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UniProtKB - P38727 (YHE4_YEAST)

Entry version 127 (25 May 2022)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

DUP240 protein YHL044W

Gene

YHL044W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUP240 protein YHL044W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YHL044W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000001036, YHL044W

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YHL044W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72ExtracellularSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 235CytoplasmicSequence analysisAdd BLAST142

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002075331 – 235DUP240 protein YHL044WAdd BLAST235

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P38727

PRoteomics IDEntifications database

More...PRIDEi		P38727

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts according to large scale protein interaction studies with BZZ1, SRB4 and SUA7.

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		36380, 18 interactors

Database of interacting proteins

More...DIPi		DIP-2089N

STRING: functional protein association networks

More...STRINGi		4932.YHL044W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P38727, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P38727

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081384_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P38727

Identification of Orthologs from Complete Genome Data

More...OMAi		AEVITHK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001142, DUP/COS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00674, DUP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38727-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSELLISNS KPRPEGLRKL CEGETVILPR DITPSKCAYF LKQNIVFISY 
        60         70         80         90        100
IFIHIIITII LNRLALSAHG NTLIIILAAL LITISLFLLL LLPYLSCSRY 
       110        120        130        140        150
KLRCLDDDCK FKLLAEVITH KPNMDLSTWD RIAYDMNQFV YDRRICADRS 
       160        170        180        190        200
FFYDGSYCYQ VFKKLVATPY LVNSNMNSIY ADLEMRSNGA TNINDSGNSS 
       210        220        230 
LHIELGTYIF KALAVFRNSV DKYWEDKYPE MGVTV
Length:235
Mass (Da):26,972
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A789B602087D928
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti9N → D in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti47F → L in strain: CLIB 219, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. 1 Publication1
Natural varianti75I → V in strain: CLIB 95, CLIB 382, CLIB 556 haplotype Ha1, K1, R12, R13, YIIc12 haplotype Ha1 and YIIc17 haplotype Ha1. 1 Publication1
Natural varianti77L → F in strain: CLIB 388. 1
Natural varianti86L → P in strain: CLIB 388. 1 Publication1
Natural varianti96S → N in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti103R → T in strain: CLIB 388, CLIB 410, CLIB 556 haplotype Ha2, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. 1 Publication1
Natural varianti124M → V in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti145I → M in strain: R12 haplotype Ha2. 1 Publication1
Natural varianti157Y → S in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti160Q → R in strain: CLIB 556 haplotype Ha1. 1 Publication1
Natural varianti180Y → D in strain: CLIB 95, CLIB 382, K1, R12, R13, YIIc12 haplotype Ha1 and YIIc17 haplotype Ha1. 1 Publication1
Natural varianti189G → A in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti225 – 235EDKYPEMGVTV → RISIQRWGTQF in strain: CLIB 630. Add BLAST11
Natural varianti233V → D in strain: CLIB 219, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. 1 Publication1
Natural varianti234T → I in strain: CLIB 413 haplotype Ha1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ585565 Genomic DNA Translation: CAE52085.1
AJ585566 Genomic DNA Translation: CAE52086.1
AJ585567 Genomic DNA Translation: CAE52087.1
AJ585568 Genomic DNA Translation: CAE52088.1
AJ585569 Genomic DNA Translation: CAE52089.1
AJ585570 Genomic DNA Translation: CAE52090.1
AJ585571 Genomic DNA Translation: CAE52091.1
AJ585572 Genomic DNA Translation: CAE52092.1
AJ585573 Genomic DNA Translation: CAE52093.1
AJ585574 Genomic DNA Translation: CAE52094.1
AJ585575 Genomic DNA Translation: CAE52095.1
AJ585576 Genomic DNA Translation: CAE52096.1
AJ585577 Genomic DNA Translation: CAE52097.1
AJ585578 Genomic DNA Translation: CAE52098.1
AJ585579 Genomic DNA Translation: CAE52099.1
AJ585580 Genomic DNA Translation: CAE52100.1
AJ585581 Genomic DNA Translation: CAE52101.1
AJ585582 Genomic DNA Translation: CAE52102.1
AJ585755 Genomic DNA Translation: CAE52275.1
U11583 Genomic DNA Translation: AAB65056.1
BK006934 Genomic DNA Translation: DAA06643.1

Protein sequence database of the Protein Information Resource

More...PIRi		S48924

NCBI Reference Sequences

More...RefSeqi		NP_011819.1, NM_001179124.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YHL044W_mRNA; YHL044W; YHL044W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		856341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YHL044W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585565 Genomic DNA Translation: CAE52085.1
AJ585566 Genomic DNA Translation: CAE52086.1
AJ585567 Genomic DNA Translation: CAE52087.1
AJ585568 Genomic DNA Translation: CAE52088.1
AJ585569 Genomic DNA Translation: CAE52089.1
AJ585570 Genomic DNA Translation: CAE52090.1
AJ585571 Genomic DNA Translation: CAE52091.1
AJ585572 Genomic DNA Translation: CAE52092.1
AJ585573 Genomic DNA Translation: CAE52093.1
AJ585574 Genomic DNA Translation: CAE52094.1
AJ585575 Genomic DNA Translation: CAE52095.1
AJ585576 Genomic DNA Translation: CAE52096.1
AJ585577 Genomic DNA Translation: CAE52097.1
AJ585578 Genomic DNA Translation: CAE52098.1
AJ585579 Genomic DNA Translation: CAE52099.1
AJ585580 Genomic DNA Translation: CAE52100.1
AJ585581 Genomic DNA Translation: CAE52101.1
AJ585582 Genomic DNA Translation: CAE52102.1
AJ585755 Genomic DNA Translation: CAE52275.1
U11583 Genomic DNA Translation: AAB65056.1
BK006934 Genomic DNA Translation: DAA06643.1
PIRiS48924
RefSeqiNP_011819.1, NM_001179124.1

3D structure databases

AlphaFoldDBiP38727
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi36380, 18 interactors
DIPiDIP-2089N
STRINGi4932.YHL044W

Proteomic databases

PaxDbiP38727
PRIDEiP38727

Genome annotation databases

EnsemblFungiiYHL044W_mRNA; YHL044W; YHL044W
GeneIDi856341
KEGGisce:YHL044W

Organism-specific databases

SGDiS000001036, YHL044W
VEuPathDBiFungiDB:YHL044W

Phylogenomic databases

GeneTreeiENSGT00940000176285
HOGENOMiCLU_081384_1_0_1
InParanoidiP38727
OMAiAEVITHK

Miscellaneous databases

Protein Ontology

More...PROi		PR:P38727
RNActiP38727, protein

Family and domain databases

InterProiView protein in InterPro
IPR001142, DUP/COS
PfamiView protein in Pfam
PF00674, DUP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHE4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38727
Secondary accession number(s): D3DKS6
, Q70D60, Q70DF5, Q70DF7, Q70DF9, Q70DG3, Q70DG4, Q70DG5, Q70DG6, Q70DG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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