phenotypeⁱ
  • "Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation."
    Mamoun C.B., Beckerich J.M., Gaillardin C., Kepes F.
    J Biol Chem 274:11296-11302(1999) [PubMed] [Europe PMC] [Abstract]
• response to heat Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae."
    Zu T., Verna J., Ballester R.
    Mol Genet Genomics 266:142-155(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MQTSMVSAKV SIWLVCSVIC SSLVRATQSV CSSQNTATTD GVRNQFQSNG 
        60         70         80         90        100
WCSNNCAGHQ FAIVQGFMCW CSDSEPSTQT SVGDCSGTCP GYGYEDCGNA 
       110        120        130        140        150
DKDLFGYIYL GQTPLSSVQS VETSTESSVY VSSSSITSSS STSIVDTTTI 
       160        170        180        190        200
SPTLTSTSTT PLTTASTSTT PSTDITSALP TTTSTKLSTS IPTSTTSSTS 
       210        220        230        240        250
TTTSTSSSTS TTVSVTSSTS TTTSTTSSTL ISTSTSSSSS STPTTTSSAP 
       260        270        280        290        300
ISTSTTSSTS TSTSTTSPTS SSAPTSSSNT TPTSTTFTTT SPSTAPSSTT 
       310        320        330        340        350
VTYTSTTASP ITSTITSVNL QTSLKYSVIT VTSVHTMDTN ISEITSRYLT 
       360        370        380        390        400
MKKVITQIYS STLGATPTSA VATTSASVGG RITNNNNSNT TNSNTPTNKS 
       410        420        430        440        450
TEKKGYWDSP GKIAATFVVV GVVCLVIICI LIYLIHHYRT RPARKAQDFE 
       460        470        480        490        500
NEYQSKFYQS KYPNEVTTTT LHTPSPSSNS TFSTPRLIYT DEKGQIMSES 
       510        520        530        540        550
PSPRQSTYSL TAGSPPNDPS TLASPFHDPI LPRRTSTFLH SPIQKQHEKM 
       560        570        580        590        600
ESNVTLGEDT VLVDQRLDPS KMLNTLANDD ATNHSTISLS DNVDYSRRVL 

RLMNE                                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome VIII
   Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names