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Entry version 153 (07 Apr 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Membrane-anchored lipid-binding protein SIP3

Gene

SIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in sterol transfer between intracellular membranes.

1 Publication

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.198.1.2, the membrane-anchored lipid-binding protein (lam) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-anchored lipid-binding protein SIP31 Publication
Alternative name(s):
Lipid transfer protein anchored at membrane contact sites 31 Publication
SNF1-interacting protein 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIP31 Publication
Synonyms:LAM31 Publication
Ordered Locus Names:YNL257CImported
ORF Names:N0844
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005201, SIP3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL257C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1066Cytoplasmic2 PublicationsAdd BLAST1066
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1067 – 1087HelicalSequence analysisAdd BLAST21
Topological domaini1088 – 1229Lumenal1 PublicationAdd BLAST142

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977651 – 1229Membrane-anchored lipid-binding protein SIP3Add BLAST1229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1206N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38717

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38717

PRoteomics IDEntifications database

More...
PRIDEi
P38717

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38717

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SNF1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35582, 67 interactors

Database of interacting proteins

More...
DIPi
DIP-780N

STRING: functional protein association networks

More...
STRINGi
4932.YNL257C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38717, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38717

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 423PHPROSITE-ProRule annotationAdd BLAST115
Domaini771 – 976VAStPROSITE-ProRule annotationAdd BLAST206

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The VASt domain bind sterols.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU87, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001720_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38717

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEVKTKS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07609, BAR_SIP3_fungi, 1 hit
cd13280, PH_SIP3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039463, Sip3/Lam1_BAR
IPR042067, Sip3_PH
IPR031968, VASt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF16016, VASt, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS51778, VAST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38717-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVHGRDPKK RQLRLISVAF KEASIDSPSF RASVNFFQTR VDALEDWIEK
60 70 80 90 100
TVDFFDQKYK VSFEDFRRAK ETLLSQLLPP PALLSNGFVS NQSFTPRLID
110 120 130 140 150
SFNKDYYDFS MKLLQIVKGD DSSHSTALLE LMTTAIEPYR NVRKNFDFYQ
160 170 180 190 200
GKYDSMLASY QAIRISKTSL EPSSIKSDAL QLFEVQKNYL KASLDLISAI
210 220 230 240 250
SAVKLSLDKF ILESMKVLKS RSIFITKDSG RKIDLSPCIN EYLDNYAIWV
260 270 280 290 300
ENSIEGSKVL DSDISNAKKQ AYRYTLKRIT PSSDTSDYNI RSIHSSKLLS
310 320 330 340 350
KDTQVPPKSP EKSGWLYMKT QVGKPTREIW VRRWCFLKNA VFGMFLLSPS
360 370 380 390 400
KTYVEETDKF GVFLTNVRYD PEEDRKFCFE VKIFGNKVTE AHDNMSKDIT
410 420 430 440 450
LVFQTSNYLD LKSWLIAFEA TKKYVMSIQH DSLEYELAFK RFSPKFFEFA
460 470 480 490 500
SSTTTSIDQL ITTFDKETES LYETLNCSIS EYDILTLGEE KVFQFQMPTT
510 520 530 540 550
PISTKMTQLA ILSNFLTKGS WFPNAVLANI WGTTDWSEYT ILPGKGKKPS
560 570 580 590 600
SLLTIDGKRL PIRNSTIYPQ YYSNELKVLD LQFKSLVFSP DQRLEKLPEE
610 620 630 640 650
LLLFKFEALW CPNKKQKFSA TCFCTKDYIY CYMNSMEFIC LTKISLSEIV
660 670 680 690 700
SVEADRSSKK TLKLYDASGL QMKAIVLFSD YKLIASKLQY LLENKAIKNP
710 720 730 740 750
NSNEEILVKF EQMEKESQEK KQEELYKIEQ ENSFDRKATS VSKIIKSRVT
760 770 780 790 800
FWEMSDDAST LLNRLKKLQT EYSITYNHEY EISSKGLAHI LFGDKSNAFP
810 820 830 840 850
KCLFLARKDG EEHGKRFWYK NKDINGKSQL VRKIPFRLDM TGNFLNTGKY
860 870 880 890 900
HRDKESKMIF ATQRIVKIVD NKYYEVDLDP FFVKVPFCHL LKLSIKFVIT
910 920 930 940 950
ESYDVDNHLE IKLNMTASSS SLHVLYKLEY IDSRTGKTIE KLSLAEIICQ
960 970 980 990 1000
TWALKFAHSE FLLIRRVLRY YLEKIGKHGK VIKAIKLCGI LGVLSNKSEE
1010 1020 1030 1040 1050
PATEKNGNSK ESESMQYDIR YSCTILFLVF IKLMVYRVTN LTFVFFRILI
1060 1070 1080 1090 1100
GILLLCAEKF SRINRMMVVG LLASIMINIL LSEKASVPYW SIKRAEKLFH
1110 1120 1130 1140 1150
DRLGSDKFTM QRAIYISDSD LLSSQLSVPS NNPIFEKFSE DNFNKDYQYS
1160 1170 1180 1190 1200
ETRKQLAMRR NELLIELRIL QDMEKQLVHD DYEKFLLEEV NKCSMVSIEM
1210 1220
TDLWFNDTQL QNYCSICNEE LEKLRPPIT
Length:1,229
Mass (Da):142,820
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i977995219282CD65
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03376 Genomic DNA Translation: AAA17885.1
X96722 Genomic DNA Translation: CAA65487.1
Z71533 Genomic DNA Translation: CAA96164.1
BK006947 Genomic DNA Translation: DAA10302.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S42391

NCBI Reference Sequences

More...
RefSeqi
NP_014142.1, NM_001183095.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL257C_mRNA; YNL257C; YNL257C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL257C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03376 Genomic DNA Translation: AAA17885.1
X96722 Genomic DNA Translation: CAA65487.1
Z71533 Genomic DNA Translation: CAA96164.1
BK006947 Genomic DNA Translation: DAA10302.1
PIRiS42391
RefSeqiNP_014142.1, NM_001183095.1

3D structure databases

SMRiP38717
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35582, 67 interactors
DIPiDIP-780N
STRINGi4932.YNL257C

Protein family/group databases

TCDBi9.B.198.1.2, the membrane-anchored lipid-binding protein (lam) family

PTM databases

iPTMnetiP38717

Proteomic databases

MaxQBiP38717
PaxDbiP38717
PRIDEiP38717

Genome annotation databases

EnsemblFungiiYNL257C_mRNA; YNL257C; YNL257C
GeneIDi855464
KEGGisce:YNL257C

Organism-specific databases

SGDiS000005201, SIP3
VEuPathDBiFungiDB:YNL257C

Phylogenomic databases

eggNOGiENOG502QU87, Eukaryota
GeneTreeiENSGT00940000154453
HOGENOMiCLU_001720_0_0_1
InParanoidiP38717
OMAiFEVKTKS

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38717
RNActiP38717, protein

Family and domain databases

CDDicd07609, BAR_SIP3_fungi, 1 hit
cd13280, PH_SIP3, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039463, Sip3/Lam1_BAR
IPR042067, Sip3_PH
IPR031968, VASt
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF16016, VASt, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS51778, VAST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIP3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38717
Secondary accession number(s): D6W0T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 7, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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