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Protein

Golgi SNAP receptor complex member 1

Gene

GOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Rescues alpha-factor maturation defects.3 Publications

Caution

Formerly referred to as a v-SNARE.Curated

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31051-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 1
Alternative name(s):
Golgi SNARE protein 1
Protein transport protein GOS1
Gene namesi
Name:GOS1
Ordered Locus Names:YHL031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL031C
SGDiS000001023 GOS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 204CytoplasmicSequence analysisAdd BLAST203
Transmembranei205 – 222Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST18
Topological domaini223VesicularSequence analysis1

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Lack of late Golgi SNARE proteins, TLG1 and TLG2. Spores are temperature sensitive and fail to germinate at 37 degrees Celsius. 10 to 20% of cells possess a variety of aberrant structures, including fragmentation of the vacuole, a common occurrence in secretory defects, and substantial accumulation of membranes in some cells. These structures are considered to be abnormal Golgi remnants. Endoplasmic reticulum (ER) retention defective, erd phenotype, which is characterized by hypersecretion of ER-resident proteins. This results from a defect in retrograde directed vesicles. Severely compromised viability when another Golgi protein, COY1P is overexpressed. Incomplete maturation of alpha-factor via defective localization of KEX2.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002125572 – 223Golgi SNAP receptor complex member 1Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei164PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP38736
PaxDbiP38736
PRIDEiP38736

PTM databases

iPTMnetiP38736

Interactioni

Subunit structurei

Component of several multiprotein Golgi SNARE complexes. Identified in a Golgi SNARE complex consisting of t-SNARES SED5, YKT6, and the v-SNARE SFT1. Interacts with BET1. Interacts with BOS1. Interacts with SEC22. Interacts with PEP12. Interacts with self.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SED5Q015905EBI-24365,EBI-16930

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36391, 492 interactors
ComplexPortaliCPX-1855 Golgi SNARE complex SED5-GOS1-YKT6-SFT1
DIPiDIP-2490N
IntActiP38736, 9 interactors
MINTiP38736
STRINGi4932.YHL031C

Structurei

3D structure databases

ProteinModelPortaliP38736
SMRiP38736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GOSR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008688
HOGENOMiHOG000207760
InParanoidiP38736
KOiK08495
OMAiINDKMAE
OrthoDBiEOG092C5G0E

Family and domain databases

InterProiView protein in InterPro
IPR023601 Golgi_SNAP_su1
PANTHERiPTHR21094 PTHR21094, 1 hit
PIRSFiPIRSF027109 Golgi_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38736-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQPSFVTI RGKAISLETQ TESLLSKYST FAQTTSSEQT GQEKKIDKQL
60 70 80 90 100
EGILGQRQDV IDSLTQICDS NPAISASKLS QLHRHKEILQ DHWKSFRNIR
110 120 130 140 150
SSIQQERNRL NLLFSVKNDI ANSTTDAPAP IGDADEYIQN ETRRIDQSNN
160 170 180 190 200
VVDRLISQAW ETRSQFHSQS NVLNTANNKV LQTLQRIPGV NQLIMKINTR
210 220
RKKNAFVLAT ITTLCILFLF FTW
Length:223
Mass (Da):25,395
Last modified:February 1, 1995 - v1
Checksum:i1E833249CCC306C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA Translation: AAB65043.1
BK006934 Genomic DNA Translation: DAA06654.1
PIRiS48937
RefSeqiNP_011832.1, NM_001179111.1

Genome annotation databases

EnsemblFungiiYHL031C; YHL031C; YHL031C
GeneIDi856354
KEGGisce:YHL031C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA Translation: AAB65043.1
BK006934 Genomic DNA Translation: DAA06654.1
PIRiS48937
RefSeqiNP_011832.1, NM_001179111.1

3D structure databases

ProteinModelPortaliP38736
SMRiP38736
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36391, 492 interactors
ComplexPortaliCPX-1855 Golgi SNARE complex SED5-GOS1-YKT6-SFT1
DIPiDIP-2490N
IntActiP38736, 9 interactors
MINTiP38736
STRINGi4932.YHL031C

PTM databases

iPTMnetiP38736

Proteomic databases

MaxQBiP38736
PaxDbiP38736
PRIDEiP38736

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL031C; YHL031C; YHL031C
GeneIDi856354
KEGGisce:YHL031C

Organism-specific databases

EuPathDBiFungiDB:YHL031C
SGDiS000001023 GOS1

Phylogenomic databases

GeneTreeiENSGT00390000008688
HOGENOMiHOG000207760
InParanoidiP38736
KOiK08495
OMAiINDKMAE
OrthoDBiEOG092C5G0E

Enzyme and pathway databases

BioCyciYEAST:G3O-31051-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Miscellaneous databases

PROiPR:P38736

Family and domain databases

InterProiView protein in InterPro
IPR023601 Golgi_SNAP_su1
PANTHERiPTHR21094 PTHR21094, 1 hit
PIRSFiPIRSF027109 Golgi_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR1_YEAST
AccessioniPrimary (citable) accession number: P38736
Secondary accession number(s): D3DKT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
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Main funding by: National Institutes of Health

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