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UniProtKB - P38724 (ARN2_YEAST)
Protein
Siderophore iron transporter ARN2
Gene
ARN2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.
2 PublicationsGO - Molecular functioni
- siderophore transmembrane transporter activity Source: SGD
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cellular iron ion homeostasis Source: SGD
- siderophore metabolic process Source: SGD
- siderophore transport Source: SGD
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Protein family/group databases
TCDBi | 2.A.1.16.3, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Siderophore iron transporter ARN2Alternative name(s): Triacetylfusarinine C permease Triacetylfusarinine C transporter 1 |
Gene namesi | Name:ARN2 Synonyms:TAF1 Ordered Locus Names:YHL047C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001039, ARN2 |
VEuPathDBi | FungiDB:YHL047C |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein By similarity
Endosome
- endosome Source: GO_Central
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Vacuole
- fungal-type vacuole Source: SGD
- vacuolar membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 71 – 93 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 106 – 128 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 135 – 152 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 162 – 184 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 191 – 213 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 223 – 245 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 286 – 308 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 318 – 335 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 355 – 377 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 392 – 414 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 421 – 438 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 448 – 470 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 491 – 513 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 561 – 578 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084863 | 1 – 620 | Siderophore iron transporter ARN2Add BLAST | 620 |
Proteomic databases
PaxDbi | P38724 |
PRIDEi | P38724 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36378, 23 interactors |
DIPi | DIP-7479N |
STRINGi | 4932.YHL047C |
Miscellaneous databases
RNActi | P38724, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000176305 |
HOGENOMi | CLU_012970_2_1_1 |
InParanoidi | P38724 |
OMAi | VEWKELQ |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P38724-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS
60 70 80 90 100
LIIRKSELMA KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS
110 120 130 140 150
YSAHSLISTV SVIVLMISAV SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI
160 170 180 190 200
IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV LMLSDNSSLK WRLFYTLIPS
210 220 230 240 250
WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP LILCMLHMRW
260 270 280 290 300
KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL
310 320 330 340 350
VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL
360 370 380 390 400
KDRGVWAPLG IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF
410 420 430 440 450
VTAVVAPFLG LIVTRSSRLK SYIIFGGSLY FITMGLFYRY RSGQDADGGI
460 470 480 490 500
IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN MATVTALNYT VFRIGGAVAA
510 520 530 540 550
AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP WGTPVRSAMV
560 570 580 590 600
EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK
610 620
EDDPINDWIA KRFAKALGRS
Sequence cautioni
The sequence AAB65059 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11583 Genomic DNA Translation: AAB65059.1 Frameshift. BK006934 Genomic DNA Translation: DAA06641.2 |
PIRi | S48921 |
RefSeqi | NP_011816.2, NM_001179127.2 |
Genome annotation databases
EnsemblFungii | YHL047C_mRNA; YHL047C; YHL047C |
GeneIDi | 856338 |
KEGGi | sce:YHL047C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11583 Genomic DNA Translation: AAB65059.1 Frameshift. BK006934 Genomic DNA Translation: DAA06641.2 |
PIRi | S48921 |
RefSeqi | NP_011816.2, NM_001179127.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36378, 23 interactors |
DIPi | DIP-7479N |
STRINGi | 4932.YHL047C |
Protein family/group databases
TCDBi | 2.A.1.16.3, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P38724 |
PRIDEi | P38724 |
Genome annotation databases
EnsemblFungii | YHL047C_mRNA; YHL047C; YHL047C |
GeneIDi | 856338 |
KEGGi | sce:YHL047C |
Organism-specific databases
SGDi | S000001039, ARN2 |
VEuPathDBi | FungiDB:YHL047C |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000176305 |
HOGENOMi | CLU_012970_2_1_1 |
InParanoidi | P38724 |
OMAi | VEWKELQ |
Miscellaneous databases
PROi | PR:P38724 |
RNActi | P38724, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARN2_YEAST | |
Accessioni | P38724Primary (citable) accession number: P38724 Secondary accession number(s): D3DKS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | September 29, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families