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UniProtKB - P38709 (UGPA2_YEAST)
Protein
Probable UTP--glucose-1-phosphate uridylyltransferase
Gene
YHL012W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Plays a central role as a glucosyl donor in cellular metabolic pathways.
By similarityCatalytic activityi
- EC:2.7.7.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 181 | UTPBy similarity | 1 | |
Binding sitei | 211 | UTP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 242 | UTPBy similarity | 1 |
GO - Molecular functioni
- UTP:glucose-1-phosphate uridylyltransferase activity Source: GO_Central
GO - Biological processi
- glycogen metabolic process Source: GO_Central
- UDP-glucose metabolic process Source: GO_Central
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)Alternative name(s): UDP-glucose pyrophosphorylase Short name: UDPGP Short name: UGPase |
Gene namesi | Ordered Locus Names:YHL012W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001004, YHL012W |
VEuPathDBi | FungiDB:YHL012W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185766 | 1 – 493 | Probable UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST | 493 |
Proteomic databases
PaxDbi | P38709 |
PRIDEi | P38709 |
TopDownProteomicsi | P38709 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36411, 54 interactors |
IntActi | P38709, 1 interactor |
STRINGi | 4932.YHL012W |
Miscellaneous databases
RNActi | P38709, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 108 | UTP bindingBy similarity | 4 | |
Regioni | 107 – 108 | Substrate bindingBy similarity | 2 | |
Regioni | 240 – 242 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the UDPGP type 1 family.Curated
Phylogenomic databases
eggNOGi | KOG2638, Eukaryota |
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_0_0_1 |
InParanoidi | P38709 |
OMAi | NESASTC |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
PANTHERi | PTHR43511, PTHR43511, 1 hit |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P38709-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVFSGVNKI EFEGTFEGIG KDVVMSQMIR ALQKHFPSIR DKNYEFSLFL
60 70 80 90 100
HIFQRYVLEN TSITHDLVCD KIRLPIIDEV VELDDIKNYG LLEGKLLSKL
110 120 130 140 150
AILKLTGKAN PIIGKESPLF EVKNGMSSLD VIVRQTQNLN VRYNSDVPLI
160 170 180 190 200
FMTSLETESQ VSNFLEEHYS SSKVRWKTVV QSSFPQIDKD RLLPIDLQIN
210 220 230 240 250
SHENDFWYPC GTGNLTDTLY FSGELDKLIA QGKEILFVSN VDNLGATGDL
260 270 280 290 300
NILNFIINEK IEYLVEVVER TANVSNTGVL ATYKGKLRSV YYNCLSNESA
310 320 330 340 350
STCRIVNTNN IWIDLKKLKV LIESNSLNLP IHSSESKITH KNEEIECLQF
360 370 380 390 400
KTQLVDCIAF FPNSRVLKVS RDRFLPLRTC KDLFLLKSTL YDLDSNGTFN
410 420 430 440 450
LYPLKFGLLP SIDLGDEFAT YETFKIGVPD IPNILELEHL TVMGNVFFGR
460 470 480 490
NITLKGTVII ICDENDVITV PDGSILENVT IWHKSQLEDM NGY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11582 Genomic DNA Translation: AAB65065.1 BK006934 Genomic DNA Translation: DAA06674.1 |
PIRi | S46826 |
RefSeqi | NP_011851.1, NM_001179092.1 |
Genome annotation databases
EnsemblFungii | YHL012W_mRNA; YHL012W; YHL012W |
GeneIDi | 856374 |
KEGGi | sce:YHL012W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11582 Genomic DNA Translation: AAB65065.1 BK006934 Genomic DNA Translation: DAA06674.1 |
PIRi | S46826 |
RefSeqi | NP_011851.1, NM_001179092.1 |
3D structure databases
SMRi | P38709 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36411, 54 interactors |
IntActi | P38709, 1 interactor |
STRINGi | 4932.YHL012W |
Proteomic databases
PaxDbi | P38709 |
PRIDEi | P38709 |
TopDownProteomicsi | P38709 |
Genome annotation databases
EnsemblFungii | YHL012W_mRNA; YHL012W; YHL012W |
GeneIDi | 856374 |
KEGGi | sce:YHL012W |
Organism-specific databases
SGDi | S000001004, YHL012W |
VEuPathDBi | FungiDB:YHL012W |
Phylogenomic databases
eggNOGi | KOG2638, Eukaryota |
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_0_0_1 |
InParanoidi | P38709 |
OMAi | NESASTC |
Miscellaneous databases
PROi | PR:P38709 |
RNActi | P38709, protein |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
PANTHERi | PTHR43511, PTHR43511, 1 hit |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UGPA2_YEAST | |
Accessioni | P38709Primary (citable) accession number: P38709 Secondary accession number(s): D3DKQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | September 29, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families