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Entry version 171 (31 Jul 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Oxysterol-binding protein homolog 3

Gene

OSH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31122-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-192105 Synthesis of bile acids and bile salts

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSH3
Ordered Locus Names:YHR073W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YHR073W

Saccharomyces Genome Database

More...
SGDi
S000001115 OSH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003891 – 996Oxysterol-binding protein homolog 3Add BLAST996

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei190PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei210PhosphothreonineCombined sources1
Modified residuei323PhosphothreonineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei325PhosphothreonineCombined sources1
Modified residuei352PhosphothreonineCombined sources1
Modified residuei605PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38713

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38713

PRoteomics IDEntifications database

More...
PRIDEi
P38713

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38713

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36507, 142 interactors

Database of interacting proteins

More...
DIPi
DIP-2148N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P38713

Protein interaction database and analysis system

More...
IntActi
P38713, 10 interactors

Molecular INTeraction database

More...
MINTi
P38713

STRING: functional protein association networks

More...
STRINGi
4932.YHR073W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1996
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38713

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 315PHPROSITE-ProRule annotationAdd BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi514 – 520FFAT7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FFAT motif is required for interaction with SCS2 and proper localization of the protein.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000193697

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38713

KEGG Orthology (KO)

More...
KOi
K20463

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKCEADK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036598 GOLD_dom_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR041680 PH_8
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10972 PTHR10972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF15409 PH_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101576 SSF101576, 1 hit
SSF144000 SSF144000, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METIDIQNRS FVVRWVKCGR GDVINYQIKP LKKSIEVGIY KKLKSSVDDH
60 70 80 90 100
ASAVHIAPDT KTLLDYTTKS LLHKGSSSNI EEHHRRSSQH SHSSSNGSDN
110 120 130 140 150
KRKERSYSSL SISGIQQQSQ EIPLREKLSA SGFTLVKRVG NVSGNTMVQG
160 170 180 190 200
DLEVKDTDYY YAFILDNSSS KNAKKKILFN ASVINGDNQS MISTRSTPPA
210 220 230 240 250
RPTALSRTST QQDMLFRVGQ GRYLQGYLLK KRRKRLQGFK KRFFTLDFRY
260 270 280 290 300
GTLSYYLNDH NQTCRGEIVI SLSSVSANKK DKIIIIDSGM EVWVLKATTK
310 320 330 340 350
ENWQSWVDAL QTCFDDQFED KDTSTLEENP DILDDDKEVI NKSSPQDHDH
360 370 380 390 400
LTPTATTKSA LSHRQHTQKD MDDIYVPLPS ESYATFSMNL RLIQQRLEQC
410 420 430 440 450
KKDSLSYKPT TLHQRSEGLN GTHSSSSVFT NNRVSSFNHS SSGMTSSDSL
460 470 480 490 500
ASEEVPSNKT YIEHALYNQL ADLEVFVSRF VTQGEVLFKD HQILCKKAKD
510 520 530 540 550
TRVSLTSYLS ENDEFFDAEE EISRGVIILP DTEDDINNIV EETPLLGKSD
560 570 580 590 600
QNEFTKEVQL SGSEQIASSS VESYTTNDEN HSRKHLKNRH KNRRRGHPHH
610 620 630 640 650
QKTKSAQSST ETFTSKDLFA LSYPKSVTRR NDIPEAAASP PSLLSFLRKN
660 670 680 690 700
VGKDLSSIAM PVTSNEPISI LQLISETFEY APLLTKATQR PDPITFVSAF
710 720 730 740 750
AISFLSIYRD KTRTLRKPFN PLLAETFELI REDMGFRLIS EKVSHRPPVF
760 770 780 790 800
AFFAEHLDWE CSYTVTPSQK FWGKSIELNN EGILRLKFKT TGELFEWTQP
810 820 830 840 850
TTILKNLIAG ERYMEPVNEF EVHSSKGDKS HILFDKAGMF SGRSEGFKVS
860 870 880 890 900
IIPPPSSNRK KETLAGKWTQ SLANETTHET IWEVGDLVSN PKKKYGFTKF
910 920 930 940 950
TANLNEITEI EKGNLPPTDS RLRPDIRAYE EGNVDKAEEW KLKLEQLQRE
960 970 980 990
RRNKGQDVEP KYFEKVSKNE WKYITGPKSY WERRKKHDWS DISQLW
Length:996
Mass (Da):113,760
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1AD1210EFFB9AFE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10556 Genomic DNA Translation: AAB68890.1
BK006934 Genomic DNA Translation: DAA06767.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46812

NCBI Reference Sequences

More...
RefSeqi
NP_011940.1, NM_001179203.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHR073W_mRNA; YHR073W_mRNA; YHR073W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856472

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHR073W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA Translation: AAB68890.1
BK006934 Genomic DNA Translation: DAA06767.1
PIRiS46812
RefSeqiNP_011940.1, NM_001179203.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IAPX-ray2.30A/B221-315[»]
4IC4X-ray1.50A605-996[»]
4INQX-ray2.20A605-996[»]
SMRiP38713
ModBaseiSearch...

Protein-protein interaction databases

BioGridi36507, 142 interactors
DIPiDIP-2148N
ELMiP38713
IntActiP38713, 10 interactors
MINTiP38713
STRINGi4932.YHR073W

PTM databases

iPTMnetiP38713

Proteomic databases

MaxQBiP38713
PaxDbiP38713
PRIDEiP38713

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR073W_mRNA; YHR073W_mRNA; YHR073W
GeneIDi856472
KEGGisce:YHR073W

Organism-specific databases

EuPathDBiFungiDB:YHR073W
SGDiS000001115 OSH3

Phylogenomic databases

HOGENOMiHOG000193697
InParanoidiP38713
KOiK20463
OMAiGKCEADK

Enzyme and pathway databases

BioCyciYEAST:G3O-31122-MONOMER
ReactomeiR-SCE-192105 Synthesis of bile acids and bile salts

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38713

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036598 GOLD_dom_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR041680 PH_8
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF15409 PH_8, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSH3_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38713
Secondary accession number(s): D3DL23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 31, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
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